tag:blogger.com,1999:blog-655962722302095847.post4253127820826544112..comments2024-03-27T20:20:54.505+01:00Comments on Epiphany: Memantine – yet another failed Autism TrialPeter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger112125tag:blogger.com,1999:blog-655962722302095847.post-65862885334602058272023-01-25T17:16:01.340+01:002023-01-25T17:16:01.340+01:00It is very hard to know what dosage should one use...It is very hard to know what dosage should one use. I am seeing good things too but I am wandering about the dosage.<br />akhdanhttps://www.blogger.com/profile/03432115180247496632noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-86332859969199965572020-04-09T12:59:50.421+02:002020-04-09T12:59:50.421+02:00Maja, thank you for explaining about Rifaximin and...Maja, thank you for explaining about Rifaximin and Pentoxifylline.<br /><br />Good luck with Memantine. I tried it 2 years ago and the effect on speech was clear enough to get my son's assistant interest in autism treatment itself. Unfortunately I couldn't continue because of sleep issues, which is quite common adverse effect of several interventions in my son and really rare for Memanitne. I also started with low dose (2,5 mg) because of interaction with acetazolamide. <br />Agnieszka Wroczyńskahttps://www.blogger.com/profile/04738535364585304041noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-30688074805520568612020-04-08T09:43:51.221+02:002020-04-08T09:43:51.221+02:00Maja, it's always good to be cautious. With me...Maja, it's always good to be cautious. With memantine, I think you will get either a good effect or no effect. Even if your daughter has hypofunction of NMDArs, I doubt you will see a noticeable bad effect.<br /><br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-32162385915767588242020-04-08T09:36:16.394+02:002020-04-08T09:36:16.394+02:00Thank you for the links Peter, those figures are g...Thank you for the links Peter, those figures are good. It's odd that the mechanism is not known yet.<br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-45873991866299224762020-04-07T13:16:04.059+02:002020-04-07T13:16:04.059+02:00Dear Аgnieszka, Ling, and Peter,
I have been usin...Dear Аgnieszka, Ling, and Peter,<br /><br />I have been using Fisetin for some time, since I've heard for it from you, Ling. It makes her cheerful, stable. But her OCD wasn't affected by it. NAC didn't have that power, too. Magnesium has it, but for a very short time (an hour or two), and that's why I am thinking of Memantine...<br />Ibudilast is so interesting! It is surely on my wish list.<br /><br />Peter, Pentoxifylline (400 mg) hasn't got even one side effect at my trial. I tried it even in the dose of 800mg, with no problems at all. However, 400mg with Bumetanide is enough. It takes some time to show full effect, 2-3 weeks. On the other hand, if the Pentoxifylline is withdrawn, acne poop up fast (after only 2 days).<br /><br />Аgnieszka, Rifaximin made her prone to viral infections (not Pentoxifylline, which should be more reasonable). The same one that made her present at the start.<br /><br />Pentoxifylline may decrease the excretion rate of Memantine which could result in a higher serum level (from Drugbank). So, I am going slowly, with 2.5mg/day (started 3 days ago). It takes time to get to the 10, 15 mg/day of Memantine, or even more.<br /><br />Best wishes to all,<br />Maja<br />majadjhttps://www.blogger.com/profile/07148852308130407488noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-18149829289851686332020-04-06T23:47:04.711+02:002020-04-06T23:47:04.711+02:00Ling, the effect seems to be via IL-6 and/or IL-1b...Ling, the effect seems to be via IL-6 and/or IL-1b, but the exact mechanism seems not to be known.<br /><br />There is also the TRPV-1 receptor which affects KCC2 expression and is viewed as a brain inflammation detector.<br /><br />The first paper has a nice graphic to explain the role of IL-6<br /><br />Novel Treatment Targets Based on Insights in the Etiology of Depression: Role of IL-6 Trans-Signaling and Stress-Induced Elevation of Glutamate and ATP.