tag:blogger.com,1999:blog-655962722302095847.post7586015119410062575..comments2024-03-28T22:33:35.806+01:00Comments on Epiphany: Sulforaphane Research in Japan – Cognitive Deficits and SchizophreniaPeter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger30125tag:blogger.com,1999:blog-655962722302095847.post-90407812381108453762018-05-21T06:51:31.178+02:002018-05-21T06:51:31.178+02:00So please advise how much sulforaphane is produced...So please advise how much sulforaphane is produced for each capsule of Avmacol ingested? That's the important question.Christine Hhttps://www.blogger.com/profile/06511740408810243824noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-4196964333532288712018-05-21T06:50:08.266+02:002018-05-21T06:50:08.266+02:00This comment has been removed by the author.Christine Hhttps://www.blogger.com/profile/06511740408810243824noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-30976033600377471092018-05-21T06:48:37.852+02:002018-05-21T06:48:37.852+02:00EnduraCell actually claims that 1000 mg of the pro...EnduraCell actually claims that 1000 mg of the product yields around 20 mg sulforaphane. This is by far the highest sulforpahane-yielding broccoli sprout product available anywhere. Dont compare this with products marked as SGS - or sulforaphane glucosinolate - or TruBroc, all of which are simply the glucoraphanin precursor and devoid of the myrosinase enzyme.Christine Hhttps://www.blogger.com/profile/06511740408810243824noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-81200256941185780392018-05-21T06:44:07.413+02:002018-05-21T06:44:07.413+02:00There is a way to be sure. Use a nutraceutical-gr...There is a way to be sure. Use a nutraceutical-grade 100% whole broccoli sprout supplement like EnduraCell and you will know EXACTLY the yield of sulforaphane in each dose. Food-grade products do not test - but nutraceutical-grade products do. Check out EnduraCell which is an Australian company founded by a sulforaphane-specialised scientist.Christine Hhttps://www.blogger.com/profile/06511740408810243824noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-72293067360358316302018-05-21T06:40:38.047+02:002018-05-21T06:40:38.047+02:00In fact, every single batch of EnduraCell is teste...In fact, every single batch of EnduraCell is tested multiple times during and after manufacture to ensure that the bioactives in the broccoli sprouts are retained during processing and for the shelf life of the product. Keep in mind that not every patient's condition has the same cause and in cases where a product does not appear effective, it may be because this was not the appropriate product for that patient. Christine Hhttps://www.blogger.com/profile/06511740408810243824noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-802033007127284072018-01-03T08:06:36.114+01:002018-01-03T08:06:36.114+01:00Yes you can mix the broccoli with applesauce or an...Yes you can mix the broccoli with applesauce or anything else that is not hot.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-42563868175346484632018-01-02T22:36:40.154+01:002018-01-02T22:36:40.154+01:00Hello Peter, I have just got my first batch of Sup...Hello Peter, I have just got my first batch of Super Sprouts powder for my son, Age 4 with ASD. Would it be Ok to just mix the powder straight into an apple sauce or one of those fruit/veggie Blends? (same texture as applesauce)? or do I need to add the powder straight to water and then dump the mixture into the applesauce? I guess essentially what I'm asking is can I just stir 2.5ml of sprout powder straight into an applesauce or fruit squeeze?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-75247577235069531672017-03-10T18:14:14.763+01:002017-03-10T18:14:14.763+01:00I am wondering how the enzyme works after entering...I am wondering how the enzyme works after entering the stomach. Should it be inactivated by low pH?Actahttps://www.blogger.com/profile/11839870636321538119noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-26006847929542682642017-01-17T15:41:53.195+01:002017-01-17T15:41:53.195+01:00We spent many years developing (and testing) Avmac...We spent many years developing (and testing) Avmacol formulations that would consistently deliver both glucoraphanin (the sulforaphane precursor) and an active myrosinase enzyme. It is important to store the product in a cool and dry environment.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-8852519973328440862017-01-08T05:47:35.337+01:002017-01-08T05:47:35.337+01:00Hi
I am interestes in knowing what is the special ...Hi<br />I am interestes in knowing what is the special in Avmacol.<br />How it stabilize the active compounds?<br />Please explain. Thanks!Anonymoushttps://www.blogger.com/profile/09206059454215812199noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-45547031546983341172015-12-23T15:34:49.207+01:002015-12-23T15:34:49.207+01:00I helped to develop Avmacol, one of the products r...I helped to develop Avmacol, one of the products referenced in a prior October posting. I was lucky enough to be part of a fantastic research team that carried out clinical studies investigating the chemopreventive efficacy of sulforaphane (Carcinogenesis. 2007 Jul;28(7):1485-90). I have spent more than a decade researching this wonderful compound and can gladly put together a WebEx for those interested. I can share a bit of background and then open it up to Q&A. (Peter - if you get a chance to read this please let me know how I can contact you).Briannoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-13224040700371245142015-10-26T16:12:09.925+01:002015-10-26T16:12:09.925+01:00Hellow this is for all who read about brocoli spro...Hellow this is for all who read about brocoli sproud.I have buy by mistake 2 of supersprouts.If somebody is thinking to buy it and live in Europe,i can sell one.If someone is interested please write to:vicencomgi@hotmail.com.Thanks Peter and excuse me for posting here but I don,t know what to do with too much broccoli.