tag:blogger.com,1999:blog-655962722302095847.post3934344313311117701..comments2024-03-28T20:30:37.506+01:00Comments on Epiphany: The CDC Suggests People with Severe Autism are at Elevated Risk from Covid-19 – Time to ACE it?Peter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger37125tag:blogger.com,1999:blog-655962722302095847.post-2629473807832523172020-03-31T07:22:12.437+02:002020-03-31T07:22:12.437+02:00Martin, you can subdivide pills by crushing them a...Martin, you can subdivide pills by crushing them and then using cheap micro-scales to weigh small amounts.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-73537576978908371752020-03-30T17:30:05.734+02:002020-03-30T17:30:05.734+02:00Researchers were proposing a minimum of 20mg sever...Researchers were proposing a minimum of 20mg several times per day in the Ebola outbreak.<br /><br />"Key issues related to the use of melatonin probably include early intervention with a large dose (20 mg or more for a single dose; as there is no precedent for an effective melatonin dose, some upward adjustment of the dose may have greater efficacy); this dose should be given several times per day for a prolonged period. The treatment should be initiated as soon as possible after the infection is diagnosed; presumably it would never be too late to begin treatment (orally or i.v.). Considering the current lack of effective treatments for this devastating disease and with no vaccine available for EVD, the use of melatonin would be worth consideration."<br /><br />https://onlinelibrary.wiley.com/doi/full/10.1111/jpi.12186<br />Mark5:28https://www.blogger.com/profile/06132555911178761617noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-57373493381639862362020-03-30T15:42:13.561+02:002020-03-30T15:42:13.561+02:00Peter,
I am currently using 50mg sertraline t...Peter,<br /> I am currently using 50mg sertraline tabs with an indented middle. I am planning on trying 25 twice a day starting tonight or tomorrow. I can try asking for 25mg tabs on my psychiatrist appointment this week. I just worry that won't even consider it. If that's the case I'm just keeping my fluvoxamine since it's harder to get. My formulary has sertraline 20mg/ml oral concentrate I just saw, but I'm not sure that's needed vs a 25mg tab since I'm an adult?<br /><br />Thanks Peter & all<br />-MartinMartinhttps://www.blogger.com/profile/00639360425631629172noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-16440436069729010452020-03-30T11:32:13.186+02:002020-03-30T11:32:13.186+02:00Martin, for an adult the low dose sertraline would...Martin, for an adult the low dose sertraline would be about 10mg a day. You would have to experiment to see the effect. <br />The effect on neurosteroids may also be present at high doses and partly cause their therapeutic effect.<br /><br />The interest in low dose Sertraline is because it would likely be free of the common SSRI side effects and be suitable for long term use. Many people find SSRIs problematic.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-84375663651517497862020-03-30T11:20:17.995+02:002020-03-30T11:20:17.995+02:00Hi Peter,
Does the sertraline have to microdosed ...Hi Peter,<br /><br />Does the sertraline have to microdosed to get the effect of sertraline described above?<br /><br /> I have been trying 50mg sertraline with 150mg fluvoxamine without increase in side effects. Another thought I had was sertraline only in the morning and fluvoxamine only at night. Right I take them together every 12 hours<br /><br />I'm also trying to get a leucovorin prescription from my neurologist or psychiatrist. Martinhttps://www.blogger.com/profile/00639360425631629172noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-44063248150085715782020-03-30T09:34:55.229+02:002020-03-30T09:34:55.229+02:00It looks like the effect on neurosteroids in the b...It looks like the effect on neurosteroids in the brain varies between SSRIs.<br /><br />Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes<br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23979/<br /><br />Our results indicate that the SSRIs fluoxetine, sertraline, and paroxetine decrease the Km of the conversion of 5α-dihydroprogesterone to allopregnanolone by human 3α-HSD type III 10- to 30-fold. Only sertraline inhibited the reverse oxidative reaction. SSRIs also affected conversions of androgens to 3α- and 3α, 17β-reduced or -oxidized androgens mediated by 3α-HSD type IIBrain. Another antidepressant, imipramine, was without any effect on allopregnanolone or androstanediol production<br /><br />I suppose nobody has considered combining SSRIs.