tag:blogger.com,1999:blog-655962722302095847.post8730319056158603638..comments2024-03-28T22:33:35.806+01:00Comments on Epiphany: OAT3 inhibitors for Bumetanide - Probenecid, but also Aspirin, Chlorogenic acid (Coffee), Epicatechin (Cocoa, Cinnamon) and more.Peter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger78125tag:blogger.com,1999:blog-655962722302095847.post-22373316173478579372023-09-01T06:46:16.780+02:002023-09-01T06:46:16.780+02:00Aspirin is a sonic the hedge hog inhibitor. Intere...Aspirin is a sonic the hedge hog inhibitor. Interesting article on ibd and shh<br /><br />https://www.nature.com/articles/s41420-021-00679-7Unknownhttps://www.blogger.com/profile/04570315027088928366noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-64995955472390763312019-09-24T08:43:07.904+02:002019-09-24T08:43:07.904+02:00Evangelos, Clemastine for allergy is OTC (no presc...Evangelos, Clemastine for allergy is OTC (no prescription) in the UK. It is not usually stocked in high street pharmacies, but you can buy online from a legitimate UK pharmacy. The issue is whether they will post it to Greece and how much the shipping will cost. 60 tablets cost about Eur 11. You can always find a Greek friend in the UK to buy it and bring it, or mail it to you. Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-29755802022253814212019-09-23T14:12:43.857+02:002019-09-23T14:12:43.857+02:00Hello Evangelos, I have never ordered clemastine o...Hello Evangelos, I have never ordered clemastine online but my close friend with MS ordered from a UK online pharmacy less than a year ago. I remember her saying she paid something like 50-60 euros for two packets shipping included. The delivery takes a long time unless you pay extra for quick shipment.<br />Personally I ordered drugs online only once, supplements several times, I think it was from UK, and was completely satisfied with my order, also had to wait long though.<br />This information is through my personal experience, so please always check yourself if it is valid.<br />Nice talking to you Evangelos, wish you good luck.<br />Petrapetra petrahttps://www.blogger.com/profile/04739468164075216419noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-58909311271287785882019-09-22T18:38:22.481+02:002019-09-22T18:38:22.481+02:00Elena, I am glad you can buy Bumetanide in Athens....Elena, I am glad you can buy Bumetanide in Athens.<br /><br />Our reader in Thessaloniki could not buy it locally and so came up with the other solution. That was a few years ago. Things may well have changed. The Serbian Bumetanide is about 2 euros.<br /><br />There was also Thomas from somewhere in Greece who could not get Bumetanide and asked Petra for help.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-27638099405123079072019-09-22T04:42:38.923+02:002019-09-22T04:42:38.923+02:00I'd like to clear up the misconception that B...I'd like to clear up the misconception that Bumetanide is not available in Greece. Peter, I read a previous comment you wrote that one would have to get Bumetanide in Serbia as it is not sold in Greece. I've been giving it to my daughter for the past 4 years and buy it over the counter here in Athens without a prescription (the cost is around 11 euros per pack of 28 x 1mg tablets). Elenanoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-45631039345983643622019-09-21T18:20:13.318+02:002019-09-21T18:20:13.318+02:00Hello Petra, I am interested in importing Clemasti...Hello Petra, I am interested in importing Clemastine to Greece since it's not available here. Are you experienced in ordering pharmaceuticals online for personal use? Contact me over email if you can: sarantis.v@gmail.com <br />Thanks in advance.Evangeloshttps://www.blogger.com/profile/16843090058173003247noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-62357155489490602172019-09-21T18:17:21.866+02:002019-09-21T18:17:21.866+02:00Καλησπέρα Πέτρα, έχεις καταφέρει να εισάγεις στην ...Καλησπέρα Πέτρα, έχεις καταφέρει να εισάγεις στην Ελλάδα την κλεμαστίνη(clemastine)? Είχες αναφέρει ότι είχες εισάγει το Bumetanide από Σερβία σε ένα σχόλιο, αλλά το Bumetanide είναι εγγεγραμένο στον ΕΟΦ. Η Clemastine όχι. Θα ήθελα να μιλήσουμε σχετικά με τη δυνατότητα εισαγωγής φαρμάκων απο εξωτερικό καθώς ο ίδιος αντιμετωπίζω σοβαρή ΔΕΠΥ και οι συμβατικές αγωγές δεν με κάλυψαν. Αυτό είναι το email μου.<br />sarantis.v@gmail.com <br />ΕυχαριστώEvangeloshttps://www.blogger.com/profile/16843090058173003247noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-22854817293532779562017-11-13T23:55:46.130+01:002017-11-13T23:55:46.130+01:00Hi Nat,
