tag:blogger.com,1999:blog-655962722302095847.post4819564342752178833..comments2024-03-27T20:20:54.505+01:00Comments on Epiphany: Ketones and Autism Part 2 - Ketones as a Brain Fuel to treat Alzheimer’s, GLUT1 Deficiency and perhaps morePeter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger31125tag:blogger.com,1999:blog-655962722302095847.post-46060436583843325862018-08-18T16:36:10.989+02:002018-08-18T16:36:10.989+02:00Google "iherb C8 oil" or "amazon C8...Google "iherb C8 oil" or "amazon C8 oil"<br /><br />It is not cheap but 1000ml would last quite a long time.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-24967815006109779732018-08-18T16:05:49.394+02:002018-08-18T16:05:49.394+02:00Where can I buy it in a bottle, seems more handy t...Where can I buy it in a bottle, seems more handy too than popping yet another more pills, used google and all I could find is MCT oil, which isnt pure c8 oil.<br /><br />With regards to the cholesterol effects im not too worried, cardio and coq10 keep that in check. Also the study I have seen on coconutoil, caused a mild elevation in ldl and a pretty good improvement in hdl, while a diet consistent of mostly oliveoil lowered ldl and didnt do anything for hdl.<br />I take both in my diet anyway.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-79040241071788140702018-08-18T12:18:48.989+02:002018-08-18T12:18:48.989+02:00Aspie1983, C8 (caprylic acid) is interesting to tr...Aspie1983, C8 (caprylic acid) is interesting to try, but the amount in those capsules is tiny. You can also buy it in 500ml or 1000ml bottles and take it in 10-20ml doses.<br /><br />Coconut oil contains only about 6% C8, it has several other constituents.<br /><br />Coconut oil does do some clever things, not yet understood. US cardiologists say it is very unhealthy because it should increase "bad" cholesterol, but in a small trial in humans it did the opposite.<br /><br />C8 has several different modes of action that may be helpful to some people, but coconut oil will have even more effects, since it contains much more than just C8.<br /><br />If you want to produce BHB, best to take C8 by the tablespoon rather than coconut oil by the tablespoon.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-43666185889408754872018-08-17T19:53:43.736+02:002018-08-17T19:53:43.736+02:00Peter, im a responder to coconutoil it seems very ...Peter, im a responder to coconutoil it seems very good for mental clarity and prevents social communication induced fatigue so to speak (socializing too long takes a toll on my brain, ie. headaches, boredom and possibly inflammation I reckon) this is greatly improved by psilocybin it seems, took my 2nd microdose yesterday on it and still going strong.<br /><br />However every time I eat a meal and I add a heaping tablespoon (~15grams) of coconutoil I seem to have plenty of brain energy. You mention Tricaprylin, is this the same as regular caprylic acid such as in this product?<br /><br />https://nl.iherb.com/pr/Solaray-Capryl-Sustained-Release-100-Veggie-Caps/18964<br /><br />Caprylic acid is used in candida aswell from what I have read, which is also a reason why Ive been upping my coconutoil intake.<br /><br />The white plaques at my tongue started when I was really sick last winter, had to puke like mad a few times, oddly this ilness happened when I was taking ACV (apple cider vinegar, which is a source of acetate). I felt a couple of times as if I burned a hole in my stomach while being sick, I wonder if ACV screwed up my intestinal barrier or something.<br /><br />This happened a few weeks after I discontinued memantine and I was taking piracetam aswell (which according to studies is immunosupressive). I feel as if the immunosupression by piracetam is the same reason I felt so good on it though, it was as if my body was leaving my brain alone and I could do mentally what I want.<br /><br />Caprylic acid seems kind of cheap, also would you say since Im a responder to coconutoil that I would be a responder to stuff such as BHB/keto diet?<br /><br />Thanks allready.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-36312208691630722432018-07-25T09:54:57.484+02:002018-07-25T09:54:57.484+02:00D&G, the authors of the paper suggest that ele...D&G, the authors of the paper suggest that elevated BHB and lactate post-glucose indicates mitochondrial disease. There are good reasons why some people with mitochondrial disease might respond well the ketogenic diet, or just ketone supplementation.<br /><br />Some people with ASD do seem to respond well to a glycemic diet, as used by people with type-1 diabetes who want to minimize carbohydrate intake and so reduce their injected insulin requirement.<br /><br />In your case you might just need to avoid swings in blood sugar through diet. You could try ketone supplements, you could increase insulin sensitivity to reduce swings in blood sugar, like people with type-2 diabetes.