tag:blogger.com,1999:blog-655962722302095847.post8457482365763252703..comments2024-03-29T10:24:53.156+01:00Comments on Epiphany: Why not Cocoa Flavanols for Autism?Peter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-655962722302095847.post-2558554432262325862017-01-15T21:25:49.272+01:002017-01-15T21:25:49.272+01:00I found an interesting webinar yesterday: http://m...I found an interesting webinar yesterday: http://mitomedical.com/2013/11/22/an-educational-webinar-about-autism-and-mitochondrial-function/<br />Basically this doctor explains the benefits of a combination of L-carnitine, B5, vit E and C to improve mitocondrial function, as it looks like a lot of asd kids have mitocondrial disfunction. ALA is also mentioned and there are already supplements for this on the market. <br />How is ALA different from NAC? I tried NAC and I tried L-carnitine and they just made my son worse: more hyperactive and more aggressive. I have been giving my son liquid Zeolite in drops and this has been really a game changer, but there is very little research on it and a lot of negative press. Some people doubt zeolite is a chelator, but what I am seeing is my son sweating buckets at night, a lot of flautulence, more poop and CALM! The other bonus is that since taking zeolite, my son can tolerate LiverLife, which he couldn't until now, not even one drop, whereas now he takes 15 drops without any side effects, so it must do something. Do you, or anyone out there have experience of this? I will keep going on with the zeolite until I see no more improvements, then I might be tempted to try ALA. Giovanna.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-86022187291741966422016-07-26T13:32:28.562+02:002016-07-26T13:32:28.562+02:00Some DAN doctors do have some strange ideas. ALA i...Some DAN doctors do have some strange ideas. ALA is used as a mainstream drug in many countries, where it is used at high doses and nobody is worried about old fillings.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-83464852045109187942016-07-25T20:17:11.937+02:002016-07-25T20:17:11.937+02:00Peter would you kindly answer is it a myth that AL...Peter would you kindly answer is it a myth that ALA CHELATES fillings in ones mouth and does it have to be taken at given hourly suggestion as the DANS PROPOSED.cant remember the new name that DANS now use.tAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-76734484361601513372016-01-27T09:30:13.066+01:002016-01-27T09:30:13.066+01:00In people with histamine intolerance, as opposed t...In people with histamine intolerance, as opposed to allergy, it looks like they may have a negative reaction to NAC. In people with allergy, but not apparent histamine intolerance, like my son, NAC does not appear to have any negative effects. NAC is widely prescribed to children in many countries as an anti-mucus therapy. So I think NAC should be seen as a safe antioxidant. ALA is very similar to NAC and if you cannot tolerate NAC, you will likely not tolerate ALA. <br /><br />If you are allergic to things like sodium benzoate and cinnamon, you are likely histamine intolerant (both are DAO inhibitors).<br /><br />To quote from an earlier post:-<br /><br />http://epiphanyasd.blogspot.com/2015/02/autism-schizophrenia-histamine.html<br /><br />Histamine degradation<br />=====================<br /><br />In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase (HMT) andoxidative deamination via diamine oxidase (DAO).<br /><br />HMT and uses S-adenosyl-L-methionine (SAMe) as the methyl donor. If SAMe is lacking HMT cannot degrade histamine.<br /><br />In the brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation. It is disputed whether diamine oxidase is found in the central nervous system. Some sources say it is not, but other studies specifically measure DAO levels in the brain, finding them elevated in schizophrenia.<br /><br />A common genetic polymorphism affects the activity levels of HMT in red blood cells. This can be tested for.<br /><br />People with low levels of DAO will not be able to degrade histamine in their body nor, it appears to me, in the brain.<br /><br />People with low levels of SAMe will not be able to degrade histamine as they should, that has crossed the BBB (blood brain barrier). Those same low levels of SAMe will have raised the inflammatory cytokines and reduced the anti-inflammatory cytokines.<br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-71273604866882869632016-01-27T02:59:11.601+01:002016-01-27T02:59:11.601+01:00I have read several places that NAC increases hist...I have read several places that NAC increases histamine levels. I am not a scientist and don't quite understand all the biological processes involved, but does is the rise in histamine levels significant enough to cancel out the antioxidant benefits? And/or does it make ALA or cocoa flavonoids a more beneficial choice?nhttps://www.blogger.com/profile/11541011138605463627noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-6125796365885597222015-10-04T17:43:40.380+02:002015-10-04T17:43:40.380+02:00Fascinating article and idea. I am sure we are onl...Fascinating article and idea. I am sure we are only just beginning to realize the potential of cocoa flavanols. I am very interested in the potential for treatment of stroke and Alzheimers also. Have shared on Twitter and FB.Edward Byrnehttp://cocoallegro.co.zanoreply@blogger.com