Thanks for your view on it, Im not exactl...Hi Nat,<br /><br />Thanks for your view on it, Im not exactly sure what causes the unwanted effects in me, but bromelain is able to induce il-6.<br /><br />Another possibility for my response could be an allergic response to bromelain (this happens a fair bit apparantly).<br /><br />Im not exactly what a silent reflux is, I had just used google, but I doubt that was the problem.<br />Also I used to have very low stomach acid in the past, at some point I was taking 15 pills of betaine hcl (the 650mg ones per pill!!!) before each meal for the first 2 days, then gradually dropping them and eventually now I get a 'burning' feeling if I take 2-3 before a meal (I test this with my my half remaining bottle like once per 2 weeks, to get a rough indication what my hcl levels are like).<br />Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-16305387777425257802017-11-13T14:12:40.605+01:002017-11-13T14:12:40.605+01:00Aspie,
what you describe could easily be caused ...Aspie, <br /><br />what you describe could easily be caused by "silent reflux" (LPR), and bromelain is known to cause reflux in some people.<br /><br />Both stiff neck and headaches have been described as possible symptoms of reflux - both the classic heartburn type GERD and the 'silent' LPR reflux. <br /><br />Imo LPR could be a massive problem in autism in general, causing many periodic symptoms and behaviours. <br /><br />One thing it does not cause, most of the time, is heartburn (hence 'silent), so it is hard to pinpoint. <br /><br />Natnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-66037044107456217132017-11-13T10:48:20.286+01:002017-11-13T10:48:20.286+01:00Ive stopped the bromelain by the way, it kept givi...Ive stopped the bromelain by the way, it kept giving me headache like symptoms and a stiff neck/shoulders, felt very tense.<br /><br />Luckily the effect that bromelain had on me quickly vanished also.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-10771592229537468562017-11-13T10:46:33.094+01:002017-11-13T10:46:33.094+01:00Honestly they felt very easy on the stomach for me...Honestly they felt very easy on the stomach for me, you got to give them AFTER meals by the way unlike most other probiotics which are best absorbed on a somewhat empty stomach like 30mins before a meal.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-61740874657513695122017-11-13T00:45:11.587+01:002017-11-13T00:45:11.587+01:00Hi I also received clostridicum butyricum fro Japa...Hi I also received clostridicum butyricum fro Japan awhile back, but was a bit concerned giving the tablets to my child as they contain talc. Am I just being paranoid? Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-10955694423929737872017-11-11T11:59:41.378+01:002017-11-11T11:59:41.378+01:00Took 2 tablets of bromelain again yesterday, one w...Took 2 tablets of bromelain again yesterday, one with breakfast the the other one 30minutes before dinner, no bad negative effects yet.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-16088905932843601352017-11-10T09:44:19.429+01:002017-11-10T09:44:19.429+01:00Forgot to add this Ling, yes I do believe my immun...Forgot to add this Ling, yes I do believe my immunesystem is overactive.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-24817814932662186652017-11-10T09:43:42.635+01:002017-11-10T09:43:42.635+01:00Something very interesting I have just found regar...Something very interesting I have just found regarding interleukin-6, as I allready knew, balance is the key and people still do need il-6:<br /><br />Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep.<br />https://www.ncbi.nlm.nih.gov/pubmed/19546306<br /><br />"To test this hypothesis, we compared effects of intranasally administered IL-6 (I guess they took it intranasally because it gets into the brain easily then???) (vs. placebo) on sleep-dependent consolidation of declarative (neutral and emotional texts, 2-dimensional object location) and procedural (finger sequence tapping) memories in 17 healthy young men. IL-6 DISTINCTLY IMPROVED THE SLEEP-RELATED CONSOLIDATION OF EMOTIONAL TEXT MATERIAL (P<0.03), which benefits mostly from sleep in the second night-half, in which rapid eye movement sleep (REM) dominates the non-REM-REM sleep cycle. During this second night-half, the amount of electroencephalogram slow-wave activity (0.5-4 Hz) distinctly increased after IL-6 (P<0.01). Other types of memory were not affected. The ability of IL-6 to ENHANCE SLEEP-ASSOCIATED EMOTIONAL MEMORY CONSOLIDATION highlights an example of a functional interaction between the central nervous and immune system."Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-48810750923708599162017-11-10T09:33:03.768+01:002017-11-10T09:33:03.768+01:00Hi Ling,
I stopped it after about 3 weeks or so (...Hi Ling,<br /><br />I stopped it after about 3 weeks or so (keep in mind this was around 4 years ago), it made me horribly depressed, gave me general weakness, increased obsessions, anxiety, was scared to go out on the street and had the same pressure around my ears/sinusses build up just like I was having bromelain 2 days ago.<br /><br />I was taking olife leaf extract to try and help bring my thyroid levels up (t4 was in the medium range then, but t3 was kind of low and olive leaf can help do this conversion) aswell as for the blood pressure lowering effects (which taurine and NO-boosters seem to take great care off - im actually normotensive now and I used to be pre-hypertension for nearly a decade!).<br /><br />Back to bromelain: So I took 1000GDU twice daily BETWEEN MEALS (so 2000GDU total) and that gave me the same earpressure/earpain/nasal /sinus problems as olive leaf extract also started with.<br /><br />Today Ive decided to give it another go and this time WITH MEALS!, I can actually hear? my stomach working now when I took it with food and no earpain coming up yet or so but ill update it by the end of the day.<br /><br />Found this by the way:<br /><br />Dose-dependent induction of IL-6 by plant-derived proteases in vitro<br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809566/ <br /><br />"The production of IFNγ and IL-10 was not altered by bromelain or papain, indicating a selective and differential immune activation. Both proteases impaired cytokine stability, cell proliferation and expression of cell surface molecules like CD14 only marginally, suggesting no impact of these mechanisms on protease-mediated cytokine release. These findings might provide the mechanistic rationale for the current use of proteases in wound healing and tissue regeneration since these processes depend on IL-6 induction."<br /><br />Seems bromelain works by enhancing il-6, now as we all know il-6 is often high in autism and myself included I believe, so this is a bit trial and error for me aswell hence being very carefull with it, I want to see how body responds to it.<br /><br />As I stated in my post 2 days ago I did noticed I felt somewhat 'different' thought not in a bad way the day I took bromelain between meals.<br /><br />It could have been that I was experiencing increased PGE2, induced by il-6.<br /><br />Seems I was right about bromelain affecting sinusses:<br /><br />https://examine.com/supplements/bromelain/<br />"Bromelain may reduce complications with acute sinusitis known as a 'stuffed nose' to a greater extent than placebo.[54][55][56] One study conducted noted that 83% of persons using bromelain had reductions in nasal inflammation as compared to 52% of the placebo.[57] Bromelain appears to reduce the length it takes to alleviate sinusitis significantly, yet combining bromelain with traditional therapy for sinusitis appears to reduce the efficacy of both."Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-36929078290925605852017-11-09T21:51:05.822+01:002017-11-09T21:51:05.822+01:00Hi Aspie!