<br /><br />You can increase insulin sensitivity using many things thought of as antioxidants (Alpha lipoic acid, beetroot, cinnamon, cocoa flavanols etc). There are also many long established drugs, some of which are used in autism (PPAR gamma agonists)<br /><br />I would ask your doctor to check for reduced insulin sensitivity. There are tests, but I am not sure how widely used they are.<br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-91613256471857870522018-07-25T08:55:01.478+02:002018-07-25T08:55:01.478+02:00Never did the tablets because they were cost prohi...Never did the tablets because they were cost prohibitive unless you only did one per child per day since each tablet is roughly a dollar a day. If I was rich I could afford to spend 20 dollars a day on tablets, but since I am not, I opted with the more time consuming method of increasing the Biogaia yield.Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-10161382668490835412018-07-24T22:44:28.394+02:002018-07-24T22:44:28.394+02:00Thanks, managed to find it, will be doing your rec...Thanks, managed to find it, will be doing your recipy soon now :).<br /><br />How did you find your kids responded to the tablets itself vs the homemade biogaia kefir? Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-13955991100439809542018-07-24T22:32:11.002+02:002018-07-24T22:32:11.002+02:00Extremely good find Tyler, I have been on agmatine...Extremely good find Tyler, I have been on agmatine now a while with dosing between 750-1250mg. I do notice its vasodilating effects are real and just as strong as citrulline.<br /><br />With regards to mood/wellbeing/emotions, it does seem to make me more layed back in general and it seems to help with depression a bit too, however I do not find it has a lot of emotional benefits. Keep in mind I am indeed using some other stuff through, what I do notice (and this happens pretty much every time with agmatine when I take it by itself) is the insane amount of yawning even in the morning and I normally never yawn in the morning, I reckon this oxytocin/dopamine mediated, they are known to induce yawning so it surely must be doing something. I mean... how could placebo possibly make me yawn when I normally literally never ever yawn.<br /><br />Interesting also in this study is the chronic agamtine dosing that they done, the bloodpressure was a fair bit lower aswell in agmatine rats vs none agamatine fed rats of same age.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-53154555319257370632018-07-24T19:52:48.602+02:002018-07-24T19:52:48.602+02:00I reposted the recipe directly to you a few pages ...I reposted the recipe directly to you a few pages back (not sure where). Try a Google search for what you are looking for prefixing with "site:epiphanyasd.blogspot.com" so you only get Epiphany posts you are searching for.Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-31171554405558500322018-07-24T19:51:11.197+02:002018-07-24T19:51:11.197+02:00Another interesting bit of research popped up with...Another interesting bit of research popped up with regards to eNOS functionality in the brain:<br /><br />Press Release:<br /><br />https://www.sciencedaily.com/releases/2018/07/180723143007.htm<br /><br />Paper:<br /><br />http://www.pnas.org/content/115/29/E6900<br /><br />To summarize things, these researchers were investigating a large type of neuron in the most primitive part of the brain stem called nucleus gigantocellularis neurons or NGC neurons for short. These neurons are unique in that they can synthesize eNOS not just for their own use in increasing blood flow to themselves, but also apparently to increase arousal in many other areas of the brain, especially the thalamus which is critical to maintaining consciousness.<br /><br />Agmatine of course raises eNOS levels in the brain (here is one of many studies showing this feature, this one dealing with cognitive decline from aging):<br /><br />https://www.tandfonline.com/doi/abs/10.1080/24750573.2017.1309090<br /><br />The interesting thing here is that possible dysfunction of these neurons could have wide-ranging effects on consciousness and cognition, even though they are located in a very primitive part of the brain (evolutionarily speaking). Perhaps, one benefit of agmatine at the right dosage might be to raise eNOS levels throughout the brain to compensate for any problems with these types of neurons. There are no studies I have seen that show irregularities with NGC neurons in autism (I don't even know if they have been studied with respect to autism), though there are other brain stem nuclei that have shown irregularities such as the infefior olive.Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-92091684709437247192018-07-24T18:49:20.633+02:002018-07-24T18:49:20.633+02:00Thanks Peter, I might have not put it correctly bu...Thanks Peter, I might have not put it correctly but I kinda meant that the brain recognizes that its losing water, this apparently can cause 5ht2c receptors to upregulate.