<br /><br />The 1/10th dose of Sertraline is not supposed to have an effect on serotonin, but if you are already taking a regular dose of Fluvoxamine, that might not hold true. <br /><br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-56931970937186611892020-03-29T23:30:56.708+02:002020-03-29T23:30:56.708+02:00I have used, and upheard of doses up to 100mg a da...I have used, and upheard of doses up to 100mg a day without side effects other than maybe feeling groggy. I would say it's anti-inflammatory on how it feels to me. I have been using more since covid just because I'm stressed.<br /><br />Generally, I only take one 10mg extended release with 10mg pyridoxine hydrochloride. I keep immediate release if I can't fall back asleep or have a pounding migraine.Martinhttps://www.blogger.com/profile/00639360425631629172noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-15235517429250271732020-03-29T23:16:25.610+02:002020-03-29T23:16:25.610+02:00Can a smaller sertraline dose be added to fluvoxam...Can a smaller sertraline dose be added to fluvoxamine?Martinhttps://www.blogger.com/profile/00639360425631629172noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-10267500260732833802020-03-29T00:25:47.227+01:002020-03-29T00:25:47.227+01:00Roger, your neuropathy is autoimmune - have you re...Roger, your neuropathy is autoimmune - have you read it is best to avoid use of melatonin if there is an autoimmune condition? I have read about a mouse study where lupus in male mice treated with melatonin worsened, but improved for the female mice <br />~TanyaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-88338742464817349842020-03-27T18:59:00.546+01:002020-03-27T18:59:00.546+01:00Agniezka- Could the Ibuprofen issue been an indivi...Agniezka- Could the Ibuprofen issue been an individual response? A metabolic inflammatory type of response that aggravated those with current COVID? I just found out that my son has issues with Salicylates and this is very complex in of itself? I was noticing various sensitivities and taking notes of the chemical properties of the most serious offenders. One of my relatives went undiagnosed while going through it. Because her test was misplaced she was treated with Nebulizer steroids, azithromycin, and low dose Klonopin. She survived. The Melatonin research sounds very promision.Never Give Uphttps://www.blogger.com/profile/02812381930735127144noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-45943913010838748412020-03-25T22:59:27.003+01:002020-03-25T22:59:27.003+01:00Big thanks to everyone helping out to navigate aut...Big thanks to everyone helping out to navigate autism drugs during the pandemic. I posted a question on Ibudilast which probably was lost during transmission, but I might have found the answer anyway. I wondered if it would be OK with Ibudilast for someone with corona symptoms, and while the below is part of a press release (so comparable to an advertisement), it indicates someone believes it would:<br /><br />10 March 2020 <br />"MediciNova today announced that it plans to initiate development of MN-166 (ibudilast) for severe pneumonia and acute respiratory distress syndrome (ARDS). (..)<br />Results of this preclinical study showed that ibudilast treatment reversed histological changes observed in the ARDS mouse model including inflammation, hemorrhage, alveolar congestion, and alveolar wall edema. (..)<br />Results of this study also showed that ibudilast significantly reduced the levels of inflammatory cytokines including TNF-alpha, IL-1beta, IL-6, and MCP-1 in a dose-dependent manner, indicating that ibudilast suppressed the inflammatory response.<br />(..)<br />Infections are the most common risk factors for ARDS. These infections may include the flu, coronavirus or other viruses, and sepsis." https://apnews.com/Globe%20Newswire/90bc10948a0c9ce68d8417ab9b944d7a<br /><br />/Ling (sorry for the bad reliability of my source this time)Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-57327020129456710282020-03-25T14:46:45.667+01:002020-03-25T14:46:45.667+01:00Bumetanide and low dose Sertraline/Zoloft are chan...Bumetanide and low dose Sertraline/Zoloft are changing the effect of GABA rather than "using it up". You could try using less Sertraline/Zoloft or giving it every second day.