Did you stop the olive leaf extract beca...Hi Aspie!<br />Did you stop the olive leaf extract because of your reaction, or did you push through (if that is possible) Could it have been an effect of low blood pressure instead of herxheimer? <br />Is you immune system generally on overdrive or the other way around?<br />I would appreciate some advice since I am planning an olive leaf extract trial soon.<br /><br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-42278467249365780752017-11-09T17:09:37.311+01:002017-11-09T17:09:37.311+01:00No problem AJ,
I have stopped the bromelain today...No problem AJ,<br /><br />I have stopped the bromelain today and the symptoms I had yesterday are decreasing (still taking the digest gold and digest spectrum and eating bread!).<br /><br />Coconutoil i tollerate very well, never any stomach discomfort from that, only positives from that, aswell as olive oil and goat cheese (high butyric acid fat source).Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-70589963693289640002017-11-09T14:40:12.592+01:002017-11-09T14:40:12.592+01:00Try it and let us knowTry it and let us knowAspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-9892181036843544962017-11-09T14:07:07.040+01:002017-11-09T14:07:07.040+01:00Hi Aspie,
Good news on starting your digestive en...Hi Aspie,<br /><br />Good news on starting your digestive enzymes.<br /><br />Yes, keep me posted on any interesting findings.<br /><br />It's interesting you mention the die-off reaction, as that is something I am definitely going to keep my eyes on. <br /><br />By the way, I read that Coconut Oil may be helpful with Candida so I have ordered some. <br /><br />I'll keep you (and the board) posted on my efforts with prescription and non-prescription methods to beat the candida and clostridia, but check out coconut oil as that seems to have many benefits.<br /><br />Have a great day Aspie!<br /><br />AJ Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-37089594378341373242017-11-09T11:35:17.285+01:002017-11-09T11:35:17.285+01:00Well in that case you could start with 0.5mg and t...Well in that case you could start with 0.5mg and test from there and see if the OAT3 inhibitors will yield the same kind of results you get from a 1mg dose. This is trivializing things obviously, but it is a start.Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-31961703230224947082017-11-09T11:32:05.711+01:002017-11-09T11:32:05.711+01:00Well other than the Simons Foundation which mostly...Well other than the Simons Foundation which mostly focuses on genetics studies (which is important), I would not expect much to get done from the formal research side into autism going forward as science is all screwed up politically right now here in the United States and organizations like Autism Speaks have lost a lot of support compared to just 5 years ago both because of missteps by the organization, as well as the myriad of autism organizations that seem more concerned with playing politics with each other, rather than getting along and investing their scarce resources wisely. Autism Speaks is also more focused on helping people with autism with practical solutions and not so much the hard science anymore if you follow their new mission statement.<br /><br />Really, you get the feeling a lot of people in the autism research space are giving up due to lack of funding and obviously if you read Peter's blog, you realize there is indeed a lot of autism related research going on in the world, just it is not directly autism related much of the time as it covers the more politically relevant and better funded research for neurodegenerative diseases like Alzheimer's disease that have people who are directly affected and vote for what is most relevant to them. Most people with autism cannot advocate for themselves and therefore funding for autism research will always play second fiddle to just about everything else, aside from the temporary bump in funding when autism rates seemed like they were on a never ending increase (the famed 1 out of 68 number).<br /><br />Also with respect to the political issues, here in the states you have a situation where universities have expunged pretty much all people who believe in religion or else have conservative values and as a result they find themselves surprised when half the country or more won't support research funding in general under the premise you should not fund your opposition. It also does not help that other than wealthy families, college education is becoming more a luxury good that signals family status that much of the rest of society is beginning to resent. Why would you support institutions, including research institutions, your children or grandchildren are more or less locked out of.