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-34963065327905786412015-10-25T22:42:15.782+01:002015-10-25T22:42:15.782+01:00Some people do really benefit from the sulforaphan...Some people do really benefit from the sulforaphane produced by some broccoli powder. The problem is that most powders tested actually do not produce sulforaphane. The powders that do seem to work produce a mood improvement. It is well worth having, but it really is not the same as the famous "fever effect". It is clear that nobody has figured out what is behind this effect, lots of ideas but just that.<br /><br />One powder that does work is from Australia and is called Supersprouts, just google it. They ship everywhere. The dose is only half a teaspoon a day. In the people who respond there is a profound effect in about 30 minutes from the first dose.<br /><br />It is worth a try and may indeed help, but it does not match the fever effect.<br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-20580643395589733082015-10-25T21:15:32.101+01:002015-10-25T21:15:32.101+01:00I just bought some brocco max from Amazon and I...I just bought some brocco max from Amazon and I'm wondering if I should get something different at this point. I bought it because my HFA daughter shed her autism symptoms (what she describes as constant videos in her head) when she has a low grade fever due to a cold this past week. It was amazing so I researched remedies to mimic a fever and found this. I want to made sure I give her the right thing and I see lots of different information here. So my question is, what exactly do you recommend and where can I purchase it?<br />Thank you!!<br />Momofthreehttps://www.blogger.com/profile/17242501779063005254noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-77628254912104319182015-10-14T22:07:46.430+02:002015-10-14T22:07:46.430+02:00I bought online Swansons Daikon Radish powder, but...I bought online Swansons Daikon Radish powder, but never needed to use it. You would only need a tiny amount, much less than a capsule, but I do not think too much would do any harm. This is heat stable and can even be frozen. Good luck.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-10131532327500432272015-10-14T21:21:25.499+02:002015-10-14T21:21:25.499+02:00I'm thinking what if I used daikon radish powd...I'm thinking what if I used daikon radish powder to mix with whatever I end up choosing to buy? Is there any radish powder available online you would recommend? I might just und up purchasing and trying both the supersprout and Crucera-SGS separately along with the daikon radish root powder. If that still doesn't work than I guess I'm just one of those non responders to sulforphane. Do you buy daikon root powder and just mix it with the broccoli powder or take them as capsules? I can't seem to find a good source of it looking through supplant stores, only in capsules which I am not sure are effective either.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-3527575817688334572015-10-14T12:35:27.809+02:002015-10-14T12:35:27.809+02:00Bumetanide seems to have helped with spatial issue...Bumetanide seems to have helped with spatial issues with regards to writing. Also, my daughter was standing on one side of a bookcase and was looking for her headphones. I pointed to the case from the other side where she could not see me fully. So, she bent down, stuck her head close to one of the open sections and looked at my finger to see where it was pointing and then got her case. She has never been able to do this before. <br /><br />RGnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-24931999405596758882015-10-14T11:37:58.316+02:002015-10-14T11:37:58.316+02:00It would be great if someone tested all these prod...It would be great if someone tested all these products. A while back when someone did just that, they found that most produced no Sulforaphane. Then you are left wondering is it that the powder was not effective, (no Sulforaphane) or the powder worked but the Sulforaphane had no effect on that person.<br /><br />I choose Supersprouts because they seem to be somewhat in control of the production process (the powder does not come in big sacks from China) and it was not so expensive. They do not say how much Sulforaphane is produced and, even if they did, you have no way of knowing whether it is true.<br /><br />Enduracell is not a cheap product and I expect it will produce Sulforaphane, so perhaps it is a case that you are just not a responder. Not everyone is. From the same jar of Supersprouts, some people with ASD responded and others did not.<br /><br />I would save your money and try something totally new.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-33488367852571466412015-10-14T11:34:05.203+02:002015-10-14T11:34:05.203+02:00This comment has been removed by the author.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-79373730183184081292015-10-14T10:29:32.385+02:002015-10-14T10:29:32.385+02:00Hey there Peter,