<br />https://europepmc.org/article/pmc/pmc6789839<br /><br />The following paper is about the cytokines that are elevated in the Maternal Inflammation model of autism and affect NKCC1/KCC2. A role for mTOR is suggested.<br /><br /> https://www.biologicalpsychiatryjournal.com/article/S0006-3223(17)32053-X/pdf<br /><br />The transient increase in proinflammatory cytokines occurring in the fetal brain after MIA likely is at the root of the processes leading to KCC2 dysregulation. Indeed, normal expression of KCC2 in the offspring can be restored by genetic (IL-1RI KO) or pharmacological (MgSO4) approaches able to prevent the transient increase in IL-6 and IL-1b in the fetal brain. Although we are presently unable to selectively pinpoint which one of the two cytokines—which are potently cross-regulated—may be directly responsible for the defective excitatory-to-inhibitory switch, it is notable that IL-1b is per se sufficient to alter chloride concentrations when applied to primary neuronal cultures, suggesting that this cytokine may be at the root of the process. It was recently suggested that immune signaling in neurons may converge upon mammalian target of rapamycin, which acts as a regulatory hub integrating inputs from numerous upstream intracellular signalling pathways, many of which are altered in the brains of immunechallenged offspring (4). Consistently, IL-1b impinges on the mammalian target of rapamycin/protein kinase B pathway, eventually impacting brain plasticity processes (56). Of note, a selective increase of IL-1b levels was detected in the hippocampi of GD9 PolyI:C-treated offspring, further pointing to a crucial role of this cytokine (55).<br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-52992548818942599772020-04-06T17:47:58.462+02:002020-04-06T17:47:58.462+02:00Maja, thanks for sharing your experience in detail...Maja, thanks for sharing your experience in detail. <br /><br />I am not sure, was it Rifaximin or Pentoxifylline that made your daughter prone to viral infections and fever? <br /><br />Pentoxifylline caught my attention long ago: safe and cheap with anecdotal reports of efficacy in some autism and successful use to reduce DMF adverse effects. Not to mention it has been suggested in the cytokine storm mediated diseases. <br /><br />Here, OCD developed after adding acetazolamide to bumetanide and was coincident with cognitive improvement and clearly increased "pro-social approach". It was interpreted as a mean to cope with challenging situations and it still happens.Agnieszka Wroczyńskahttps://www.blogger.com/profile/04738535364585304041noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-67445033342710066452020-04-06T15:21:29.413+02:002020-04-06T15:21:29.413+02:00Peter, do you know by which pathways go from infla...Peter, do you know by which pathways go from inflammation to KCC2->NKCC1? <br /><br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-75162633234449531072020-04-05T23:10:24.534+02:002020-04-05T23:10:24.534+02:00Maja, thanks for all the detail.
It makes sense t...Maja, thanks for all the detail.<br /><br />It makes sense that Pentoxifylline works well with Bumetanide. Inflammation shifts the balance from KCC2 towards NKCC1, hence raising intracellular chloride. Since your daughter is a bumetanide responder she likely has elevated chloride. In her case both Pentoxifylline and Bumetanide are lowering chloride and thus providing the cognitive benefit.<br /><br />In our case, more cognitive awareness has the side effect of anxiety. This is what happens with the tiny dose of DMF if taken daily, it is like hyper-awareness. Not surprisingly this has some negative effects.<br /><br />I also think it may be a question of the child getting used to their "new normal", where they are fully aware of what is going on around them, for the first time in their life.<br /><br />Do you have any side effects of Pentoxifylline? Roflumilast and to a lesser extent Ibudilast can cause nausea. Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-28496687366500323522020-04-05T22:02:53.125+02:002020-04-05T22:02:53.125+02:00Hi Maja, thanks for posting your experiences!
