tag:blogger.com,1999:blog-655962722302095847.post8658865743680028827..comments2024-03-28T22:33:35.806+01:00Comments on Epiphany: The Clever Ketogenic Diet for some AutismPeter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger64125tag:blogger.com,1999:blog-655962722302095847.post-85837142144379718992018-07-11T08:51:41.924+02:002018-07-11T08:51:41.924+02:00Tyler, thank you for explaining.
It seems I'v...Tyler, thank you for explaining.<br /><br />It seems I've got similar issues with 750 mg. <br /><br />Why would lower dose induce such behaviours not seen with higher dose? Agnieszka Wroczyńskahttps://www.blogger.com/profile/04738535364585304041noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-9032232372931343532018-07-10T08:20:45.371+02:002018-07-10T08:20:45.371+02:00First off, I give agmatine mixed with milk and suc...First off, I give agmatine mixed with milk and sucralose (to deal with the taste) since my son will not do pills. The amount I give is one teaspoon which is roughly 2g per day. The proteins in the milk may decrease the absorbability of the agmatine, but that has been what has worked best. I recently tried going to the 1g dose as that is closer to what Peter does and had some issues with that. Also, he does not always consistently finish all of his beverage at once, so there are a lot of variables here.<br /><br />Secondly, when I first started giving Agmatine at a dose closer to what Peter gave, I would get a lot more speech and other good effects out of my son, but he would also sometimes go into violent rages so I stopped using it. I then looked at another study involving rats and determined that the allometric scaling suggested I was giving too little so I tried it again at the larger dose and didn't have any of the big side effects, just better attentiveness throughout the day.<br /><br />As for your last question, I don't think there is any issue with keto and interactions with agmatine. It has neurological effects lasting up to 12 hours, but the peripheral effects have a very short half-life in the body, of which the a2a adrenoreceptor is the most significant.Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-1944749477059230992018-07-09T08:51:35.098+02:002018-07-09T08:51:35.098+02:00Tyler, you wrote here a while ago that agmatine ca...Tyler, you wrote here a while ago that agmatine can have horrible effects - can you elaborate? Is your son still on 1.2 g daily?<br /><br />Are there reports on agmatine in the humans other than the 5 years case report you highlighted? I couldn't find any and rats don't usually report headache for example.<br /><br />My son has been on beta hydroxybutyrate salts for a few months and also I wonder if there can be any potential for interaction with agmatine e.g. hypoglycemic.Agnieszka Wroczyńskahttps://www.blogger.com/profile/04738535364585304041noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-39460341938024019262017-01-28T17:40:28.345+01:002017-01-28T17:40:28.345+01:00Hi Agneiszka,
Thank you so much for that informa...Hi Agneiszka, <br /><br />Thank you so much for that information. Last time I had trial led NAC, bumetanide and l.reuteri in quick succession probably with some overlap too so attributing effects to specific interventions became a little complex. If and when I retry I will be more careful. <br /><br />RegardsKritikanoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-87196232042571703462017-01-28T12:44:14.946+01:002017-01-28T12:44:14.946+01:00Christine,
What a relief it must be to find somet...Christine,<br /><br />What a relief it must be to find something which helps your son. I had read about inositol..such a simple intervention. About the dysfluency aspect, in fact even I am.not sure if sppech problems increased with bumetanide..its only that he was suddenly pronouncing words with such clarity around thst period that the loss became more accentuated. I wish we could put in a microchip inside our kids bodies which would record all biochemical fluctuations..this seems to be the only way we can ever say with decent certainty what is causing what. <br /><br />What you found out about the nac is interesting. In fact, I felt that in my son, keeping the discommfort caused by the high dose aside, nac even brought about improvement in cognition. I think low dosing of drugs/supplements especially the ones which can cause uncomfortable physical experience is what will work best for my son. I absolutely have to try nac again but follow my own gut instincts when it comes to my sonds gut health. <br /><br />Warm wishes <br /><br />Kritikanoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-28442700180677252042017-01-28T12:23:01.912+01:002017-01-28T12:23:01.912+01:00Kritika,
