tag:blogger.com,1999:blog-655962722302095847.post5500443735924290044..comments2024-03-27T20:20:54.505+01:00Comments on Epiphany: Home/Clinic based Photobiomodulation/Laser Therapy in Autism - acting on Light Sensitive Ion Channels, Mitochondria, Lymph Nodes and morePeter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger13125tag:blogger.com,1999:blog-655962722302095847.post-87261095562763981002019-08-11T04:23:43.545+02:002019-08-11T04:23:43.545+02:00Hi everyone, just thought I'd share these link...Hi everyone, just thought I'd share these links in case anyone was curious why research on electro therapies is still so new; Johnson & Johnson saw it as a threat to Tylenol sales and tried to kill it in the 70s. <br /><br /><br />https://ireliev.com/johnson-and-johnson-suppressed-electrotherapy-technology/<br /><br />https://www.nytimes.com/1981/08/26/business/johnson-johnson-fraud-suit.html<br /><br />https://law.justia.com/cases/federal/district-courts/FSupp/537/1282/2348374/Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-72945013405358820672019-07-11T23:46:23.354+02:002019-07-11T23:46:23.354+02:00Agnieska, you may or many not know, tDCS has many ...Agnieska, you may or many not know, tDCS has many different protocols, and whether you use anodal (potentiation), or cathodal (depotentiation), stimulation matters immensely in achieving the desired type of result for a particular brain area which by the way is only going to be on some part of the superficial areas of the lateral cortex. You can also sometimes stimulate the medial parts of the cortex by placing the electrodes on the midline of the scalp, but I have been rather skeptical of these methods. There has also been research with tDCS and rTMS where getting at subcortical brain structures indirectly by modulating cortical areas with strong connectivity has been successful, but I am a bit skeptical of these studies as well. The one I remember the best was for a potential Alzheimer's therapy in stimulating the hippocampus via rTMS over the superior parietal cortex.<br /><br />Also, I used to use 870nm infrared LED's on my son for about a year or two when he was younger after he would fall asleep and it seemed to work very well, but stopped doing the therapy when it became impractical because he started sleeping on his side. Also, the first 90 minute sequence of deep sleep in kids under age 12 (if I remember correctly) makes them extra unresponsive to sensory stimuli which can be useful when you are trying to do this therapy to a child who will not allow it when they are conscious.<br /><br />Also, I probably would of bought a laser in the past if not for the cost.<br /><br />I still use infrared LED's myself (not consistently anymore due to lack of time) for other reasons and have only had positive effects from them after many years of use now. It is becoming more mainstream has you now see several products with mainstream advertising for hair regrowth which are essentially arrays of LED's of 600nm red and 850nm infrared light arranged in a checkerboard pattern and then applied to some sort of hat or comb which gets under the hair allowing the light to directly hit the scalp.<br /><br />I know this discussion is about LLLT specifically, but I feel that if you take proper precautions (goggles if using lasers) and make sure you deliver the proper amount of Joules per centimeter squared, then there are no safety issues. As long as the user understands that more than the proper amount of stimulation will get less results or even negative results, I don't think safety is a problem.Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-52928420781102573402019-07-11T22:11:51.853+02:002019-07-11T22:11:51.853+02:00Agnieszka, I do not think that any of these therap...Agnieszka, I do not think that any of these therapies involving electricity, magnetism or light are really understood. I would not be the first to try one, but some have been around for many years and so there should be safety information. ECT (electro-convulsive therapy) looks the most wild and yet I read about a girl with severe autism and SIB, for whom ECT makes the SIB vanish for a few months until the next session of ECT at Johns Hopkins.<br /><br />You would think that ECT is not without risks.<br /><br />Is LLLT contraindicated in people with mast cell activation? You might assume that from that research paper, but I doubt that paper is the last word on the subject. So I would keep looking at LLLT until someone with MCAS tries it and has a negative experience.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-71551631863919421592019-07-10T23:27:25.031+02:002019-07-10T23:27:25.031+02:00Thank you Agnieszka, I think what you described fi...Thank you Agnieszka, I think what you described first in your post could be beneficial in my case, while not in yours!<br />I'm still curious at what interventions will work for both of us. <br /><br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-48273772599460186652019-07-10T01:45:43.862+02:002019-07-10T01:45:43.862+02:00It seems that caution is needed with some of the n...It seems that caution is needed with some of the neuromodulatory modalities. I've just learned that one type of tDCS - "anodal transcranial direct current stimulation" - might not be the best for those with gain of function type VGCC issues:<br /><br />"TDCS effects have been directly or indirectly associated with membrane depolarization-dependent increases in intracellular Ca2+ levels via NMDAR and voltage-gated calcium channel activation.".