It i...Hi Maja, thanks for posting your experiences!<br />It is interesting that you see Pentoxifylline work in synergy with Bumetanide. The same seems to apply to Ibudilast, another PDE inhibitor. <br />Did you ever try NAC? I've had some success with OCD with Fisetin/Bacopa but the mechanism is not clear - either on serotonin receptors, anti-oxidant or immunomodulation. In my world OCD is linked to NMDA receptors - either you want to raise their function or lower it. Memantine seems harmless to try, not sure you will see any effect.<br />I hope you find something that works!<br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-27075761698370362912020-04-05T11:55:27.149+02:002020-04-05T11:55:27.149+02:001) Yes, she does have SIBO.
It has been the most p...1) Yes, she does have SIBO.<br />It has been the most prominent sign of hers autism. It presented with the pain in the lower abdomen, most intense on the right side, with burping, swelling, hiccup... <br />She even fainted few times on the street because of it. <br />Periods of fatigue developed when she was eight. It looked like her fitness became very poor.<br />She had seborrheic dermatitis on the head, all over it; it was painful and bleeding from time to time. Acnes were on her forehead and greasy flakes on her nose.<br />She had no attention. It was very difficult to communicate with her, even basic. <br />All of that has gone with the Rifaximin in a few weeks. It was a dramatic improvement.<br />However, with improvement, stereotypes have increased. OCD become so big, that I even wanted to stop Rifaximin.<br />But I didn't - self-awareness doesn't have a price.<br />I have been giving Rifaximin for almost 4 years - now every fourth month. In the beginning, every second or third month. The dose is different, depends on symptoms - sometimes it is 2x600mg, mostly 2x400mg. And the duration of treatment varies - from 3-10 days. The dose and duration of therapy depend only on my judgment.<br /><br />2) Pentoxifylline is not causing the OCD. It does its job as an immunomodulator.<br />I'll try to explain...<br />Rifaximin has cleared up the main signs of inflammation. <br />Surprisingly, after that treatment, my daughter started to contract easily the current viruses, she was even febrile more than a few times. She hasn’t been febrile since she was three, till that time. (That is a part of another story; after all the thinking, I still don't know is it good or bad.)<br />A few days before the clinical signs of viral infections, she goes deeper into autism - remarkably less present and more stupid. The visible signs are acne on forehead wich poop up very fast.<br />Pentoxifylline reduces these symptoms. Less stupidity and no acnes before the development of the symptoms of virus infection, allergic rhinosinusitis or changing a milk tooth.<br />It makes Bumetanide work better (tried them together and separately)<br />It seems to me that the angry outbursts are reduced; tantrums have not been developed even when they are expected.<br /><br />3) OCD remains after all. Even bigger. Phobias, fears, anxiousness - blossom.<br />The list of scary terms grows - death, injuries, illness, characters from some movies, sounds, musical instruments - name it, we have it!<br />I know that she is safe in OCD, I know that coming back to the real world after more than 10 years of absence is scary - but now she has a psychological disorder. She tries so hard not to listen; covers her ears, talks parallel to me - trying to make me change the subject and speak what she wants.<br />OCD is marching side by side with self-awareness.<br />After all, I have the same - child out of real life.<br /><br />4) Pioglitazone, even harmless, has many side effects. I don't have nerves for that.<br />I didn't know that Celecoxib reduces the OCD, even not taken regularly, thank you, Peter.<br /><br />Maja<br />majadjhttps://www.blogger.com/profile/07148852308130407488noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-74382806049306370492020-04-04T23:22:07.551+02:002020-04-04T23:22:07.551+02:00Maja, I did not try Memantine, but it clearly does...Maja, I did not try Memantine, but it clearly does work for some types of OCD.<br /><br />Pentoxifylline was popular many years ago as a immunomodulatory autism therapy. You think this is causing the OCD? Did you consider Pioglitazone as an immunomodulator? This clearly does work for some people.<br /><br />Memantine is certainly worth a try, but I think many things can drive OCD.<br /><br />You might try and see if Celocoxib reduces the OCD, even if you do not want to use it regularly.<br /><br />How often do you give Rifaximin? Did you have symptoms of SIBO beforehand?Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-6823975946504524262020-04-04T17:12:37.553+02:002020-04-04T17:12:37.553+02:00Daughter, ASD, age 15