Just to make it clear: my son used bumet...Kritika,<br /><br />Just to make it clear: my son used bumetanide for 1,5 year without any speech issues. So it is possible that there is something different going on in your son and mine. <br /><br />I didn't use memantine or similar drugs. There was memantine trial where I live few years ago. It was a part of a big, international study, which finally failed. Anyway I was told that all parents in my city decided to continue memantine after the trial ended.<br /><br />Here is a paper on memantine induced speech issues:<br />https://www.ncbi.nlm.nih.gov/pubmed/23819879<br />In both kids it was reversible and in one of them "the speech difficulty<br />was completely relieved despite continuation of memantine."<br /><br />It is not about anitbiotic in my son as he did not use antibiotic then. It was viral, flu-like illness. <br /><br />Low dose clonazepam is a good idea. It is one of few treatments that clearly improved expressive speech in my son. Unfortunately whenever I use acetazolamide it seems like it increases clonazepam blood level and it works only in narrow therapeutic window in my son. Agnieszka Wroczyńskahttps://www.blogger.com/profile/04738535364585304041noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-21078502393156211912017-01-28T11:58:01.652+01:002017-01-28T11:58:01.652+01:00SB,
In my son mast cell disorder was suggested by...SB,<br /><br />In my son mast cell disorder was suggested by a clever immunologist although his symptoms were far from typical (crying spells every full moon). So I used mast cell stabilizers (cromoglicate and antihistamines) and then tried verapamil according to Peter's blog, which effect was profound. <br /><br />But it is just one example and I think there can be many reasons for inflammation in a child with autism.<br /><br />Some people use anti-inflammatory drugs eg. ibuprofen and others were found helpful in some studies:<br />https://www.ncbi.nlm.nih.gov/pubmed/22782459 <br />My son does not tolerate ibuprofen.<br /><br />In Peter's PolyPill atorvastatin has anti-inflammatory properties.<br />Agnieszka Wroczyńskahttps://www.blogger.com/profile/04738535364585304041noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-66007603879505744702017-01-28T00:26:27.789+01:002017-01-28T00:26:27.789+01:00Kritika,
I just saw your post and yes, my son did ...Kritika,<br />I just saw your post and yes, my son did have increased dysfluency while trialing Bumetanide. It is difficult to say if that was the cause because he has had this issue at various times in his life, but it absolutely increased during the trial. I took some time off after Bumetanide and a trial of Monteleukast as well as Zoloft (not at the same time). After he was cleared out of all drugs/supplements for a couple of weeks, I decided to try the supplement Inositol. Anxiety is a big problem for him and I had read about the relief some people get while taking it. It is helping a lot. I am happy to share with anyone who is interested. The OCD was still a big problem so I went back to the pharmaNAC (I had about 6 or 7 tabs left). Things got even better with NAC. Much less dysfluency and less repeating and scripting. Two days ago I ran out of NAC and quickly ordered more. Since he was only taking Inositol I decided to add in the Enduracell broccoli sprouts. Day 1 -- FANTASTIC -- school said he was able to work for 1/2 hour straight without a break! Day 2 (TODAY)-- Bad dysfluency and very panicky. So, I can say this: NAC helps my son with dysfluency and repetitiveness.<br />Christine Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-54339966205118601572017-01-27T12:32:47.506+01:002017-01-27T12:32:47.506+01:00MH, I doubt it.MH, I doubt it.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-41129411703816369852017-01-27T12:11:19.820+01:002017-01-27T12:11:19.820+01:00A snapshot of the effect of all the medicines and ...A snapshot of the effect of all the medicines and supplements she takes was at the Mayo clinic at the beginning of the month. The first week that we were there, we had to spend almost entire days at the clinic as they would set us up with several appointments with the doctors, each lasting over an hour, and also many lab visits, imaging etc. She was completely calm, and managed brilliantly, including having her blood drawn several times. The most impressive was the MRI with contrast dye that was 45 minutes long and which she did perfectly without sedation. RGhttps://www.blogger.com/profile/07458829468580940361noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-14075645951803173002017-01-27T12:00:15.399+01:002017-01-27T12:00:15.399+01:00Peter, Agnieszka,
