tag:blogger.com,1999:blog-655962722302095847.post8291381928990505547..comments2024-03-19T08:26:10.761+01:00Comments on Epiphany: “Autism treatments proposed by clinical studies and human genetics are complementary” & the NSAID Ponstan as a Novel Autism TherapyPeter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger36125tag:blogger.com,1999:blog-655962722302095847.post-30089256543347806792019-02-06T09:44:56.874+01:002019-02-06T09:44:56.874+01:00Celecoxib is a very widely used NSAID type drug. 1...Celecoxib is a very widely used NSAID type drug. 10% of all Americans have taken it and so of course there are reports of side effects, as there are with all blockbuster drugs.<br /><br />There are studies on the use of Celecoxib to treat schizophrenia and bipolar. There are people with autism in the US who take Celecoxib.<br /><br />Different people respond differently to individual NSAID type drugs. Some have side effects and some have none.<br /><br />The pragmatic approach would be first to see if it helps and then worry about how to safely use it long term. Ask your doctor about this. I imagine some people cycle its use to avoid side effects – so they make regular pauses.<br /><br />Baclofen at modest doses indeed help some people with mild autism, but not all of them.<br /><br />If Baclofen helps you would find out within a few days.<br /><br />I think Bumetanide is likely the GABA related drug that will help your son most, but the diuresis will disturb electrolytes and affect his potassium channelopathy.<br /><br />I suggest you continue reading up on the subject and then go back and talk to your doctor.<br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-35207074728974421672019-02-05T22:45:53.836+01:002019-02-05T22:45:53.836+01:00Once again, thank you for answering. I read a litt...Once again, thank you for answering. I read a little about this Celecoxib and it is a very encouraging drug, primarily when it comes to our mutations KCNQ3. Equivalent action is to the drug Retigabine which was a drug in this canalopathy, unfortunately, was withdrawn due to serious side effects (blue skin color) This mutation is combined also with migraine or neuropathic pain, therefore, the more I would like to try this drug, because my son sometimes cries a lot of time sometimes even a few hours and it is especially in the afternoon especially. Unfortunately, I did not find any information as long as this Celecoxib can be used, only those that represent 10 weeks research. This mutation is related to the protein, and here I come to the receptor GABAb and thus Baclofen what you think about it.? GABA with us does not work as it should only bad response to Benzodiazepines or Gabapentin but whether the problem lies in the GABA B receptor or GABAb?<br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-40237029829596361462019-02-01T13:46:13.942+01:002019-02-01T13:46:13.942+01:00A clever solution to discuss with your doctor migh...A clever solution to discuss with your doctor might include a potassium sparing diuretic (to raise K+ levels) and bumetanide to block NKCC1. You could then see if a drug like celecoxib gave an additional benefit via Kv7.3. <br /><br />You need to be aware that you child will be specially sensitive to a drop in potassium levels caused by bumetanide. So you have to go and take blood samples to monitor K+, this is always difficult, but particularly necessary if you also have a potassium channelopathy.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-50377260006011806352019-02-01T12:48:29.525+01:002019-02-01T12:48:29.525+01:00Agnieszka, firstly we need to highlight that my so...Agnieszka, firstly we need to highlight that my son represents just one sub-group of autism and that bumetanide responders may include more than one sub-group.<br /><br />In my son both Picamilon and a tiny dose (< SSRI dose) of Fluoxetine produce a negative reaction with a few hours.<br /><br />One researcher did suggest a strategy of "fixing" the GABA response with bumetanide and then "increasing GABA" - in lay terms.<br /><br />I think for many people with autism, bumetanide is only a partial solution to NKCC1/KCC2 miss-expression and so some show no response and others show a positive response, but not all the potential benefit. A more potent drug is needed. Perhaps Azosemide is that drug, or else we have to wait for Ben Ari to produce his next drug. We can also use an OAT3 inhibitor to boost bumetanide levels.<br /><br />I think "partial bumetanide responders" should indeed be wary of drugs/supplements that "increase GABA" or the response to it. The effect will be apparent very quickly, so no harm done.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-84339242631680066862019-02-01T11:26:34.949+01:002019-02-01T11:26:34.949+01:00Peter, with regard to the negative effects of &quo...Peter, with regard to the negative effects of "increasing GABA" drugs: do you mean the effects in your son when he was already on bumetanide? Would it mean that bumetanide is not able to reverse the paradoxical GABA function enough? So, is it better to stay away from this kind of drugs in a person who is a bumetanide responder? I guess there can be some long term effects which would not be apparent after the first few doses.Agnieszka Wroczyńskahttps://www.blogger.com/profile/04738535364585304041noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-26716755374719230562019-02-01T08:58:10.859+01:002019-02-01T08:58:10.859+01:00You also need to be sure whether your son’s geneti...You also need to be sure whether your son’s genetic issue requires an activator or an inhibitor of this ion channel. Both are possible and both are treatable. It is easy to get things back to front.