tag:blogger.com,1999:blog-655962722302095847.post8265477920824995457..comments2024-03-29T10:24:53.156+01:00Comments on Epiphany: Accept Autism or Treat It?Peter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger35125tag:blogger.com,1999:blog-655962722302095847.post-90155101811171082712018-05-23T14:08:44.886+02:002018-05-23T14:08:44.886+02:00Forgot to add, cordyceps is one of the best things...Forgot to add, cordyceps is one of the best things I have tried to but currently not using due to costs of the new things im trying and using.<br /><br />More evidence that I am right about cordyceps holding potential (since its an AMPA PAM/positive allerostatic modulator):<br /><br />______<br /><br />Fresh from the press!:<br /><br /><br />Pharmacological modulation of AMPA receptor rescues social impairments in animal models of autism (may 2018)<br /><br />https://www.nature.com/articles/s41386-018-0098-5<br /><br />"Collectively, these results provide insight into the role of AMPARs in the underlying pathophysiological mechanisms of ASD, and demonstrate that modulation of AMPAR can be a potential target for the treatment of social behavior deficits associated with ASD"<br /><br />And voila, piracetam is also a AMPA PAM.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-10716651416564248252018-05-23T13:34:41.048+02:002018-05-23T13:34:41.048+02:00NO boosters/blood flow enhancers:
Time released c...NO boosters/blood flow enhancers:<br /><br />Time released citrulline - improves mood, less effort in finding the right words and relieves sore muscles due to stress.<br /><br />Glycine propionyl l carnitine - proven to reduce lactic acid (commonly high in pretty much every form of autism) and a potent NO booster.<br /><br />Tine dose of krilloil (once to twice per week) - contains astaxanthin, very potent relieve of brain fog/brain inflammation, crystal clear thinking, love/hate relationship with this one as its both over energizing and seems to make one overconfident/arrogant when taken too often during the week, drastic improvement in eye sight and skin health (this is very noticable).<br /><br />Memantine: both good and bad, complete annihilation of stress due to its ability to effect LTP, more joy in things, more in the moment, downsides: can be mild dissociative, inability to give new memories a meaning (very scary this one) and one of the reasons I discontinued, absolutely not withdrawal symptoms noticed.<br /><br />HMB, doesnt do much to increase positive emotion, but keeps negative emotions away, protection of muscles during stress, lowers CK, LDH.<br /><br />Next on my list to try:<br /><br />Oleamide: effects cannaboid receptors, sleep aid, potentiates 5ht2a/5ht2c receptors.<br /><br />Bumetanide: obviously :)<br /><br />Psilocybin: Used this in the past once and while on it, I did feel increase affection towards others, lots of research currently being done on this for its ability to strong affect the amygdala.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-37311842558095817622018-05-23T13:34:10.590+02:002018-05-23T13:34:10.590+02:00Thought id chime in as I have hopped back on the r...Thought id chime in as I have hopped back on the reuteri atcc6475, this time at the 'shocking' dose 8 tablets (4 tablets bidaily per day), about a week in now.<br /><br />I was sceptic in the past about it, but it does seem to be pro-emotional, this is a misconception about the oxytocin neuropeptide, it not only increases trust, but also possibly hate, jealousy and such.<br /><br />I noticed this about 4 weeks in, that I was approachable and I noticed my inner speach returned along with emotions such as both liking someone aswell as disgust (I was never able to fake this, so this is impossible to be placebo).<br /><br />Reuteri feels more as emotional intensification both for good and bad. I do feel that while on it I feel more of an urge to defend my opinion and stick to it, rather than trying to get away from a situation. Reuteri also makes me realise that I am actually alone, this made me somewhat depressed and this leads to an increase in motivation in me to look for social support. This is also a reason how I know its working, instead of my normal socialy withdrawal when theres something wrong with my life I actually seek help now! More spontaneous behavior also, for example I used to have a strong food regime what I would stick to, now since starting reuteri I sporadically ORDERED FOOD, while many of you might think whats so special about that, it means I stick less to routines and have more flexibility and openess (both for love and harm).<br /><br />Piracetam Im also still on, and it seems to improve the joy I have in life, thought it definatly needs least twice per day dosing as the duration seems ~3-4hours.<br /><br />CO-Q10, this helps, but going over 200mg per day seems to be oddly dulling (Q10 is proven to improve social and playing behavior in studies on kids with autism).<br /><br />Sulforaphane, currently not using this one, but this one is great for brain inflammation and stability, bit like NAC but that gave me side effects after longer use (blood noses and all that which freaked me out - 23andme results did show I have multiple SNP's with regard to blood clotting, VKCOR one aswell and yup I did have a horrible exerpience on K2, BEWARE if you have aspergers.)<br /><br />Vitamin D3, potent effect but blood levels build up fast, pro-social and calming with acute dosing but it is unsustainable due to blood levels building up...<br /><br />Oxytocin nasal spray (40-80iu/day): Unfortunatly this seemed to have somewhat inconsistent effects for me, but I believe this is due to me inhaling it which is the wrong way to use, theres videos on youtube how to properly use it, those who want to try it definetely look at the videos how to use it proper. Might give this one another chance and use it properly this time.