Not having the clonazepam, has...Peter, Agnieszka, <br /><br />Not having the clonazepam, has very clear and direct effects. Last week, during singing lessons her voice began sinking, and except for the songs that she was proficient at, her voice wouldn't rise up, and there was no initiative from her to keep up with the accompanying piano. Before we started the clonazepam, she used to be almost completely inaudible in class, and nothing could make her raise her voice. Last year, the singing group she belongs to had two performances, one on May 1st, and the second on June 4th. Both were in front of huge audiences. At the May program, she was nearly silent, couldn't even be heard by people next to her, and became very anxious on stage and had a meltdown and we had to usher her off quickly. Sometime in May we started the clonazepam, and at the June 4th program, she stunned us all by leading the group and singing to great applause. Confident on stage, without any anxiety or fear. Nowadays, we have the opposite problem, with her getting into rows with the other kids because she refuses to give them their turn at leading and insists on singing over everybody else. RGhttps://www.blogger.com/profile/07458829468580940361noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-82654620403167451262017-01-27T11:37:15.808+01:002017-01-27T11:37:15.808+01:00Hi Agnieszka,
I have something interesting to re...Hi Agnieszka, <br /><br />I have something interesting to report here. Over the last month, with all that was going on, my daughter's dosing of sytrinol and verapamil had become irregular. I thought it wouldn't matter too much since we were stuck in deep winter. This last week, she started having slight reddening of her eyes and bouts of irritability and a little bit of SIB. I put her back on the regular dose of sytrinol and verapamil, but things hadn't stabilized after a couple of days. At that point, I looked at the bottle of clonazepam and realized that the compounding pharmacy had made a mistake and that it had expired in December. I think it was effective for a month longer and then went dead. I am only going to have the replacement tomorrow. In the middle of all this, the neurologist admitted her urgently three days ago for a 24 hour EEG and we will be discharged tomorrow. Since the EEG was completely normal after the first night, they stopped the Diamox to see if they could catch abnormal activity. Also, with all the diarrhea and lack of appetite etc, she had fallen out of ketosis. Two days ago, as far as I could tell things were deteriorating rapidly. Then, something interesting happened. My daughter's Bumetanide prescription is written for 1mg twice a day, though we have only been on 1mg once a day. The hospital adhered to the prescription and she got an additional 1mg in the evening. The poor behaviors stopped completely. Her calmness came back, with more speech. She began thanking the nurses appropriately, talking a bit to the doctors, and told the EEG technician that she was going to 'throw the EEG leads in the bin and go home on Friday'. We were doing reading classes and she has been doing very well. <br /><br />Her writing is not as good as it was, and today, strangely, after writing a couple of lines, suddenly she could not write an m. She kept saying and trying, but couldn't. She just kept scratching up and down with the pencil. It was as if her brain froze. It was unnerving, and I though it might be a seizure, but it wasn't. I have never seen this before. I wonder if the clonazepam and Diamox will override this if I keep the extra bumetanide dose. I will report back on this after a week of trialling. RGhttps://www.blogger.com/profile/07458829468580940361noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-80357503057250762542017-01-27T07:57:15.001+01:002017-01-27T07:57:15.001+01:00Sorry..my son just pressed the publish button on m...Sorry..my son just pressed the publish button on my phone. I just wanted to ask you if ensuring adequate levels of magnesium, calcium, sugar apart from potassium and lowering the dose be a good retesting strategy. I am trying to be objective here but as Peter had mentioned I feel slowly some of the good developments with bumetanide...specifically perseverance and interst which is so much linked to good learning ability has faded over time after stopping the bumetanide. The handwriting has also showed a deterioration..unfortunately we sometimes notice subtle gains only after we miss them following suspension of a therapy.<br /><br />OR do you think a clonazepam trial would be safer? In your sons case, do you have any earlier experience with a nmdar antagonist or agonist? Or could your son have reacted to the a antibiotic and diuretic combination? Diuretics can in combination with certain antibiotics cause ototoxicity and speech problems..I think I had read that somewhere when I was trying to ascertain the loss of sound clarity in my son.<br /><br />Regards Kritikanoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-29817692671644599252017-01-27T07:41:33.304+01:002017-01-27T07:41:33.304+01:00Agneiszka,