<br /><br />The other problem of course is like most European governments, the United States has massive debt and demographic challenges that were addressed in the short-term via immigration (both legal and illegal), but in the long run the chickens are coming home to roost as older generations keep stealing from the younger generations via the welfare state, and that includes austerity towards research which generally benefits society in the future and not the present. Younger people cannot afford to get married and raise children, which only exacerbates the problem as the birth rate continues to crater. You can't have increasing research budgets with a shrinking economy due to a shrinking population so I am a little pessimistic on this front.<br /><br />In the meantime, we have to throw enough stuff at the wall to see if it sticks and pay close attention to the research that still is getting funded and go from there. Obviously there are better more formal ways for this to be achieved, but there are too many artificial factors holding things back in the formal research space to just twiddle our thumbs as parents and hope somebody else solves the problems our children face on a daily basis.Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-64451466583732640102017-11-09T00:24:20.533+01:002017-11-09T00:24:20.533+01:00Has anybody tried injections of Cerebrolysin?Has anybody tried injections of Cerebrolysin?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-40285615201691990152017-11-08T21:23:05.244+01:002017-11-08T21:23:05.244+01:00Seems this is the reason I had the response I desc...Seems this is the reason I had the response I described from bromelain:<br /><br />https://jonbarron.org/article/proteolytic-enzyme-formula<br /><br />Theres a huge difference between taking bromelain with food vs in between meals!<br />For those interested in this it is a good video and shows how important it is to decide to take it with or without food.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-18775872536170887732017-11-08T21:05:10.839+01:002017-11-08T21:05:10.839+01:00Hi AJ,
Yesterday my 3 digestive enzyme supplement...Hi AJ,<br /><br />Yesterday my 3 digestive enzyme supplements arrived:<br /><br />Enzymedica Digest gold with ATPro<br />Enzymedice Digest spectrum (the one with DPP-IV)<br />Source Naturals Bromelain 2000gdu/gram<br /><br />Now I took 1 digest gold and 2 digest spectrum with breakfast and I noticed that after finishing my breakfast I did not have the typical 'food/insulin crash' that I normally somewhat get after eating (keep in mind the crash I describe has allready improved 80% or so throughout the last 2 years).<br /><br />Now, about 2 hours later I decided to take the bromelain (500mg = 1000GDU without food yes, but this is also a way to take it according to the internet and on the label), I noticed a somewhat odd feeling in my head about 10minutes after taking it and about 30mins later I definatly felt somewhat different (not necesarry in a bad way though, hard to put into words).<br />I also noticed WAY more mucous and the urge to scratch my legs a dozen of times (which I normally rarely do).<br /><br />Now the odd feeling in my head I never thought about after it passed and I carried on with my day.<br /><br />Lunch:<br />Again 1 digest gold and 2 digest spectrum, again no stomach discomfort at all afterwards (I was eating bread for that matter which I normally rarely do as a way to test it).<br /><br />Then at around 5pm I took another bromelain 500mg=1000GDU and a few minutes later I again get this weird feeling in my head and mild ear pressure.<br /><br />Now at 8pm ish my time I keep getting pressure around my ears and my ears are starting to hurt a little (not awefull much).<br /><br />It seems to me that it is most likely the bromelain giving me the herxheimer reaction (I had the same with olive leaf extract and I didnt made the connection at the start and ended up getting incredibly depressed weak and a strong aversion for every type of food).<br /><br />So tomorrow Im dropping out the bromelain as Im pretty sure this is giving me a die-off reaction (not sure if continueing could actually be benefical though?).<br />Either way I cant really afford to get sick with my job and all...<br /><br />I found this by the way:<br /><br />Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain.<br />https://www.ncbi.nlm.nih.gov/pubmed/22517542<br /><br />Seems to effect the circadian immune system function? not sure what to exactly make of that but it seems like it can powerfully modulate it.<br /><br />https://selfhacked.com/blog/bromelain-benefits/<br /><br />Also it seems to be possible to be allergic to bromelain according to many websites resulting in symptoms such as headache, fever, itching, nausea, etcAspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.com