<br /><br />Magnesium citrate paired with vitamin c and eggs: cholesterol, vitamin c and magnesium are a must for oxytocin production.<br /><br />Magnesiumoil (sleep aid for me), very calming unlike magnesium citrate, great for natural sleep, works far better for me than melatonin.<br /><br />Inositol (upregulates 5ht2a): calming effect, ability to 'let go', downsides: short duration and gives the shits in higher doses.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-27821298116419144762018-05-23T09:53:23.376+02:002018-05-23T09:53:23.376+02:00MH, I am emphasizing increasing cognitive function...MH, I am emphasizing increasing cognitive function because this is easy to measure and hard to argue against doing. Some parents find the most important gains from bumetanide are social and emotional.<br /><br />Monty is very affectionate, happy and smiling. His main remaining autistic characteristic is that he does not talk a lot, he just says what he wants and answers direct questions. No gossiping or chit-chat. <br /><br />If the problems are primarily social, as in true Asperger's (high IQ). Then it is a case of making very small changes, like our reader Aspie 1983 is doing. This is going to be a very personalized therapy.<br /><br />Things like oxytocin would have a mainly emotional impact, but anything that helps in autism is likely to have a social benefit. <br /><br />So there are no easy answers. I only know what works in my son.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-45238406617520990912018-05-23T05:37:14.565+02:002018-05-23T05:37:14.565+02:00If anyone would like to weigh in, would appreciate...If anyone would like to weigh in, would appreciate it. This is just more a question -- after you have achieve cognitive gains -- is there still a lot of residual social issues that may not be overcome? In these circumstances what are the big wins?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-35946403462447445102018-05-21T06:19:43.684+02:002018-05-21T06:19:43.684+02:00Peter, what are the biggest wins for increased soc...Peter, what are the biggest wins for increased social aptitude? Is your sense that is it increasing intelligence and with that will come better know-how socially. For Monty, it sounds like his intelligence has increased, better with-it ness and better behavior for sure. How has his social interactions (besides not getting upset, etc) improved and what has been biggest driver? I know it is different for different segments. Last, which posts are the best for social improvements? Thanks! MHAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-30429197884530382592018-05-18T09:42:15.955+02:002018-05-18T09:42:15.955+02:00Yes, I am very thankful that there actually is so ...Yes, I am very thankful that there actually is so much relevant research for me to work on.<br />But it surely answers the question "How many things can go wrong in autism?" Also, it makes me think how discouraging it must be for doctors to try to treat this, even though the condition is very well defined.<br />I'll have some digging through the gene list to do, and will share both that and the highlights when finished. At a preliminary glance it actually looks like the opposite to "excitotoxicity/oxidative stress" which is very intriguing. But it could also be that much of this list reflects what the body tries to do to counteract it.<br /><br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-32280941877973634642018-05-17T21:18:01.431+02:002018-05-17T21:18:01.431+02:00Thanks Peter,I will go with Diamox,he has already ...Thanks Peter,I will go with Diamox,he has already use it with no side effects and lamotrigine scares me,by inhibiting glutamate, the dopamine system is removed from the inhibitory influence of glutamate,increasing dopamine levels in striatum and causing stereotipic behavior.<br />ValentinaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-41054319576978617202018-05-17T18:18:31.492+02:002018-05-17T18:18:31.492+02:00Diamox with bumetanide was an earlier idea of mine...Diamox with bumetanide was an earlier idea of mine, since Diamox acts on the AE3 exchanger and so should further reduce chloride within neurons, but in my son Diamox causes reflux. Some people do use this combination without side effects.<br /><br />Lamotrigine is a widely used anti-epileptic drug and may very well help with absence seizures.<br /><br />It is all about getting the good effects, without making anything else worse.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-47745584802251455312018-05-17T17:30:24.191+02:002018-05-17T17:30:24.191+02:00Peter, between Diamox and Lamotrigine, what would ...Peter, between Diamox and Lamotrigine, what would you choose?Diamox can be combined with bumetanide?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-39195962579455953852018-05-17T14:31:57.672+02:002018-05-17T14:31:57.672+02:00Valentina, here is a paper that reviews the many o...Valentina, here is a paper that reviews the many options:-<br /><br />Current and emerging treatments for absence seizures in young patients<br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716601/<br /><br />I don't think anyone can predict which therapy will be the most effective and well tolerated. You have to be careful.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-22998886321438464752018-05-17T13:46:23.951+02:002018-05-17T13:46:23.951+02:00Ok,thanks,could I use acetazolamide until I get Za...Ok,thanks,could I use acetazolamide until I get Zarontin in B.A?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-55927381160758451022018-05-17T10:44:47.347+02:002018-05-17T10:44:47.347+02:00Ling, that list should help move you in the right ...Ling, that list should help move you in the right direction. <br /><br />It looks like bumetanide helps in many types of cognitive loss (fragile X, Downs etc). The latest study in Fragile X showed a disease changing effect of bumetanide, if taken when very young (in mice). ie while the brain is still developing.