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-73228651265146870402019-02-01T07:57:15.946+01:002019-02-01T07:57:15.946+01:00Also, recall that the whole point of Bumetanide in...Also, recall that the whole point of Bumetanide in autism is that in those people GABA is working in reverse and so GABA is excitatory and not inhibitory. In such a person Gabapentin might eventually trigger epilepsy.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-11936191644763314932019-02-01T07:37:53.978+01:002019-02-01T07:37:53.978+01:00Do not be confused, just look at the other effects...Do not be confused, just look at the other effects of Gabapentin. In my son all drugs that “increase gaba” have a negative effect and increase agitation. Find a Kv7.3 activator that does not affect GABA so directly.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-8789035468652076952019-01-31T22:43:16.911+01:002019-01-31T22:43:16.911+01:00Thank you very much for your answer . I ask, becau...Thank you very much for your answer . I ask, because we take Gabapentin only for 2 days and the reaction is similar to Benzodiazepines, increased agitation, and I'm confused, maybe Bumetanide will work as it should.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-29367107052794837472019-01-31T20:06:35.535+01:002019-01-31T20:06:35.535+01:00Your gene encodes the Kv7.3 ion channel, which is ...Your gene encodes the Kv7.3 ion channel, which is important in the regulation of neuronal excitability and dysfunction can be associated with epilepsy, aggression, absence seizures and issues with vision.<br /><br />This ion channel combines with either Kv7.2 or Kv7.5.<br /><br />Gabapentin activates Kv7.3.<br /><br />Many other drugs activate or inhibit Kv7.3<br /><br />Celecoxib enhances Kv7.2/7.3 and Kv7.3/7.5 currents<br /><br />14 drugs are listed as activators or inhibitors of Kv7.3 on this very long page below.<br />https://www.genecards.org/cgi-bin/carddisp.pl?gene=KCNQ3<br /><br />So you have a lot of choice.<br /><br />Since your son has a paradoxical reaction to benzodiazepines, that would make him likely to respond well to bumetanide.<br /><br />You and your doctor can look up drug interactions. I looked up bumetanide and gabapentin and found no contraindication.<br /><br />https://www.drugs.com/drug-interactions/bumetanide,bumex.html<br /><br />I am not a doctor, but I could not see a reason why you could not take bumetanide with a Kv7.3 activator.<br /><br />You will inevitably have to try out different drugs and combinations to find what works best for your son.<br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-32719745064514997642019-01-31T17:46:53.413+01:002019-01-31T17:46:53.413+01:00I have a son of 5 years (Autism) recently diagnose...I have a son of 5 years (Autism) recently diagnosed with him channelopathy KCNQ3 (son of epileptic seizures does not have and never had, only the EEG record presents a continuous electrical discharge during sleep.) We have received Gabapentin treatment for a while, a dose of 200 mg for the night to be increased (there are studies in which it presents that opens kcnq3 channels). My question is whether you can take Bumetanide with Gabapentin? The son has stories of a paradoxical reaction to Benzodiazepines. Bumetanide acts on GABAA (chlorine, pore) and Gabapentin on GABAB which is coupled to the G protein (the kcnq3 mutation is bound to the protein). Mr write about NSAID (Mefenamic acid) and Bumetanide as a treatment for genetic autism associated with canalopathy. In our case, would it make sense to introduce both at once or would it be safe? Sam Meclofenate also opens the KCNQ3 channels, but I decided to introduce GBP from the disturbing EEG. I am asking for help, please.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-76033475651535373712017-11-02T14:37:43.484+01:002017-11-02T14:37:43.484+01:00As a comment to genetics vs other contributing fac...As a comment to genetics vs other contributing factors in autism:<br /><br />Some of you might have noticed that calcium-dependent chloride channels (anoctamins) were genetically significant in autism, as per Knut Wittkowskis paper:<br /><br />"For the HFA [High functioning autism] cases, however, a second anoctamin, ANO2, located on the other arm of chromosome 12, competes with ANO4, for the most significant gene among the result"<br /><br />This might still be relevant in autism even without that genetic dysfunction, especially if we are talking about autism related to autoimmunity. Compare with the results in the MS study below:<br /><br />Anoctamin 2 identified as an autoimmune target in multiple sclerosis (2016)<br />"Thus this study represents one of the largest efforts to characterize the autoantibody repertoire within MS. The findings presented here demonstrate that an ANO2 autoimmune subphenotype may exist in MS"<br />https://www.ncbi.nlm.nih.gov/pubmed/26862169 <br /><br />This is just one example, I am sure there are other antibodies involved in some autisms. Btw, soes anyone know if there exists antigene/antibody test panels?