<br /><br />Oxytocin and vasopressin release by dehydration is partially due to 5ht2c activation.<br />SSRI's downregulate this receptor, along with 5ht2a and 5ht1a.<br /><br />I got psilocybin coming in tomorrow, I will try it again, my first attempt over a year ago was very good, however im very scared to downregulate my 5ht2a receptors (these are low in aspergers, hence my anger towards my psych feeding me years long of ssri's).Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-70979998193424789852018-07-24T15:47:47.205+02:002018-07-24T15:47:47.205+02:00Aspie, Bumetanide should not cause dehydration, it...Aspie, Bumetanide should not cause dehydration, it certainly causes diuresis, but then you increase your fluid intake to fully compensate. The net result should be no dehydration, but expect to drink 3 liters of water a day. Within reason, you cannot overdo it. <br /><br />Often bumetanide is prescribed to overweight older people who have too much fluid in their system and have high blood pressure. Reducing fluids in their bodies lowers their blood pressure. <br /><br /><br /> Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-3997930513250260422018-07-24T13:10:19.644+02:002018-07-24T13:10:19.644+02:00@Peter and @Nancy, you say it costs $40, I want to...@Peter and @Nancy, you say it costs $40, I want to try it.<br /><br />Nancy could you help tell me how you done it? I want to give it a try, Ive been hesitant to try the bumetanide I have at home.<br /><br />Also @Peter, since bumetanide basically puts one in a mild state of dehydration (atleast I think?), what are you thoughts about bumetanide possibly affecting 5ht2c serotonin receptor, this one is upregulated with thirst/dehydration and help release oxytocin and vasopressin.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-12475066414032964522018-07-24T12:35:18.574+02:002018-07-24T12:35:18.574+02:00Hi Peter,
With respect to a study you've refe...Hi Peter,<br /><br />With respect to a study you've referenced in a prior post - see link below - a ketogenic diet was instituted in patients who had demonstrated a pathological increase in serum β-hydroxybutyric acid associated with glucose loading. In 1 of the 6 patients showed a 'remarkable' improvement while the remaining 5 were more subtle.<br /><br />What are your thoughts on the 'glucose loading' test? Also your thoughts on table 3 that captures pre and post β-hydroxybutyric acid values after glucose loading test. These values are used as a marker for pathology and hence could predict favourable candidates for ketogenic diet.<br /><br />https://www.researchgate.net/publication/259628057_Evidence_for_Treatable_Inborn_Errors_of_Metabolism_in_a_Cohort_of_187_Greek_Patients_with_Autism_Spectrum_Disorder_ASD<br /><br />I'd like our child to undergo the loading test as consumption of 'any' source of carbohydrates renders marked deterioration in all behaviours and functioning. Conversely, behaviour and all else is 'remarkably' better on an empty stomach.<br /><br />Thanks Peter,<br /><br />Regards,<br />D&GAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-32058042198033141932018-07-24T11:04:10.934+02:002018-07-24T11:04:10.934+02:00Aspie1983, Bioelectronic Medicine is an emerging f...Aspie1983, Bioelectronic Medicine is an emerging field where drugs are not used, instead tiny electric signals are used to target a specific nerve to achieve a similar, or better, effect than a drug.<br /><br />There is big money going into this field, but it is not simple. The Vagus Nerve contains 1,000s of individual fibers rather than it being like a single electrical cable. Current technology is crude and stimulates all of them. Future technology aims to target just specific parts for a very specific purpose.<br /><br />It is amazing to me that today's crude VGS has any benefits, but in arthritis it clearly does. <br /><br />Nancy is stimulating the vagus nerve by the branch that goes to the left ear. Again it is surprising that this can have an anti-inflammatory effect, but trials show it does.<br /><br />In future years the implanted devices are going to be tiny and ultimately will target specific signals carried in this nerve and not interfere with all of them. <br /><br />I don't think there is a guide to do it yourself VGS.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-24341281196034041832018-07-23T20:16:57.169+02:002018-07-23T20:16:57.169+02:00@Tyler,