<br /><br />I am also curious about laser induced mast cell degranulation proposed as LLLT mechanism highlighted in this post. "released ATP and histamine may be putative mediators for therapeutic effects". <br />Does it mean that children with mast cell activation should rather avoid this kind of treatment?Agnieszka Wroczyńskahttps://www.blogger.com/profile/04738535364585304041noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-82347469896481865842019-07-08T18:39:49.478+02:002019-07-08T18:39:49.478+02:00Agnieszka, the various devices mainly developed fo...Agnieszka, the various devices mainly developed for epilepsy are summarised here.<br /><br />https://www.epilepsy.com/learn/treating-seizures-and-epilepsy/devices<br /><br />TNS has been studied at UCLA for ever ten years. It clearly does have an effect and the effect can be measured in a PET scan.<br /><br />So it will have an effect; is it going to help in one specific case? Nobody can tell you.<br /><br />I think it looks a bit hit and miss, but at UCLA they have shown some people do benefit. Since it is non-invasive it is not such a big step to take.<br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-33048648178760064352019-07-08T13:46:12.118+02:002019-07-08T13:46:12.118+02:00Brooke,
Just wonder if your son tried melatonin?...Brooke, <br /><br />Just wonder if your son tried melatonin? It has been suggested to be beneficial in GERD:<br />https://www.ncbi.nlm.nih.gov/pubmed/22180850<br /><br />"Does a melatonin supplement alter the course of gastro-esophageal reflux disease?"<br /><br />In my personal experience it is really helpful for this condition at the dose 3-5mg daily.<br /><br />And here is another paper on melatonin and GI issues, not directly relevant to GERD, but interesting:<br /><br />https://www.hindawi.com/journals/bmri/2018/2607679/?fbclid=IwAR1kFMArb1VAQ_TEMV9CUXnV6u2945ck5V-uaxT0nHMBtlB01v-Z6DL1IwU<br /><br />"Effects of Melatonin on Intestinal Microbiota and Oxidative Stress in Colitis Mice"Agnieszka Wroczyńskahttps://www.blogger.com/profile/04738535364585304041noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-69622275396396075732019-07-08T13:35:24.705+02:002019-07-08T13:35:24.705+02:00Peter,
I wonder what is your opinion on another ...Peter, <br /><br />I wonder what is your opinion on another non-pharmacological intervention: external Trigeminal Nerve Stimulation, which has been recently approved by FDA for ADHD:<br /><br />https://www.fda.gov/news-events/press-announcements/fda-permits-marketing-first-medical-device-treatment-adhd<br /><br />https://www.ncbi.nlm.nih.gov/pubmed/30768393<br />Double-Blind, Sham-Controlled, Pilot Study of Trigeminal Nerve Stimulation for Attention-Deficit/Hyperactivity Disorder.<br /><br />I am curious about this method as apparently it is also used in migraine prevention:<br />https://www.ncbi.nlm.nih.gov/pubmed/26467451<br /><br />It is the same method in general, but different device and I am not sure if the type of stimulation is similar. It is easily available where I live.Agnieszka Wroczyńskahttps://www.blogger.com/profile/04738535364585304041noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-32401182422408529402019-07-08T08:15:55.068+02:002019-07-08T08:15:55.068+02:00Brooke, Verapamil does help some's GI problems...Brooke, Verapamil does help some's GI problems and was used to treat IBS. I think there must be a trigger to your son's recurring GERD. Verapamil is a very safe drug so you could discuss it with your doctor.<br /><br />It is clear that some people metabolize bumetanide differently to others. In some people there is huge diuresis, while in others there is none. It is strange that your son only tolerates a small dose, but he is not the only one. If a small dose helps, I would just use that.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-49960723519446043052019-07-08T08:06:42.970+02:002019-07-08T08:06:42.970+02:00I doubt it will do any harm, you would have to try...I doubt it will do any harm, you would have to try it to see if it has a benefit. The cream is not cheap.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-86667555927397633892019-07-08T02:16:04.749+02:002019-07-08T02:16:04.749+02:00Hi Peter,
I wrote early this spring about Ketones ...Hi Peter,<br />I wrote early this spring about Ketones (which I never did) but described my son then as low verbal but using a letter board to attend university and doing pretty well. We've done lots of biomed through the years with good results and his doctor and I are using your blog to pursue other things and we appreciate your work.<br />I have two questions. First you said in one post to use Verapamil only if there was extreme anxiety and aggression and in the post on EoE you said it might help. My son has bad GERD symptoms that come and go and I've never been able to help it. Would you try Verapamil just for that? <br />And second question, we've been using Bumentatide since late Spring with good results but every time I go above .25mg in the am and afternoon we get excitability and I am surprised because he is 165 pounds and it seems he could tolerate more. Do you have any thoughts?<br />Thanks!Brooke P.https://www.blogger.com/profile/11686799908165163703noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-55360456911725962302019-07-07T18:16:36.299+02:002019-07-07T18:16:36.299+02:00Peter,
What do you think about the sophia flow c...Peter, <br /><br />What do you think about the sophia flow cream and lymphatic massage nightly would you try it <br /><br />ThanksAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-20709923142261305732019-07-06T07:34:42.428+02:002019-07-06T07:34:42.428+02:00How would you constrict lymphatic flow without cau...How would you constrict lymphatic flow without causing something like midodrine induced catatonia? I think this would definitely be a poly pill solution at least right now. I but meet pots symptoms but won't get diagnosed with anything more than a verbal "oh well you clearly have dysautonomia, but...."<br /><br />I'm also curious if ketitofen might affect the light therapy. I notice it modulates the pain I feel in response to light.Anonymousnoreply@blogger.com