I read the abstract which you so kindl...Agneiszka,<br /><br />I read the abstract which you so kindly forwarded about certain chloride transport blockers action as non competitive nmdar antagonist. More importantly this seemed to be dose dependant..<br />This makes bumetanide a drug with wider neurological impacts. I do not have any idea if my son wil do better with an nmdar agonist or antagonist. I have read of severe reactions of certain kids to memantine and know of a kid who was danaged irreversibly following a drug/gfcf protocol designed by a respectable doctor. <br /><br />But without going into a panicky mode, I think a short, extremely well monitored retrial of bumetanide should not be too risky an endeavour. I feel pu Anonymoushttps://www.blogger.com/profile/03480846227414561711noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-57892764140480156422017-01-26T22:48:15.793+01:002017-01-26T22:48:15.793+01:00Thank you Agneiszka. You have done me a big favour...Thank you Agneiszka. You have done me a big favour by putting things in perspective which I think I was losing. I feel I should keep a record of things..how drug responses turn out over time because I tend to lose critical data and end up with a looose description which might not be as helpful.<br /><br />Before bumetanide, my son had started developing lot of clarity in his sounds...ma..n, ba..t, ba..d. Slowly he started losing the clarity and then he started muttering as if too bored or tired to speak. What concerns me, after you raised the point, is that even now he has not regained back that clarity and strength of sound I feel...on some days he is better. I do not understand. On one hand his writing strokes had become so good, even his therapist had commented on his better learning and more importantly, interest in learning.<br /><br />Could this be something else...if I remember right Christine's son and another persons daughter had issues with speech dysfluency coinciding with bumetanide use. In the light of this knowledge, its best to postpone another trial. <br /><br />I feel right now its best to focus on GI issues, inflammations and/allergies. Brain function is so fragile it becomes real daredevilry to try and rectify the problem..like a layperson trying to defuse a bomb following a manual written in a foriegn language and to add to the woes, this is a bomb different from.the one this manual describes.<br /><br /><br />Agneiszka, thanks for that very objective assessment of things. You probably just saved us from more trouble.<br /><br /><br /> Kritikanoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-7226580749704183362017-01-26T21:53:34.637+01:002017-01-26T21:53:34.637+01:00Peter, this is very interesting.
In a child with ...Peter, this is very interesting.<br /><br />In a child with mast cell activation inflammatory mediators may be abnormally released year-round in reaction to several triggers.<br /><br />"These data demonstrate that the inflammatory mediators induce the phosphorylation of NKCC1 in DRG neurons and suggest that this phosphorylation causes the early (< 3 hr) phase of enhanced Cl- accumulation" - do you think that this can be targeted in some way?<br />Agnieszka Wroczyńskahttps://www.blogger.com/profile/04738535364585304041noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-58604681043532834142017-01-26T20:32:28.361+01:002017-01-26T20:32:28.361+01:00Hi Kritika,
When my son was younger bumetanide &...Hi Kritika, <br /><br />When my son was younger bumetanide > 0.5 mg twice was associated with lots of urination, immediate fatigue and dark circles under his eyes, so I considered it all symptoms of dehydration. Or low blood pressure, shame on me, when my kids destroyed pediatric blood pressure meter at home I didn't buy new one. All was not severe and resolved quickly. <br /><br />So this was something different than you described.<br /><br />I would think that hyperfocusing on internal sensations could be manageable for example with explaining the situation (urination) in advance with pictures etc - at least in some children. Actually I think that everyone to be put on bumetanide should have it explained by means of communication best suitable for particular child.