I lost the post you made on how to make t...@Tyler,<br /><br />I lost the post you made on how to make the reuteri yoghurt, could you link to the post (if you remember it) and give me a shopping list of exactly what I need to buy for it. Im such a rookie at this, Ive been delaying making the yoghurt and now I lost your post :/Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-30140082308226689282018-07-23T20:15:33.833+02:002018-07-23T20:15:33.833+02:00Peter, regarding these vagus nerve stimulators you...Peter, regarding these vagus nerve stimulators you talk about, could you do a guide/article on what to buy/how to applie and what to expect of it?<br /><br />Im having a hard time understanding it all, also how effective is Transcranial magnetic stimulation and what are the odds if I want to sign up to get myself treated for this that ill get it?<br /><br />Im lost in a maze when it comes to stuff like this.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-15259675666334839502018-07-23T19:00:18.702+02:002018-07-23T19:00:18.702+02:00Tyler, that is interesting and is another angle at...Tyler, that is interesting and is another angle at the same problem that Vagus Nerve Stimulations is now being applied to in real life in the US and indeed the UK.<br /><br />https://www.sciencedaily.com/releases/2018/03/180327162606.htm<br /><br />Given that Nancy has enlightened us that you can indeed stimulate the vagus nerve therapeutically for kit costing $40 on Amazon (TENS unit plus electrodes for the left ear) the day is not far away when therapists give an acetylcholine burst to help learners retain new motor skills.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-63765237581133303722018-07-23T18:22:57.998+02:002018-07-23T18:22:57.998+02:00For those looking at improving motor skills in tho...For those looking at improving motor skills in those with autism, here is some interesting research that suggests motor skills are better consolidated to long-term memory if 15 minutes of exercise follows:<br /><br />Press Release:<br /><br />https://www.sciencedaily.com/releases/2018/07/180711153607.htm<br /><br />Paper:<br /><br />https://www.sciencedirect.com/science/article/pii/S1053811918302398?via%3Dihub<br /><br />My oldest child with the most motor challenges strangely has good balance, but is not great with visuo-motor skills like catching a ball and though he is improving with handwriting, it is nothing even remotely close to grade level. He also can't tie his shoes, among many other things, and the things he can do he can be quite clumsy at, so this research is interesting from that perspective since making motor learning stick seems to be a problem he has had from the beginning as his crawling and walking were also delayed as a baby.Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-38602302333158696142018-07-22T05:51:56.446+02:002018-07-22T05:51:56.446+02:00Hi Aspie,
I don't know much at all about Azos...Hi Aspie,<br /><br />I don't know much at all about Azosemide, just what was in the paper. When I looked for where it was available, it was pretty much only in Asia as Peter has just noted. As per the trade names in the following link, there are only trade names in Asian countries:<br /><br />https://www.drugs.com/international/azosemide.html<br /><br /><br />If, as Peter said, it also blocks Kcc2, that would limit its usefulness, but if it doesn't, and if it Bumetanide benefits ASD kids via the NKCC1 mechanism of action, one would think that Azosemide would be interesting to look at, especially as it seems to better cross the BBB than Bumetanide. <br /><br />Have a great day!<br /><br />AJ<br /> Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-54831319963389910212018-07-21T21:07:14.371+02:002018-07-21T21:07:14.371+02:00Azosemide seems to be mainly used in Japan and Chi...Azosemide seems to be mainly used in Japan and China. Studies shows side effects are similar to other loop diuretics. It looks like it is not used in Germany, where it was developed.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-68823477058519973242018-07-21T19:44:47.927+02:002018-07-21T19:44:47.927+02:00AJ, what about its side effect profile, the wiki p...AJ, what about its side effect profile, the wiki page on Azosemide is basically empty.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-82288399307303034232018-07-21T19:39:48.151+02:002018-07-21T19:39:48.151+02:00Oh right that makes a lot more simple to understan...Oh right that makes a lot more simple to understand.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-83010768908810042172018-07-21T19:03:46.428+02:002018-07-21T19:03:46.428+02:00Aspie1983, chloride enters neurons via NKCC1 and e...Aspie1983, chloride enters neurons via NKCC1 and exits via KCC2. If you have too much chloride in neurons you want to block NKCC1 and/or open KCC2.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-17309704989461542732018-07-21T18:11:43.147+02:002018-07-21T18:11:43.147+02:00AJ, that is very interesting. Azosemide is widely ...AJ, that is very interesting. Azosemide is widely available.<br /><br />The only question is what is does to KCC2 that lets chloride out of cells. Furosemide blocks NKCC1 but also blocks KCC2, which is why it is no good for autism. Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.com