tag:blogger.com,1999:blog-655962722302095847.post4544176483785285375..comments2024-03-28T22:33:35.806+01:00Comments on Epiphany: Clonidine, ADHD and AutismPeter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger11125tag:blogger.com,1999:blog-655962722302095847.post-58535212378208295742021-12-31T01:58:20.858+01:002021-12-31T01:58:20.858+01:00Really interesting about the Clonidine. In my son&...Really interesting about the Clonidine. In my son's case, I believe he has too many catecholamines with nowhere to go, as supported by labs we've done. His MAO-A status is T, which means perhaps not enough degrading activity. Do you know of any substances that would increase MAO-A? I guess Clonidine is worth trying in his case. I'm a MAO-A TT myself and have Clonidine prescribed for the emotional dysregulation of ADHD. I haven't noticed any effects but perhaps have not been taking it long enough, or high enough dose. Susannoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-75859367495006619622019-12-19T15:54:41.335+01:002019-12-19T15:54:41.335+01:00Hi Peter
I ask our doctor about Mirtazapine and sh...Hi Peter<br />I ask our doctor about Mirtazapine and she is not willing to try it. For constipation she give her oral lactulose. Constipation dose improve at high dose as her autistic symptoms. I really think that lactulose has positive effect on her autism. Do you think would be possible?<br />We try again NAC without any effect (the third time). We tried also carnitine supplement without any effect. Two weeks ago we gave a try to levocarnitine (carnitor), this time with an effect. We saw after a few days positive effect on constipation even without lactulose, but after a week something strange happens. My daughter develop psychosis, she withdraws from the environment even gets aggressive and yield to herself calling her name repeatedly. Could have this state for hours. As a remedy we give her a product that contain (GABA 25mg, L-Theanine 25 mg and Glycine 12.5mg). With this product her aggression and psychosis were gone in less then ten minute. Since we stooped carnitor she went to her normal state. I thought that carnitine is also an antioxidant but in fact I read a study that say that carnitine can increase malondialdehyde that is a marker for oxidative stress. Do you think that my daughter reaction to carnitor can have an link with a predisposition for seizures? Thank you I have leaned a lot from your blog. <br /><br /><br /> <br />pradanoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-14080230472993590792019-11-19T20:51:36.291+01:002019-11-19T20:51:36.291+01:00Prada, clonidine seems to reduce anxiety in 85% of...Prada, clonidine seems to reduce anxiety in 85% of people but increase it in 15%. So increased anxiety is a known side effect.<br /><br />Your daughter's reaction probably does tell you something, but I am not sure how useful this will be regarding her autism.<br /><br />If you have a helpful doctor, you might ask about very low dose Mirtazapine. This is an old antidepressant derived from the original first generation antihistamines. It is used off-label in autism and also schizophrenia. It has several different effects. At 5mg, which is a 1/6 typical dose, it is very sedating, via H1 histamine receptors in the brain. A good night's sleep is almost guaranteed. This might help establish a new sleep pattern and then you could gradually reduce it to zero.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-82300899102215942042019-11-19T17:43:13.993+01:002019-11-19T17:43:13.993+01:00Hi Peter, I give a try to clonidine for sleeping p...Hi Peter, I give a try to clonidine for sleeping problem (difficult to fall in sleep) and did nothing after 3 weeks try at 0.5mg (my daughter is 7). Few days ago our doctor increased to 0.1 mg. At this dose she get very nervous, bite herself, very frustrate at bedtime even though it works this time for sleep (she fall in sleep in less then an hour). Could be that because of lowering too much the blood tension, or the tension in the brain? What are your thoughts about this reaction? Did has a link with a particularly sub-type of autism? Thank you for your generosity. pradanoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-89998851448813704012016-08-15T12:59:45.842+02:002016-08-15T12:59:45.842+02:00You need to ask your doctor specific questions abo...You need to ask your doctor specific questions about drugs and their interactions.<br /><br />Most standard drugs used in autism seem to frequently make things worse. Clonotril (Clonazepam) at the usual dose is addictive. <br /><br />Clonidine's benefit seems to be a mild sedative effect and there are better ways to achieve that, like centrally active H1 antihistamines,<br /><br />Baclofen appears to be the drug that helps most people with Asperger's, without negative effects or addiction. It looks like 5mg two or three times a day is a good place to start. This dose does not seem to help people with more severe autism. Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-5710723846648501062016-08-14T23:03:34.683+02:002016-08-14T23:03:34.683+02:00Hi Peter! My 14- year-old son, diagnosed with Asp...Hi Peter! My 14- year-old son, diagnosed with Asperger's and Tourette's, is coming off Risperdal. I started giving him Clonidine which seems to calm him a bit but he tics all the time!! It's soo sad to see him suffer so much. He is a total wreck! I HAVE TWO QUESTIONS: 1) How much clonidine should i give him? He weighs 82 kg and his blood pressure is normal. 2) Can he take clonotril as well (to relax his muscles) or the combination with clonidine could be dangerous? Of course, in case you have any suggestions to make this ''transition'' a bit easier, please share with me! Coming off risperdal seems to be so difficult....Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-82965077701157064442016-07-11T18:57:30.616+02:002016-07-11T18:57:30.616+02:00I also wanted to add that we use the long acting f...I also wanted to add that we use the long acting form of Clonidine during the day and then the regular form at night for sleep. My son's doc said this is fine. He is on the lowest dose. Anonymoushttps://www.blogger.com/profile/08928852677765675102noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-71727197866613602962016-07-11T17:37:39.233+02:002016-07-11T17:37:39.233+02:00Clonidine is the only pharmaceutical that has been...Clonidine is the only pharmaceutical that has been helpful for my son's hyperactivity and insomnia. We began using the regular form (pill) about 5 years ago to help him sleep. We had tried EVERYTHING to no avail. His doctor suggested we try Clonidine and we were amazed. We started wondering if a 1/2 a pill during the day would slow him down since he is ALWAYS on the move and extremely distracted. We didn't get the effect we were looking for. We then tried the long acting form and it has helped slow him down considerably. My son is 11 years old with Autism. No side effects that I have noticed. Unfortunately it doesn't help his anxiety (nothing does), but he seems to be more comfortable in his skin since he isn't in constant motion. Anonymoushttps://www.blogger.com/profile/08928852677765675102noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-65264509819947389302015-10-07T02:26:46.728+02:002015-10-07T02:26:46.728+02:00I have a 5 year old son with ASD. We give him Clo...I have a 5 year old son with ASD. We give him Clonidine to help manage his hyperactivity and agitation. When I say manage, I am NOT talking about just making him quiet down so Mom and Dad can watch a movie. I am talking about stopping property destruction, SIB, and aggression towards his little brother. We use it as needed. Basically, it just makes him really sleepy, so it's not really a solution. Think of it like a sedative. <br /><br />Also, the patch form falls off way before it's time to apply another one. It's not really designed for active kids that get sweaty. <br /><br />I hope this helps.JBhttps://www.blogger.com/profile/17769827238808423873noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-75702020047815732232015-10-06T08:37:57.473+02:002015-10-06T08:37:57.473+02:00I did not try it, but it does help some people wit...I did not try it, but it does help some people with ASD. If you can obtain it, a trial to see if it is effective in your specific case is the way to go.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-79191167059853483972015-10-06T06:03:05.004+02:002015-10-06T06:03:05.004+02:00Peter, did you try Clonidine for your son? Any fe...Peter, did you try Clonidine for your son? Any feedback from other parents? Readers?Anonymousnoreply@blogger.com