<br /><br />Speech loss is worrying. Can you describe more how it looked? Was it gradual or acute? Did it fully resolve? I am asking as my son has been experiencing speech disfluency for a year. The only medication that was new when it appeared was acetazolamide/Diamox, but all deteriorated rapidly after febrile infection together with stressful event at school afterwards. Unfortunately I am not able to explain it and help him.<br /><br />Diamox and bumetanide share some mechanisms. I haven't heard about speech issues as bumetanide side effect from the French doctor I asked. Also I asked some neurologists here about Diamox, none saw such problems. <br /><br />On the other hand there are case reports of reversible speech regression on memantine (NMDAR blocker) in ASD kids. Bumetanide was found to act as NMDAR antagonist as well:<br />https://www.ncbi.nlm.nih.gov/pubmed/1371581<br /><br />I don't know if this is relevant and would appreciate if someone here can help to explain your or my son's speech issues. <br /><br />This is not related to epileptiform discharges, his EEG is best ever now and clear from sleep spikes.<br /><br />Perhaps I would try lower dose with caution and withdraw immediately if you see any speech deterioration, provided it resolved fully before. <br /><br />Wish you good luck if you retry.<br /><br /><br /><br /><br /><br />Agnieszka Wroczyńskahttps://www.blogger.com/profile/04738535364585304041noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-20114236360790019212017-01-26T19:08:05.029+01:002017-01-26T19:08:05.029+01:00Agnieszka,Peter,
How do I find if my son has ...Agnieszka,Peter,<br /><br /> How do I find if my son has inflammation?Which medicines would work for inflammation?<br /><br />Thanks<br />SBUnknownhttps://www.blogger.com/profile/03620220473813800175noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-10202963283143350632017-01-26T18:18:05.977+01:002017-01-26T18:18:05.977+01:00Hi Agneiszka,
Greetings!
I just read one of you...Hi Agneiszka,<br /><br />Greetings! <br /><br />I just read one of your comments which I feel is significant with regards to my sons odd bumetanide experience.<br /><br />Looking back, my husband and I feel that bumetanide as well as nac, had given a smart edge to my son. His body movements had become more neurotypical...which could not have been a placebo affect. His gait, posture apart from the focus and learning. Agneiszkaa, following every effective intervention, improvement is first most perceptib le in his movements which sort of leaves lesser room for subjectivity. For instance, biogaia gastrus has given him a jump in coordination and imitation..this was visible within twenty four hours of the first dose which is half a tablet..he started imitating dance movements on tv and is getting better everyday. He displayed minor, momentary mean behaviour which I feel is also getting better. Bumetanide had led to improved academic performance too but the most disturbing side effect (there were others too) which I could not dismiss was his slow but steady loss of speech..it was as if his oral motor skills had declined due to fatigue. Also, he was hyperfocussing on something going on inside his body within 15 min of taking the drug, probably the physical discomfort of diuresis in a sensitive child. Potassium supplementation did not help..rather made things worse by causing stomach discomfort.<br /><br />Now, I think you mentioned somewhere that before your son turned 7, he could not tolerate 1mg of bumetanide and you were giving him 0.5 mg twice a day. It would be really helpful if you could recall what behaviours, symptoms made you decide that the dose is too high for him.<br /><br />I was keen to retrial bumetanide and wondering if halving the dose would be helpful. Your observation and balanced views regarding tolerance issues with bumetanide dose will really be valuable in helping me decide. You can understand..my son is behaviorally not really problematic and is becoming compliant and receptive. He is not even too hyperactive anymore now. So I do not want to do anything to jeopardize whatever natural progress he is showing.<br /><br />Best wishesKritikanoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-52309951331120986242017-01-26T17:34:03.351+01:002017-01-26T17:34:03.351+01:00Peter, for some of the RORa -- would good old Vit ...Peter, for some of the RORa -- would good old Vit A help. Or a certain form of Vit A? Thanks, MHAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-85356663303597668992017-01-26T17:00:31.715+01:002017-01-26T17:00:31.715+01:00Agnieszka, it appears that inflammation affects th...Agnieszka, it appears that inflammation affects the expression of KCC2 and NKCC1. This is documented in studies, but I also found this paper:-<br /><br />Modulation of chloride homeostasis by inflammatory mediators in dorsal root ganglion neurons<br /><br />https://molecularpain.biomedcentral.com/articles/10.1186/1744-8069-4-32<br /><br />“Conclusion<br />Our findings indicate that inflammatory mediators impact on Cl- homeostasis in DRG neurons. Inflammatory mediators raise intracellular Cl- levels”<br /><br />I found that bumetanide, but also NAC, appeared to "stop working" in the allergy season. Others also found this. Even a second daily dose of bumetanide in summer does not fully reverse this loss. I hope that the additional effect of KBr will help.