She has been "present&q...Daughter, ASD, age 15<br />She has been "present" since the Rifaximin was introduced a few years ago. <br />This become more pronounced with Bumetanide in small dose (1mg).<br />She asked questions she has never asked ("Who are you talking to on the phone, mama?"; "What did you say?"...)<br />The oscillations in her behavior were still present a great deal at that time.<br />By introducing a Pentoxifylline (400 mg), the exacerbations have become less prominent.<br />She still has a short fuse, but has it under control; didn't have tantrums at all in the last few months.<br />But, in other hand, stimming and OCD are up to the roof, helping her to escape from real life.<br />I am willing to add Memantine... Did you try it, Peter, please?<br /><br /><br />majadjhttps://www.blogger.com/profile/07148852308130407488noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-55509225286762273252018-11-08T22:32:25.386+01:002018-11-08T22:32:25.386+01:00Aspie1983, you could very well be right. My commen...Aspie1983, you could very well be right. My comment is based on people with a confirmed genetic hypo/hyperfunction, and for them it is of course hypo or hyper all over the brain and not a mixed version.<br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-88689106610669988312018-11-08T16:34:00.139+01:002018-11-08T16:34:00.139+01:00Ling, Memantine has a powerfull effect on NMDA cha...Ling, Memantine has a powerfull effect on NMDA channels, even at the 5mg I was taking per day. It definetely brought a drastic improvement in mood.<br />Also it isnt as easy as hypo or hyper function... I have tried to explain this before, a person can have hypo function in one brain area while hyper function in another, its complex, its not an on/off lightswitch.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-10387737170419359432018-11-08T09:23:20.236+01:002018-11-08T09:23:20.236+01:00Tatjana, you will always have a risk of epilepsy w...Tatjana, you will always have a risk of epilepsy when you use drugs that target NMDA signalling. You need to know if you are treating hypo- or hyperfunction, otherwise you might push things in the wrong direction. Memantine is for hyperfunction, but what I’ve read is that it isn’t superefficient, at least not in the long run. Maybe it needs to be cycled. I know people with confirmed hypofunction who tried it before knowing about it who just found it ”unefficient” and not ”disastrous”.<br /><br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-47461202988910090942018-11-07T13:55:25.285+01:002018-11-07T13:55:25.285+01:00Tatjana, meds are always a double edge sword I hav...Tatjana, meds are always a double edge sword I have noticed. Despite my criticism above I would like to point out that memantine is extremely potent for lifting mood, in fact I feel as if it helped with work/stress aswell due to making experiences more rewarding. When someone enjoys doing an activity/school/work its obviously less stressfull while on memantine. At times I do feel as if taking it again (I wouldnt necesarrily say it is addicting/reinforcing), however what is striking (and I have said this on reddit aswell). The new songs I introduced to my playlist on youtube while I was on memantine still sound better now than other songs! I know it sounds crazy but they give me mesmerizing thoughts and it feels as if they have more 'soul'. Once again its very hard for me to put into words, but from what I have read this is pretty common for NMDA antagonists. In fact I can understand how drugs like PCP must be extremely addicting.<br /><br />Also I should add that I went straight for 5mg on starting memantine, I would advice anyone who wants to try it go for 2.5mg/day (or even make a solution somehow and start at 1.25mg).<br /><br />Problem with my pills were that they are 10mg (they do have a breakline) and when splitting them its a friggin mess (huge fail on the pharmacy/production their side imo), especially considering the halflife is like 70hours!