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Thursday, 15 September 2016

Improvement in core ASD symptoms after long-term treatment with probiotics




Another brief post today to draw your attention to a paper highlighted on the Questioning Answers blog.

There are two virtually identically probiotics one called VSL#3 and the other called Viviomixx.  As pointed out in a recent post there is an ongoing clinical trial of Vivomixx.

  

Ongoing Clinical Trial of Vivomixx Probiotic in Children with Autism




Some readers of this blog are trialing VSL#3 or Viviomixx.

The new paper is a case study of a 12 year old boy with severe autism who was given VSL#3 at his residential care home.

He has celiac disease, but his doctors were surprised that when the reduction in severity of abdominal symptoms was accompanied by an improvement in his autism.

This should not come as a surprise to regular readers.  Just recall Kanner’s subject #1, Donald Triplett, who was later diagnosed with juvenile arthritis. When his arthritis was treated his autism improved.  This is exactly what should be expected.

Treat your comorbidities, particularly those of an inflammatory/auto immune nature, and very likely you will improve behavior and even cognition.





Abstract

Objectives: Autism spectrum disorder is a neurodevelopmental condition that typically displays socio-communicative impairment as well as restricted stereotyped interests and activities, in which gastrointestinal disturbances are commonly reported. We report the case of a boy with Autism Spectrum Disorder (ASD) diagnosis, severe cognitive disability and celiac disease in which an unexpected improvement of autistic core symptoms was observed after four months of probiotic treatment.
Method: The case study refers to a 12 years old boy with ASD and severe cognitive disability attending the Villa Santa Maria Institute in resident care since 2009. Diagnosis of ASDs according to DSM-V criteria was confirmed by ADOS-2 assessment (Autism Diagnostic Observation Schedule).
The medication used was VSL#3, a multi-strain mixture of ten probiotics. The treatment lasted 4 weeks followed by a four month follow-up.
The rehabilitation program and the diet was maintained stable in the treatment period and in the follow up. ADOS-2 was assessed six times: two times before starting treatment; two times during the treatment and two times after interruption of the treatment.
Results: The probiotic treatment reduced the severity of abdominal symptoms as expected but an improvement in Autistic core symptoms was unexpectedly clinically evident already after few weeks from probiotic treatment start. The score of Social Affect domain of ADOS improved changing from 20 to 18 after two month’s treatment with a further reduction of 1 point in the following two months. The level 17 of severity remained stable in the follow up period. It is well known that ADOS score does not fluctuate spontaneously along time in ASD and is absolutely stable.
Conclusions: The appropriate use of probiotics deserves further research, which hopefully will open new avenues in the fight against ASD.








2 comments:

  1. Peter, when my son was on Vivomixx, the effect we had was similar to taking Olanzapine, which is a dopamine antagonist.
    I wonder if dopamine is actually implicated here. Petra

    ReplyDelete
  2. An interesting article regarding GI and neurological conditions.

    "ENS structure and neurochemistry resemble that of the CNS, therefore pathogenic mechanisms that give rise to CNS disorders might also lead to ENS dysfunction, and nerves that interconnect the ENS and CNS can be conduits for disease spread. We review evidence for ENS dysfunction in the aetiopathogenesis of autism spectrum disorder, amyotrophic lateral sclerosis, transmissible spongiform encephalopathies, Parkinson disease and Alzheimer disease."

    http://www.nature.com/nrgastro/journal/v13/n9/full/nrgastro.2016.107.html

    A reasoning why things that alter GI function/resilience/immunity can be so positive or so disruptive, at least for some.

    ReplyDelete

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