tag:blogger.com,1999:blog-655962722302095847.post6331299275432672249..comments2024-03-27T20:20:54.505+01:00Comments on Epiphany: Epilepsy, Autism & EEGsPeter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-655962722302095847.post-40196622872199521382016-08-27T20:46:36.970+02:002016-08-27T20:46:36.970+02:00Hi Angeiszka,
Sorry I think I overlooked..
your ...Hi Angeiszka,<br /><br />Sorry I think I overlooked..<br /><br />your son's EEG readings also showed a pattern similar to the girl following bumetanide use. And he did improve cognitively.<br /><br />As far as spikes in EEG readings recorded during sleep, even your medical community is devided if minor aberrations, so common in autistic kids, is indicative of a higher probability of developing seizures in future<br /> <br /><br />Thank you so much for your response and as always best wishes for your son.Anonymoushttps://www.blogger.com/profile/03480846227414561711noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-51274289293221009182016-08-27T20:24:56.935+02:002016-08-27T20:24:56.935+02:00Hi Angeiszka,
Yes, I had gone through the Netherl...Hi Angeiszka,<br /><br />Yes, I had gone through the Netherlands case study. If I remember correctly, bumetanide was not able to alter seizure frequency in the girl although remarkable improvements in mental development were observed.<br /><br />As you explained, a reduction in alpha power of EEG reading would be indicative of a less diseased and better developed brain.<br /><br />And yes, epileptic individuals were not included on the French study.<br /><br />Thanks for interpreting the heavy EEG terminology. <br /><br /><br /><br />Anonymoushttps://www.blogger.com/profile/03480846227414561711noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-91573867004404676612016-08-27T17:53:14.079+02:002016-08-27T17:53:14.079+02:00I've encountered a problem to post a comment, ...I've encountered a problem to post a comment, so maybe you need to delete the previous one.<br /><br />There's a case report about a girl treated with Bumetanide in the Netherlands:<br /><br />"The treatment resulted in a marked clinical improvement in sensory behaviors, rigidity, and memory performance, which was substantiated by questionnaires and cognitive assessments. At baseline, the girl’s EEG showed a depression in absolute alfa power, an electrographic sign previously related to ASD, which was normalized with bumetanide treatment".<br /><br />http://pediatrics.aappublications.org/content/136/2/e539<br /><br />To some degree it is similar to what I saw in my son's EEG early on Bumetanide. It relates to awake EEG and translaing this 'dark art' to something more understandable to myself it means: less encephalopathic and less immature.<br /><br />Bumetanide did not reduce his epileptiform discharges on sleep EEG (which is a common pattern in autism), at least in first few weeks of treatment. We just came back from EEG yesterday, so I can post some new data soon.<br /><br />I might be mistaken, but I recall children in French Bumetanide study had EEG done before the trial and these with epilepsy were not included. So this group probably could not explain much about Bumetanide influence on epileptiform EEG.Agnieszka Wroczyńskahttps://www.blogger.com/profile/04738535364585304041noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-61376937224678163982016-08-27T12:21:05.734+02:002016-08-27T12:21:05.734+02:00Hello Peter,
Yes, few case studies as well as res...Hello Peter,<br /><br />Yes, few case studies as well as research articles are there on effect of bumetanide on EEG readings. However, some seem inconclusive, some even contradictory, and although bumetanide could prevent seizure activities in certain kinds of epilepsies, its much touted use as an anti epileptic drug in neo nates was also up for question.<br /><br />The learning center I take my son to is also visited by a paed-gynae couple with a severely affected, profoundly delayed son suffering from seizures. I just thought if i can lay my hands on something solid I could discuss it with them although they seem very uptight and probably mighy have already tried out all these interventions without any productive outcome.Anonymoushttps://www.blogger.com/profile/03480846227414561711noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-67034060764380147572016-08-27T06:55:05.735+02:002016-08-27T06:55:05.735+02:00Hi Peter,
Actually I was searching on the net for...Hi Peter,<br /><br />Actually I was searching on the net for parental reports on changes in EEG readings, a before and after sort of thing, following bumetanide use. I am sure some parent readers of this blog must have recorded these observations. Do you recall any mention of this.<br /><br />Thanks<br /><br />Anonymoushttps://www.blogger.com/profile/03480846227414561711noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-25279032429260712302016-08-26T23:07:30.754+02:002016-08-26T23:07:30.754+02:00This comment has been removed by the author.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-31856563283913882842016-08-26T22:20:22.309+02:002016-08-26T22:20:22.309+02:00That is a good question, but best directed to the ...That is a good question, but best directed to the researchers who are developing bumetanide as an approved drug. Their website is www.neurochlore.frPeter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-83752272603724858252016-08-26T20:02:21.918+02:002016-08-26T20:02:21.918+02:00Hello Peter,
I have a simple, probably naive quer...Hello Peter,<br /><br />I have a simple, probably naive query. Have changes in EEG been recorded following administration of bumetanide..from subclinical abnormalalities to a more normalised pattern.<br />Anonymousnoreply@blogger.com