<br />Also when stopping memantine I basically went from last day on 5mg, then i crushed the half part of the 5mg into a powder and took half of it, so 2.5mg, then after that I completely stopped because I had read on reddit that due the long halflife slowly decreasing dose wasnt necesarry so that might have played an effect aswell in my strong flu like response.<br />I would strongly suggest building up the dose very slow and if stopping, gradually decreasing the dose very slow also.<br />Because despite not noticing any mood changes while the drug was being washed out of my system it clearly had a strong effect on my immune system while both starting the drug and stopping (but not while I was daily doing it).<br /><br />Also memantine seems to work best for those with social dullness/lack of responding to interaction with parents etc/lack of reward from social interaction. In other words high functioning autism/aspergers it seems to be best for.<br /><br />Also I wonder how much its nACHr antagonism is at play for mood, for example I respond absolutely HORRIBLE to galantamine, gives a similar feeling as clonazepam low dose, aggression, excess cognition, irritability.<br /><br />Its also one of the reasons I have considered asking my psych for bupropion, but first things first: donepezil first and then if needed bumetanide after that.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-55076581059115488372018-11-06T23:32:06.707+01:002018-11-06T23:32:06.707+01:00I got a memantine script for my kid and even bough...I got a memantine script for my kid and even bought it. Then i read the side effects list and saw seizures. I am lucky in that my kid never had one and I think all autistic children or adults - since they are so prone to them and it can be so hard to get rid off - should stay clear of any meds with the potential to introduce seizures into their life. I think its a drug despairing people with autistic kids high up on the spectrum will try and for good reason, but for most people reading this blog, I don’t think its worth the risk.Tatjanahttps://www.blogger.com/profile/00856934973958247860noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-6305961130894599032018-11-05T21:56:30.494+01:002018-11-05T21:56:30.494+01:00Hope anyone reads this before they decide to use m...Hope anyone reads this before they decide to use memantine or not:<br /><br />Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness<br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288222/<br /><br />I was feeling ill/headaches/neck pain on onset of starting memantine and was severely ill when I stopped it (had fever for 2 weeks, puking like mad, passed out 4 times).<br /><br />Thus, standard doses of memantine profoundly reduce T cell responses in treated patients through blockade of Kv1.3 channels. This may normalize deviant immunopathology in AD and contribute to the beneficial effects of memantine, but may also account for the enhanced infection rate. <<<---------------------<br /><br />Like I suspected (I couldnt find any information on it before untill now!) memantine influences the immunesystem, which also makes sense since amantadine (structurally very closely related is an antiviral!).Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-69649701966370280422018-05-24T16:36:48.788+02:002018-05-24T16:36:48.788+02:00Thank you very much, Peter !!Thank you very much, Peter !!Luishttps://www.blogger.com/profile/15511835233235446508noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-52380928707825669672018-05-07T00:18:54.427+02:002018-05-07T00:18:54.427+02:00Luis, Bumetanide has the effect of moving chloride...Luis, Bumetanide has the effect of moving chloride rather than disposing of it. It lowers the level inside neurons by increasing the level outside. Your body needs chloride and all electrolytes to be able to function, but they need to be in the right place. In autism chloride, calcium and even zinc can be in the wrong place. If you stop bumetanide, after a few days chloride just moves back to the wrong place (inside neurons). Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-19098040456837556752018-05-06T04:41:35.825+02:002018-05-06T04:41:35.825+02:00Hello Peter,
This is a very old post, so I don'...Hello Peter,<br />This is a very old post, so I don't know if you're going to read my question. If Bumetanide promotes Chloride excretion, I was hoping that it could bring real steady gains, even if we stop it. Maybe like heavy metals chelation. I mean, if the Chloride excretion is enough to change GABA to its inhibitory function, if we stop Bumetanide would another increase in Chloride change it again to excitatory ?Luishttps://www.blogger.com/profile/15511835233235446508noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-78031056363238137992018-01-10T20:38:56.471+01:002018-01-10T20:38:56.471+01:00Quick update on my memantine trial:
So I have bee...Quick update on my memantine trial:<br /><br />So I have been on memantine now for about 4-5 weeks, started of at 5mg, kept this dose for around 3 weeks.<br />Then 4 weeks in I talked with my doc. if I should raise the dose to try get more benefits out of it, so I took 10mg for 3 days and the spaced out feeling and euphoria came back again, it feels as if I go above 5mg/day the dopamine d2 agonism kicks in a bit too much for liking.<br />Anyhow, I have gone back down to 5mg and it still working very well, especially with stress reduction and filtering of information. However it does not do alot for my social issues.<br /><br />So about a week ago I tried about emoxypine a few times in combination and it seems to have a very nice synergism, its seriously so much easier to communicate with others, however it seemed to lower my arousal (was using 125mg capsules, maybe I could try take half a capsule or even a quarter).<br /><br />Also as of the last 2 days I decided to try piracetam (1600mg in the morning) another time and holy shit (pardon for the words! :P) this brings joy back to my life! Not the fake stimulant type of joy where you know your being stimmed (such as ritalin), but joy on moments that something triggers me, as an amplification of my emotions! (which is exactly what Im looking for in a med!). Also it seems that cordyceps also acts on AMPA receptors as a potentiator for its antidepressant effects, so im guessing AMPA is very important atleast for me.<br /><br />Now I know memantine is a sigma1 agonist/d2 agonist/5ht3 antagonist/NMDA antagonist and combining with piracetam (AMPA Positive allosteric modulators and known increase glutamate fireing, which is critical for learning) could have lead to interaction, however I feel absolutely zero side effects on using both together.<br /><br />I do have felt the last week or so that it is as if I no longer need memantine (I have kept taking my 5mg dose though). Im planning to cut back to 2.5mg/day in about a week from now and see how it goes.<br /><br />Now that I know that AMPA activation is very beneficial to me I have looked into other racetams and oxiracetam seems to fit the bill for me alot (AMPA PAM and PKC activator) so I might try that in the future, anyhow im so incredibly happy that piracetam is working so well for me and I can see how side effects such as mania are listed on the wikipedia page.<br /><br />Hope this helps someone out who is reading this that also has aspergers.<br /><br />______________________<br /><br />My current stack:<br /><br />AMPA/NMDA/cognition:<br />* Memantine 5mg<br />* Piracetam 1800mg<br />* Cordyceps militaris (ran out but its on its way) 3000mg<br />* CDP-Choline 250mg<br />* Phosphatidic acid 400mg<br />* Phosphatidylserine 400mg<br /><br />Mitochondria:<br />* PQQ 20mg<br />* COQ10 300mg<br />* GPLC 1500-3000mg<br /><br />Fatty acids and vitamins:<br />* Vitamin C 3gram<br />* Vitamin E 400iu<br />* Vitamin D3 2000iu<br />* Arachidonic acid 300mg<br />* DHA 250mg<br />* EPA 125mg<br /><br />Brain blood flow:<br />* Citrulline 3gram<br />* Norvaline (arrived today, so adding a tiny amount and possibly lowering my citrulline to 1500mg daily)<br />* Taurine 3gram<br /><br />Gut health:<br />* Eliminate all bread from diet<br />* Colostrum 2gram (1gram bi-daily)<br />* 300-500ml of yoghurt with biogarde cultures<br /><br />Sleep:<br />* Lysine 1gram<br />* Magnesium oil (transdermal spray)<br />* Damiana 5gram<br /><br />_________<br /><br />My clostridicum butyricum had arrived halfway december by the way and I used it 2-3 times and it seems to give me an inflammation reaction this time!!! my skin became bright red hot, was literally shocked! I absolutely did not have this a year ago when I gone to 2-3 bottles.<br />I cant dig up the study right now but there is a study out there showing that after about 40-50 weeks c. butyricum can actually increase il-17, this might explain what happened to me? Once again it is sooooooo odd, It feels as if it has permanently altered my gut health from when I used it a year ago up till now, but whenever I use it now it seems to work against me? very very odd.