tag:blogger.com,1999:blog-655962722302095847.post8495234844156483003..comments2024-03-28T22:33:35.806+01:00Comments on Epiphany: Back to School (again)Peter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-655962722302095847.post-50018187929780780792017-10-15T19:22:56.426+02:002017-10-15T19:22:56.426+02:00THANK YOU both for your willingness to help with t...THANK YOU both for your willingness to help with the most basic of questions.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-19642050758854947142017-10-13T14:10:07.984+02:002017-10-13T14:10:07.984+02:00Hi Anon, I mix all my supplements in Grape Juice, ...Hi Anon, I mix all my supplements in Grape Juice, to try to mask the less than pleasant flavors. There are a few supplements I would like to try, like Berberine, Naringin, and TUDCA, but which I have not even attempted as they are so incredibly bitter. My daughter is fine with Agmatine in grape juice.<br /><br />As far as Cinnamon, Peter has provided the answer, and I would also add that from a flavor standpoint, Ceylon is so mild, that it is easy to give in larger doses (like 1/4 teaspoon X 2) as I'm giving now. <br /><br />Definitely only use Ceylon, for the reason Peter has given. <br /><br />No improvement seen yet, but its only been about a week.<br /><br />Best of luck!<br /><br />AJ Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-77427222219886639882017-10-13T09:29:43.604+02:002017-10-13T09:29:43.604+02:00Cinnamon is made from the bark of certain types of...Cinnamon is made from the bark of certain types of tree. Cheaper cinnamon, like Cinnamon Cassia, contains a toxic substance called coumarin. The content of coumarin in bakery products etc is regulated for safety reasons. If you are going to eat 3g a day of cinnamon you need to avoid the types that contain coumarin.<br /><br />This is why you should only use "true cinnamon", also known as Ceylon cinnamon. Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-25998437936350619612017-10-12T23:20:11.622+02:002017-10-12T23:20:11.622+02:00also does it have to be Ceylon cinnamon specifical...also does it have to be Ceylon cinnamon specifically? Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-54933221892604847492017-10-12T23:09:41.948+02:002017-10-12T23:09:41.948+02:00Hi AJ how do you mask the bitter taste of agmatine...Hi AJ how do you mask the bitter taste of agmatine powder?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-54382270587736593462017-10-11T20:32:17.623+02:002017-10-11T20:32:17.623+02:00D&G, there are comments on this blog from a UK...D&G, there are comments on this blog from a UK pediatrican who uses baclofen in Asperger's but was wanting to find research evidence to support its continued use. There was none specific to baclofen. <br /><br />There is now much more research on R-baclofen, in various types of autism.<br /><br />Baclofen that your doctor can prescribe is a mixture of R-Baclofen (the right handed version/enantiomer) and L-baclofen (the left handed version/enantiomer).<br /><br />This is just like with the antihistamine cetirizine, nowadays you can buy just the left handed version levoceterizine. <br /><br />If your doctor understands enantiomers he/she should be willing to accept evidence from the potent half of baclofen, which is R-baclofen (also called Arbaclofen).Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-79479993039077351642017-10-11T18:15:48.644+02:002017-10-11T18:15:48.644+02:00Peter or anyone,
I need evidence of Baclofen stud...Peter or anyone,<br /><br />I need evidence of Baclofen studied on children with Autism or at least with anxiety. I only come across Arbaclofen. Our doc will only prescribe Baclofen if provided with evidence of its use in children with Autism/Aspergers. Perhaps some in the community have access to such.<br /><br />Does such research exist?<br /><br />Many thanks,<br />D&G<br /><br /><br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-34424505327700860792017-10-11T10:00:01.595+02:002017-10-11T10:00:01.595+02:00AJ, I am glad your daughter is developing so well....AJ, I am glad your daughter is developing so well. Interventions like cinnamon/sodium benzoate do not seem to have any downside; this likely applies to agmatine as well.<br /><br />GABAb agonists like (R-) baclofen and Pantogam really do seem to benefit many people. Some with mild autism and some with severe autism. Your paper is from the MIT people who did try once to commercialize arbaclofen, but that effort failed after 10s of millions of dollars were spent. Baclofen and Pantogam already exist as drugs.<br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-17854921490335458622017-10-11T04:27:28.772+02:002017-10-11T04:27:28.772+02:00Hi Peter and community,
First, I really appreciat...Hi Peter and community,<br /><br />First, I really appreciated this article Peter, and I completely see my family's challenge in what you wrote. My #1 goal is to find interventions that will allow my 4 year old girl to continue to advance in her schooling at a pace similar to her peers, knowing that they are ahead in many areas (but not all). <br /><br />For this reason, I actually started Ceylon cinnamon at 1/4 teaspoon X 2 added to her daily "stack" about 3 days ago. Thanks for brining this up Peter, of the 3 areas I am trying to address (Cognitive, Speech, and Socialization), Cognitive is to me the most important. I'll keep everyone posted - I may raise the dose in a month or so if I see no impact at this dose)<br /><br />I've been so busy the last few weeks, I haven't had the chance to post, but Peter you had asked me if we had added Agmatine some time ago, and we had done so. My daughter keeps improving, albeit a steady pace, so it's hard to tell if Agmatine made any impact. <br /><br />In the meantime, we've done a few tests, waiting for those results, and are really hoping to get funding for genetic analysis. <br /><br />I also wanted to post a few interesting findings that add to what we know. The first is about Schizophrenia, but it's extremely interesting as for the first time, researchers have found a significant connection to the BBB, and there is research out there that ASD kids have altered BBB:<br /><br />http://www.nature.com/mp/journal/vaop/ncurrent/full/mp2017156a.html?foxtrotcallback=true<br /><br />The second is called "R-Baclofen Reverses Cognitive Deficits and Improves Social Interactions in Two Lines of 16p11.2 Deletion Mice"<br /><br />http://www.nature.com/npp/journal/vaop/naam/abs/npp2017236a.html<br /><br />And finally, those researches at King Saud University keep giving us interesting info, this time about upregulation of CXC and CC Chemokine Receptors on CD4+ T cells<br /><br />https://www.ncbi.nlm.nih.gov/pubmed/28986277<br /><br />Have a great night everyone!<br /><br />AJ<br /><br />Anonymousnoreply@blogger.com