So I've been doing some rese...Hey there Peter,<br /><br />So I've been doing some research to try and determine which broccoli sprout powder is effective so I can give it another try. I've tried Cell-Logic Enduracell but have not noticed any real changes. I was just about to order some SuperSprout (the one you give your son) when I happened to read the John Hopkin's article again and realized something in the last paragraph:<br /><br />"U.S. patent applications have been filed by The Johns Hopkins University for inventors Smith, Talalay and Zimmerman. Talalay and Zimmerman have divested themselves from all potential financial benefits. The sulforaphane-rich broccoli sprout extract is not a commercial product. Broccoli sprouts and seeds rich in glucosinolates have been licensed by Johns Hopkins to Brassica Protection Products LLC"<br /><br />So I went to brassica's website and under products, it took me to trubroc's website, and they only sell a variety of teas but there is a list of a few different products that contain at least some amount of trubroc (which is GLUCORAPHANIN, which once consumed apparently meets intestinal microflora and is converted to sulforaphane). Now I am not as educated on this topic as you, so maybe you can give me some insight on this whole situation.<br /><br /><br />So of the 8 or so products, 2 of them caught my attention because they had the highest content of this ingredient and are broccoli based. They are:<br /><br />1-Avmacol® 60 Tablets (containing 350 mg broccoli extract blend containing 25mg of glucoraphanin)<br /><br />2-Crucera-SGS (containing Sulforaphane Glucosinolate (from Broccoli extract (seed) (Brassica oleracea italica)) 50mg )<br /><br /><br />So my question to you is, would these supplements be of higher quality and effectiveness than, say, SuperSprout or Enduracell? The only reason they caught my attention is because of the indirect association to John Hopkin's product used during their research. SuperSprout doesn't give any real numbers or percentages of ingredients and Enduracell claims 1000mg of pure broccoli sprout powder yielding sulforphane.<br /><br /><br />I am somewhat overwhelmed with the conflicting information and my budget is pretty tight so I don't want to get an ineffective product, but I have read so many health benefits of sulforphane and how effective it is for some individuals on the spectrum. I am just curious to hear your thoughts/opinion on all of this since I'm a big supporter of your research and findings. Baclofen, NAC and Bumetanide have made big differences for me and I'm hoping this may be yet another piece to my puzzle. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-6234079913011112302015-08-19T17:50:33.233+02:002015-08-19T17:50:33.233+02:00That may be too specific question, since people do...That may be too specific question, since people do seem to get different benefits from the same drug. To improve cognition you could try piracetam, which some people respond very well to. There are other related nootropics.<br /><br />In my son the cognitive benefit is from Bumetanide, Atorvastatin and now cinnamon. There may be a response to PAK1 inhibitor BIO30 propolis, and at least one reader notes a positive response.<br /><br />Processing speed may be slow because he is not 100% "present", this might be rectified by bumetanide. Well worth a try. Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-35080093985387723962015-08-19T00:59:45.867+02:002015-08-19T00:59:45.867+02:00Peter, Your blog is terrific and much appreciated....Peter, Your blog is terrific and much appreciated. This might be too concrete a question: You often mention cognitive gains globally -- but the areas my child is hardest hit is processing speed and spatial issues. In your research, have you come across specific studies, drugs, or therapies, etc that particularly helped those areas specifically? I hope that is clear? thank you again! Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-53654685277951679492015-08-17T21:46:56.696+02:002015-08-17T21:46:56.696+02:00If your son can swallow capsules you can put the s...If your son can swallow capsules you can put the supersprouts powder in gelatin capsules, they do also sell it in capsules.<br /><br />There is no way to know which products produce SFN because, as with all supplements, they are not made with the quality controls and testings that is required by law from drug firms. The independent testing showed that most products produced no SFN, regardless of what was claimed.<br /><br />Great that you have found a helpful autism doctor.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-64656171551094202362015-08-17T12:47:48.940+02:002015-08-17T12:47:48.940+02:00Neurobiologix have released a capsule claimed to c...Neurobiologix have released a capsule claimed to contain 60mg sulforaphane glucosinolate. That would appear to be a strong claim in respect of the active ingredient itself. But, I'm a little cautious about claims re sulforaphane. Whats the best question(s) to ask them? We've tried super sprouts but couldn't get the boy to take it for a long enough trial period, so I'm trying to find a capsule (and apparently, the neurobiologix formula is quite as strong tasting for those who can't take a capsule).<br /><br />Cheers Peter.<br /><br />By the way, we've just got back from a US visit with a US MAPPS/DAN doctor who is very much into off-label/second indication use of existing drugs, particularly regarding GABA and NMDAr management, etc. Much more encouragingPiggin1972https://www.blogger.com/profile/17287586162516182485noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-3484829384591879642015-08-16T11:45:13.078+02:002015-08-16T11:45:13.078+02:00Readers seem to represent a wide range of ages. T...Readers seem to represent a wide range of ages. Three is young since most people are not diagnosed before then.<br /><br />Bumetanide and Sulforaphane (SFN) are different. SFN really does affect mood almost immediately. Bumetanide primarily affects cognition, and so once the brain starts to work better many other things also change.<br /><br />Bumetanide is used in babies. One reader gave it to his 3 year old until the age of 5, at which point the diuresis became a problem, since the child was still not toilet trained.<br /><br />SFN has only recently been suggested for use in autism. The dose is small and it really is just like eating a small plate of broccoli sprouts each day.<br /><br />I would recommend trying both, but first one (see if it works) and then the other. You will know within a few hours in SFN is effective. Bumetanide may take a month or two to take effect, but it was about 10 days for us. Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.com