<br /><br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-46445651118751825702017-08-04T22:35:49.906+02:002017-08-04T22:35:49.906+02:00Oh, now I see that Gleevac/Imatinib is used as a c...Oh, now I see that Gleevac/Imatinib is used as a chemotherapy for chronic myeloid leukemia too. It is probably used then for many different conditions. Just thought that the connection with autism and mastocytosis and leukemia could have something to tell. It is easy to see patterns everywhere. :-)<br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-74255354131815096862017-06-15T22:34:48.385+02:002017-06-15T22:34:48.385+02:00Regarding the mention of Gleevac in this post as a...Regarding the mention of Gleevac in this post as a (not recommended) way to block growth factors for ASD kids.<br />I just learned that Gleevac/imatinib sometimes are used for systemic mastocytosis. Can someone explain the link?<br /><br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-22574120148280502482016-02-01T19:14:55.558+01:002016-02-01T19:14:55.558+01:00Peter, I am happy for you that PECS was fun for yo...Peter, I am happy for you that PECS was fun for your son. My son absolutely hated it. Besides, ABA therapists warned us beforehand that PECS do not facilitate speech, but they do provide the kid with the way of communication once he is ready for it. They told me he is non-verbal and he will never talk, because he did not talk before the regression, like other kids did. There is no upside for me in ABA therapy. He found his own way of communication now that he is ready for it. PECS do not promote speech. Academically he is very smart and does not need any training. He needs help with things like food, he never ate food on his own, not even with his hands. And ABA can not help with that, the same way as it can not help with recognizing emotions, promoting initiative and things like that. He hates touching any type of food and seems to be disgusted by it. He does not chew on his own.His highest point in his development was between 12-18 months old when he would grab a piece of bread and nibble on it. He has not done that in two years, but just recently he started doing it! It coincided with starting him on Diamox and Mefenamic acid. I am not sure which one of the two helped. I will stop the Mefenamic acid after 7 days on it and will see if these changes stay. <br />So far, drugs have been very helpful with his issues. I do not see how any form of therapy would help with appetite, mood, initiative, etc. Leaving him alone promotes initiative. The other thing that helps is keeping the interactions to the minimum, especially contacts with other kids. That helps with his self-esteem and builds up his confidence, because he does not compare himself to the normal kids and it does not make him feel inadequate. Because the autism, at least some forms of it, can be cured. But the neurotic disorders created by forced socialization and by comparing oneself to the normal kids are not curable. I do not want to add to his problems. I will stick with something that worked so far - plenty of alone time for him and the supplements/drugs that work. <br /><br />Thank you very much for this blog! Finally I am starting to see that his condition is not permanent and there are drugs that can improve it. He is finally returning to the highest point of his development that was at 12-18 months old. For most kids eating with hand was a regression. Sadly, for my son the same thing is a sign of progress. His appetite is improving, he is starting to request food, he is not afraid to touch it anymore. Those are the things that even OT could not help him with. In fact, all of the therapies we attempted had brought zero improvements in any areas. Supplements brought some improvements, but not as much as the drugs you listed in your pill for autism. I feel fortunate I found your blog. Because the real autism, like in my son, is very rare. Most sites share info on treating regressive autism and it has nothing to do with the true autism my son has. <br /><br />Peter, have you ever tried Diamox on your son? I think it's helping my son, from what I've seen in the 5 days I am giving it to him. I am wondering can it be given on a permanent basis or I should take breaks, like with HBOT?<br /><br />Best regards,<br /><br />PollyPollyhttps://www.blogger.com/profile/17169489289012330736noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-19043163365009275222016-01-28T22:52:57.007+01:002016-01-28T22:52:57.007+01:00Polly, interventions can be made to be fun and not...Polly, interventions can be made to be fun and not stressful. It all depends on who is the therapist. It can be a parent.<br /><br />Maybe look at the Hanen Program.<br /><br />www.hanen.org/<br /><br />PECS is actually really clever and much more than just handing over a picture of what you want. The training course lasts two days. Kids LOVE it. It shows the child that communication is worthwhile and hence in his interest. Once there is active communication, speech often then follows.