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-14360160727326656352017-12-14T22:29:21.322+01:002017-12-14T22:29:21.322+01:00Brief update on memantine, today has been day 7 on...Brief update on memantine, today has been day 7 on it, the side effects that I have mentioned before seem to have greatly diminished (for those planning on using memantine in the future I have found that cutting out on caffeine/coffee, increasing magnesium intake and vasodilators such as citrulline help mitigate the tense muscles in the neck and earpressure).<br /><br />So far I have only used up to 5mg and im planning on using 5mg atleast 2-3 days more before possibly moving to 7.5mg.<br /><br />The effects so far: far far less stress when bumping into several daily stressors (this is where it shines, it seems to erase bad thoughts pretty much instantly) allowing me to continue with my daily life, cognition definatly improved, wayyyy less overthinking, more living in the NOW - less living and in the future, being able to relax, anxiety is down, minor improvement in sense of reward from achieving small things, find myself laughing spontaneously more often, more energy overall daily.<br /><br />However (atleast so far) I have not found myself having more of an urge for social interaction, but when I do talk to people I definatly feel more at ease (and oddly, less aroused). I know it is still early on and hopefully these things will improve.<br /><br />Planning on using it for 2-3months (Im sure I will have a good impression of its effects by then).<br /><br />So far I would give it a 8 out of 10 in terms of reduction of my symptoms, however it feels as if something is lacking.<br />Day 1 on memantine was quite euphoric and exciting, I suspect this was due to memantine hitting my system and the anticholinergic effects kicking in. As states before chronic use of memantine upregulate alpha7 nACHr.<br />I have experimented with nutmeg twice (dont try this at home!) which has strong anticholinergic properties and found it extremely rewarding, very good social lubricant, spontaneous social behavior.<br /><br />After memantine im planning on trying the following:<br /><br />*Afobazole<br />sigma agonist and mt1 (melatonin receptor 1) agonist<br />https://en.wikipedia.org/wiki/Fabomotizole<br /><br />*Emoxypine<br />anxiolytic which increases brain phosphatidylinositol and other phospholipids and does tons more good things<br />https://en.wikipedia.org/wiki/Emoxypine<br /><br />*Pantogam<br />https://en.wikipedia.org/wiki/Hopantenic_acid<br /><br />*Etifoxine (possibly)<br />anxiolytic and anticonvulsant drug, stimulates synthesis of neurosteroids (brain steroids)<br />https://en.wikipedia.org/wiki/Etifoxine<br /><br /><br /><br />*Metaprot (bemitil)<br />acroprotector, nootropic, antihypoxic, antioxidant, immunomodulatory activity, treat brain fever, effective in restoring and enhancing physical and mental performances. It increases resistance to extreme factors such as stress, hypoxia, hyperthermia and physical activity without increasing oxygen consumption or heat production. Metaprot is used to treat asthenic disorders of various nature (in neurasthenia, somatic disorders). Also used in a combination therapy in cerebral circulation dysfunction and cognitive disorders.<br /><br />http://rupharma.com/metaprot/<br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762282/Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-56281834217933348712017-12-14T11:54:04.629+01:002017-12-14T11:54:04.629+01:00Peter,
We as parents trudge on, trying to acheive...Peter,<br /><br />We as parents trudge on, trying to acheive that delicate balance where our primary commitment to provide maximum physical and emotional security to our kids is not compromised through our attempts at furthering their intellectual/cognitive growth. We all want healthy kids...health in its widest definition. Its one thing to trial and experiment on oneself and altogether different to do things to a young child who has no autonomy or control over what is being done....physical side effects of drugs, emotional trauma of educational and behavioural drills and a limited capacity to communicate. Its such a dilemma for us. When I was barely four or five my mother had read out a poem 'The Blue Rose' and when she finished all of us were crying. Now I am a doting mother to blue rose....not crying but trudging on..keeping the faith.Kritikanoreply@blogger.com