<br /><br />If my son has trialed bumetanide in summer, I would have rejected it as an intervention.<br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-19264648863890251852017-01-26T16:35:36.846+01:002017-01-26T16:35:36.846+01:00SB, Peter,
Can inflammatory/allergic comorbiditie...SB, Peter,<br /><br />Can inflammatory/allergic comorbidities decrease bumetanide effect? According to the French studies, high-functioning children were the best responders and I wonder why. Peter, I think I recall one of your blog posts about the need to increase bumetanide dose during pollen season. I can't find it now, do I remember it right?<br /><br />I think (but I cannot prove it) that if my son with severe autism wasn't on verapamil and other mast cell stabilizers earlier, then I might not see good cognitive and social effects of bumetanide among all his mast cell driven behaviors he used to have before. <br /><br />So maybe in severe autism and little or no improvement on bumetanide, it would be worth checking if there are any treatable chronic inflammatory or allergic issues? Considering that they may present atypically and some trial and error way of treatment could be needed?<br />Agnieszka Wroczyńskahttps://www.blogger.com/profile/04738535364585304041noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-59963042654526429362017-01-24T20:14:26.572+01:002017-01-24T20:14:26.572+01:00Hi Kritika, sorry I wasn't clear - at the time...Hi Kritika, sorry I wasn't clear - at the time, I didn't use molybdenum for the sulfur tolerance - was just mentioning I have read that it is supposed to help . When my son was that young and reacting we just avoided sulfur compounds and worked on other things, esp. gut issues and inflammation. I have not tried carnosine in earnest. What are your son's biggest issues health wise? Allergies? Gut? you mentioned the cytoflora side effects: maybe he is sensitive to the sugar alcohols in the product? I have read molybdenum helps with detoxing effects from alcohol toxins - along with pantethine. You are kind and gracious Kritika ! I wish I was brilliant with all of this stuff. All I have is trial and error and learning from why things go wrong . :) I agree with not getting too carried away and throwing too much too soon. Had to learn that the hard way. <br /> Here is some info from Linus Pauling site about molybdenum as co factor functioning:<br /><br />Molybdenum is known to function as a cofactor for four enzymes<br /><br />Sulfite oxidase catalyzes the transformation of sulfite to sulfate, a reaction that is necessary for the metabolism of sulfur-containing amino acids (methionine and cysteine).<br />Xanthine oxidase catalyzes the breakdown of nucleotides (precursors to DNA and RNA) to form uric acid, which contributes to the plasma antioxidant capacity of the blood.<br />Aldehyde oxidase and xanthine oxidase catalyze hydroxylation reactions that involve a number of different molecules with similar chemical structures. Xanthine oxidase and aldehyde oxidase also play a role in the metabolism of drugs and toxins.<br />Mitochondrial amidoxime reducing component (mARC) was described only recently (4), and its precise function is under investigation. Initial studies showed that mARC forms a three-component enzyme system with cytochrome b5 and NADH cytochrome b5 reductase that catalyzes the detoxification of mutagenic N-hydroxylated bases.Tanyahttps://www.blogger.com/profile/01489962611979985947noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-50563809001230716882017-01-24T17:25:07.902+01:002017-01-24T17:25:07.902+01:00Peter,
In India it is...seek and you shall find.Peter,<br /><br />In India it is...seek and you shall find.Kritikanoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-82536463354530064502017-01-24T16:45:04.176+01:002017-01-24T16:45:04.176+01:00Kritika, yes I missed out the "c", I am ...Kritika, yes I missed out the "c", I am using 25 micro grams, so 25 mcg which equals 0.025 milligrams (mg). So your 0.25mg tablet would be enough for 10 days at my dosage. I am surprised you could buy such a small tablet.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.com