<br /><br />You should realize that you are, in-effect, giving your daughter Allopregnanolone<br /><br />https://en.wikipedia.org/wiki/Allopregnanolone<br /><br />Read about its effects other than on GABA and how it has a biphasic action on GABAa receptors.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-27391837808453260352020-03-25T12:26:48.075+01:002020-03-25T12:26:48.075+01:00There are no listed interactions. I was thinking a...There are no listed interactions. I was thinking along the lines of Gaba. The whinging I take as a sign that something is off - maybe she needs more precursors for gaba or dopamine or serotonin if ‘spending’ is more increased now? Just trying to fine tune this, because the whinging is impeding her learning and social interactions. tpeshttps://www.blogger.com/profile/01788229993969295249noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-68282835774817257372020-03-25T11:22:49.028+01:002020-03-25T11:22:49.028+01:00tpes, drug interactions are common and may not rel...tpes, drug interactions are common and may not relate to the therapeutic function of the drug. Your SSRI may interact with your immune therapies.<br /><br />It is best to look up all the drugs and see if they have a listed interaction with Sertraline (Zoloft).<br /><br />https://www.drugbank.ca/drugs/DB01104 <br /><br />Your tiny 1/10th dose of Sertraline is likely to increase Allopregnanolone. This modifies the response from GABAa receptors and may benefit some people.<br /><br />There is no listed interaction with Bumetanide. But if someone has autism, there is an interaction, because both drugs can affect GABAa receptors. Sertraline has a long half life and the effect of bumetanide on GABA also has, in effect, a long half-life. So the timing of the low dose of Sertraline and the bumetanide dose should not really matter (in theory), but you can always vary the timing and see if it has an effect.<br /><br />The more drugs and supplements you use, the greater the chance of some kind of interaction, but that does not mean it is a harmful interaction; winging is not really harmful. The listed interactions are the potentially harmful ones.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-55527028383325801542020-03-24T23:35:25.095+01:002020-03-24T23:35:25.095+01:00 question about the ssri use: the past 2 days we h... question about the ssri use: the past 2 days we have seen a very visible routine. in the morning absolutely blowing us away. after bumetanide, sort of whiny, closed off, wants to do what she wants. ssri around 15h. around 18h a spirt of energy, playing, communicating. normal bedtime behaviour, maybe bit increased silliness. we worry that the noon whinging is caused by some overlap of the ssri with the bumetanide. all her other therapies are immunity related and should not be overlapping with this. any ideas?tpeshttps://www.blogger.com/profile/01788229993969295249noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-17900177297483676842020-03-24T16:05:12.035+01:002020-03-24T16:05:12.035+01:00I have been pleasantly surprised to hear in my Pan...I have been pleasantly surprised to hear in my Pandas groups on FB that the british NHS has put Pandas children in the highest risk group and they all received phonecalls/sms/letters urging them to stay put for 12 weeks. Its good to know that the condition which often accompanies asd is taken seriously at least by some. I have asked the members to tell me more, if there are any interesting infos I will pass them on. Its devastating that children with asd, of whom I can bet not one has a properly functioning immune system, will not get this treatment. tpeshttps://www.blogger.com/profile/01788229993969295249noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-88992823468175421902020-03-23T12:22:59.929+01:002020-03-23T12:22:59.929+01:00Alinia an anti malarial has broad anti viral effec...Alinia an anti malarial has broad anti viral effects including against a number of animal and human corona viruses. Paper by Chinese researchers and table 1 summarizes: https://mmrjournal.biomedcentral.com/articles/10.1186/s40779-020-00240-0 <br /><br />Other Chinese