<br /><br />Ultimately some children need help to be drawn out of their isolation, because it may otherwise not happen. This can be an fun uplifting experience, it does not have to be a stressful experience, like a visit to the dentist. <br /><br />It would be great if there was a pill for this.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-77163872866740270752016-01-28T20:46:09.510+01:002016-01-28T20:46:09.510+01:00Thank you for your reply, Peter. I do not think th...Thank you for your reply, Peter. I do not think therapy makes any difference in autism. I read lots of stories of non-verbal kids receiving 40 hours a week ABA therapy for decades and remaining severe and non-verbal. We tried to introduce PECS 1.5 years ago and it only made the matters worse. I am not going to stress him out like that again, because stress is one of the triggers of autistic symptoms. Your son and other kids started talking in spite of the stress of ABA, not thanks to it. They were ready to start talking at that point and that would have happened regardless of the therapy. My son is more damaged than most kids, because the assault on his brain happened earlier than in most kids, even before he was born. <br />He is communicating by bringing me objects - his bottle, TV remote, shoes, etc. I do not see how it would make any difference if he brings me a picture of a remote, or of a bottle or of the shoes? He is very smart and loves learning, for example he likes to show me the animals on the wall of his room, he wants me to ask him which animal is where. After 5 weeks of ABA therapy 1.5 years ago, he completely lost interest in learning new things, and became resistant and psychotic. I think ABA therapy does not make any difference in less damaged kids, they improve on their own, but it affects severe kids, like my son, in a very negative way and makes them even more severe. <br />All of the progress so far has come from one supplement or the other, and none from the communication therapies. I just need to continue looking for the appropriate supplements to address his particular issues.<br /><br />Thanks to clonazepam, his mood has improved and there is no more electrical activity during his sleep. I hope that by giving him this drug in low doses it will prevent him from developing real siuzures in the future. That was a very good addition to his supplements. Thank you for that! Bumetanide has lifted the fog, he responds to the same requests much faster, like to turn on the coffee machine, to flush the toilet, to show me letter A. Before he was taking a long time before responding, and now he does it right away. It happened 2 weeks into giving him Bumetanide. I do not see any other changes lately, even though I continue with both of these drugs. I tried other drugs that are supposed to help with speech, like Galantamind and Piracetam, but there was no changes in speech. Perhaps he is one of those kids that I read about, who never start talking, even on lots of ABA. Perhaps the damage to that part of his brain that is responsible for speech is irreversible :( I will continue with my low stress, minimum interaction approach for now. It works the best for him, because any interaction, like with the strangers on the street, causes an intense stress and increased stimming in him. I do not see any upside in the forced socialization, but lots of regression. I am not sure what I am going to do when it's time to enroll him in school, because he is nowhere near ready to attend any schools and he does the best when he is left alone and not bothered. Leaving him alone triggers his own initiation of communication. Any forced form of communication, like ABA, ends in a disaster and results in him completely shutting down and regressing. I wish there was another way to treat his condition, but so far the only thing that worked is to address it medically, with drugs and supplements. Pollyhttps://www.blogger.com/profile/17169489289012330736noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-87214416520478545312016-01-28T10:43:55.777+01:002016-01-28T10:43:55.777+01:00Polly, Ponstan (mefenamic acid) is widely used by ...Polly, Ponstan (mefenamic acid) is widely used by children in many countries. One reader of this blog from Greece found it always worked differently (better) than other NSAIDs when her son was young. The dosage used in those countries is 100mg in 2 to 4 year olds. All NSAIDs can cause GI side effects. Trying it for a few days falls within the normal usage.<br /><br />If you continue use of Bumetanide and Low dose Clonazepam, there should be a continued cognitive improvement. As long as you combine this with lots of therapy to encourage communication (like PECS), you will maximize your chances of speech developing.<br /><br />I would now focus on the communication therapy, rather than more pills.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-77769322398921989592016-01-28T05:39:17.619+01:002016-01-28T05:39:17.619+01:00Hi Peter,