<br /><br />If it was me, I would try bumetanide. <br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-65219400597030805602018-05-17T10:39:57.674+02:002018-05-17T10:39:57.674+02:00Valentina, I would be careful and listen to the ne...Valentina, I would be careful and listen to the neurologist. Finding a nearby country with Zarontin is likely the best option.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-39333055800349216102018-05-16T21:53:47.674+02:002018-05-16T21:53:47.674+02:00Sorry,baclofen is a Gaba B agonistSorry,baclofen is a Gaba B agonistAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-22633157711844334512018-05-16T21:28:42.190+02:002018-05-16T21:28:42.190+02:00Peter, do you know about Gaba B antagonists as ant...Peter, do you know about Gaba B antagonists as anti absence seizure drugs and cognitive enhancers?Gaba A agonists like baclofen would worsen this type of seizures. <br />ValentinaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-22757157748613702832018-05-16T16:08:22.024+02:002018-05-16T16:08:22.024+02:00It is available in many countries, try in Argentin...It is available in many countries, try in Argentina.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-76978018867934089402018-05-16T13:26:50.271+02:002018-05-16T13:26:50.271+02:00Picture of the day: "Frustrated mice"
h...Picture of the day: "Frustrated mice"<br /><br />https://www.researchgate.net/figure/Dopamine-DARPP-32-feedback-in-cAMP-signalling-in-frustration-like-behaviour-The-green_fig1_266327132<br /><br />I just found a list of 120+ genes that are dysregulated in my daughter, including 23 ASD genes... <br /><br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-86303651778297009362018-05-16T13:24:35.020+02:002018-05-16T13:24:35.020+02:00Peter, Zarontin is discontinued,there's no mor...Peter, Zarontin is discontinued,there's no more alternatives.<br />ValentinaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-36713302817136663212018-05-16T10:13:13.074+02:002018-05-16T10:13:13.074+02:00Tyler, inulin, sodium butyrate and probiotic bacte...Tyler, inulin, sodium butyrate and probiotic bacteria that produce butyric acid are indeed very interesting. Given they have already been adopted into animal feed, it is odd that humans have not followed suit. <br /><br />It must depend on how much butyric acid you start with. When I trialed sodium butyrate and inulin, there was no obvious effect. But I will try inulin again to see if it improves pollen allergy. Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-30761609433175277062018-05-16T09:41:59.888+02:002018-05-16T09:41:59.888+02:00Here is another interesting fiber study on immune ...Here is another interesting fiber study on immune activation when challenged by a flu virus (in mice):<br /><br />Press Release:<br /><br />https://www.sciencedaily.com/releases/2018/05/180515113805.htm<br /><br />Paper:<br /><br />https://www.cell.com/immunity/fulltext/S1074-7613(18)30191-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761318301912%3Fshowall%3Dtrue<br /><br />What is most interesting is that a high-fiber diet (inulin) selectively dampened excessive innate immune activation in the lungs (which can harm a lot of tissue), while enhancing adaptive immunity by boosting CD8 T cells.<br /><br />The experiments did not just test fiber, but also short-chain fatty acids directly in the form of sodium butyrate supplementation, so it appears from the results that either supplementing fiber or sodium butyrate may achieve similar outcomes with respect to immune regulation.<br /><br />I still see parents talking about all of the restrictive things they do with regards to food in the hopes of dealing with gastrointestinal health, but in the process totally neglect soluble fiber intake which is probably going to be pretty low on a restricted diet. If parents are worried about supplementing various resistant starches to the diet of their child because of some odd idea like it promoting candida overgrowth or something like that, they should at least be able to just use sodium butyrate even though I firmly believe supplementing dietary fiber is a better route (doing both fiber and sodium butyrate within certain parameters might be an idea to pursue as well).Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-38339315000378948162018-05-15T22:04:18.843+02:002018-05-15T22:04:18.843+02:00Perhaps not very new information, but still, one s...Perhaps not very new information, but still, one step closer to find the right interventions for the right autism:<br />"S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice" (2018)<br /><br />https://www.sciencedirect.com/science/article/pii/S089203621730154X<br /><br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-22917804446577500952018-05-15T19:43:08.734+02:002018-05-15T19:43:08.734+02:00Thanks Peter, I can get Zarontin from Pfizer,he is...Thanks Peter, I can get Zarontin from Pfizer,he is weaking up many times at night.<br />ValentinaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-30188577638994862262018-05-15T19:12:31.925+02:002018-05-15T19:12:31.925+02:00Valentina, ask your neurologist about ethosuximide...Valentina, ask your neurologist about ethosuximide (Zarontin). This is the other common therapy for absence seizures. This might have less side effects than valproate.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-69979736351310575392018-05-15T18:58:16.986+02:002018-05-15T18:58:16.986+02:00Peter, my son is presenting rolling eyes, the famo...Peter, my son is presenting rolling eyes, the famous upgaze, I suspect absence seizures, i don't want to return to valproate,his cognition is much better now and don't want to keep affecting mitochondria.What could i try?<br />ValentinaAnonymousnoreply@blogger.com