I have tried Bumetanide and Clonazepam ...Hi Peter,<br /><br />I have tried Bumetanide and Clonazepam on my son and I found both of them working just like you described in your table - clonazepam after 3 days and Bumetanide after two weeks - the fog has lifted. <br />I also trialed Pantogam + Carnosin, Piracetam and Galantamine, but no visible effect from either one of them. <br />I am considering trying Mefenamic Acid or Atorvastatin next. Which one would you recommend trying first?<br />Also, we are in the middle of the homeopathic allergy treatment, so I would prefer using the drugs that do not affect his response to the homeopathy. I know that Atorvastatin suppresses cytokines, which would affect the body's response to homeopathic remedy histaminum that he is taking. I am taking it as well, and I notice a huge effect on me after each dose. I feel like I am coming down with a flu, but it only lasts one day. I had a bad inflammatory response to the flu shot in the third trimester of my pregnancy, which triggered my son's autism. I guess this homeopathic remedy causes my body to process the flu virus from the vaccine, 4 years after I had it. I do not see the same response in my son, unfortunately. But I would like to postpone any of the allergy drugs for now, waiting for the end of the detox, in a month from now. <br />Also, I read about mefenamic acid usage online and they have a warning of not using it for more than 7 days in a row. How do you feel about long-term usage of this drug?<br /><br />How much of mefenamic acid would you give to a kid who is almost 4? <br /><br />Thank you for your blog, it helps a lot. But my son is almost 4 and he is still completely non-verbal and I am starting to feel pretty desperate, knowing that some areas of his brain might be irreversibly pruned. I am trying every possible drug to initiate speech, but so far all my efforts are not successful. <br />Which one should I try next? I am trying to avoid the allergy drugs right now, because of the homeopathic treatments. <br /><br /><br />Thank you,<br /><br />PollyPollyhttps://www.blogger.com/profile/17169489289012330736noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-83489262817492101952016-01-01T19:18:12.060+01:002016-01-01T19:18:12.060+01:00Hi, I just received Ponstan in the mail and was wo...Hi, I just received Ponstan in the mail and was wondering if there are further insights from readers? Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-62335139853385234662015-12-21T10:12:21.506+01:002015-12-21T10:12:21.506+01:00I think both are safe, but the one with the clinic...I think both are safe, but the one with the clinical trials to support it, is Bumetanide. This drug is used in 3 week old babies.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-7028971234808081692015-12-21T00:25:21.356+01:002015-12-21T00:25:21.356+01:00Thanks for your response.
Which of the 2 would you...Thanks for your response.<br />Which of the 2 would you rate safer for a 4 years old boy?<br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-51018083458771925152015-12-20T15:03:37.579+01:002015-12-20T15:03:37.579+01:00You can get bumetanide without prescription in som...You can get bumetanide without prescription in some countries, for example Spain. Clonazepam is a substance some people abuse, and so will not be easy to obtain without a helpful doctor.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-91231833117815520022015-12-20T14:52:26.292+01:002015-12-20T14:52:26.292+01:00Hi peter,
I really like your very scientific for...Hi peter, <br /><br />I really like your very scientific forum here.<br /><br />I just found some more info linked to GABA from Harvard<br /><br />http://www.sciencedaily.com/releases/2015/12/151217130500.htm<br /><br />My son is 4 years old and has autism and he does talk since half a year.<br /><br />The most common behaviour I see is lining up things<br />with usually the same toys and wanting things the same. Tantrums occur often when things change.<br />He has periods on the day that it is almost non existing and sometimes it is very bad. We stopped milk half a year ago which improved things a bit.<br />He was born at 32 weeks at 2 kg with few complications but he did have severe stomach cramps in the first half year and constipation from 2 years till 3.5 year. <br />Since half a year I use many of the DAN adviced supplements. It seems to help a bit but I am not sure as it could be natural change. Last week I had the first appointment with a DAN doctor who is doing some tests on urine, stool and hair. <br />Before the test results she already put him on<br />Beta 1,3 glucan and Citramesia.<br /><br />I wonder if anybody recognizes a strange skin behaviour while he does not have any skin allergies.<br />There is a sudden appear of temporarily red spots/red skin on his eyebrow and <br />forehead while he has a tantrum. The spots initially look like they have been there for days but after the tantrum is gone they just disappear after 10 minutes. I really wonder what that could be and if that is an indication of something that needs attention. I asked his doctor but he did not have any idea.<br /><br />Does anybody know where to buy Bumetanide or Clonazepam without doctor prescription? <br />I am in Europe.<br />I would like to test these and feedback the results.<br /><br /><br /><br /><br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-37330149102470626862015-12-04T09:52:57.144+01:002015-12-04T09:52:57.144+01:00Some people with autism do take low dose aspirin.
...Some people with autism do take low dose aspirin.<br /><br />I think to be sure of maximizing the chance of getting the specific benefit that Knut proposes, Mefenamic acid (Ponstan) is likely the best choice.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.com