researchers published a w/holistic meta analysis outlining Cv interventions used in China. It spans vitamins, traditional Chinese medicine, to anti virals. https://onlinelibrary.wiley.com/doi/10.1002/jmv.25707<br /><br />Canadians are also trialing quercetin in China for Cv; it worked in animal trials against SARS, MERS, Zika. <br />https://journal.com.ph/news/world/breaking-news-can-quercetin-help-us-avoid-threat-coronavirus-infection<br /><br />Flavonoids like quercetin also have an inhibitory effect on ACE1 which Cv evidently uses to trigger ACE2 invoking cytokine storms<br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504033/Ted Huhttps://www.blogger.com/profile/18026309719234913544noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-12963997445797542172020-03-22T20:20:07.435+01:002020-03-22T20:20:07.435+01:00Peter -
Regarding IVIG, my 19 yo son is currently...Peter - <br />Regarding IVIG, my 19 yo son is currently getting monthly IVIG treatments...so from the above, it appears that IVIG is helpful and not contra-indicated in this Covid-19 environment. Is that your understanding, as well? Your thoughts would be appreciated!RGLhttps://www.blogger.com/profile/05484647549832270651noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-33470545978368944672020-03-22T19:44:30.962+01:002020-03-22T19:44:30.962+01:00What are the scientific evidences for variations i...What are the scientific evidences for variations in the gene that produces ACE2 in italian people? ..anyway the first patient in Codogno (Lombardia) was a marathon runner...this 38 y.o. man is now recovered but his father died carla marta locked since 11 marchAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-76525719640031966962020-03-22T13:58:33.501+01:002020-03-22T13:58:33.501+01:00Can anybody tell me where to buy azosemide , I can...Can anybody tell me where to buy azosemide , I can not find it<br />Thank youJorgehttps://www.blogger.com/profile/00004711886814419078noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-31285137944891010272020-03-21T21:38:56.509+01:002020-03-21T21:38:56.509+01:00tpes, that is great.
The idea of 1/10 dose SSRIs ...tpes, that is great.<br /><br />The idea of 1/10 dose SSRIs was covered here:- <br /><br />When is an SSRI not an SSRI? Low dose SSRIs as Selective Brain Steroidogenic Stimulants (SBSSs) via Allopregnanolone modifying GABAa receptors and neonatal KCC2 expression<br /><br />https://epiphanyasd.blogspot.com/2018/11/when-is-ssri-not-ssri-low-dose-ssris-as.html<br /><br />It only seems to work in some people. Some Aspies have tried it and complain it has no effect.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-54022690920575154642020-03-21T20:48:55.561+01:002020-03-21T20:48:55.561+01:003 days in I am overwhelmed by the amazing things 2...3 days in I am overwhelmed by the amazing things 2.5mg of Zoloft has brought us. Great mood, spontaneous shows of knowledge (at dinner time we do some typing on the Ipad, more as a typing exercise and general letter skills than real writing - she sent me for a glass of water and typed the whole alphabet in the meantime, which she has only seen in an app not even designet to teach you the alphabet), more direct communication. Love it!!! tpeshttps://www.blogger.com/profile/01788229993969295249noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-55781609738331522612020-03-21T19:54:31.465+01:002020-03-21T19:54:31.465+01:00Okido. I remember the topic was up a while ago and...Okido. I remember the topic was up a while ago and I thought you maybe even asked for technical help at some point(?) I happened to have someone close who'd be able to work on it now, pro bono, which is why I'm asking. <br /><br />ANyway, just don't underestimate how valuable this blog is. While it doesn't sell stuff, it saves families. That has to count as something.<br /><br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-12632568423705313132020-03-21T10:26:14.463+01:002020-03-21T10:26:14.463+01:00Ling, unless Google shut down the platform, it is ...Ling, unless Google shut down the platform, it is best to leave the blog where it is. It works, it is free and has no advertising.<br /><br />It is not a commercial operation trying to sell things, so it does not need to be super slick.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-59354486984024048972020-03-20T21:10:16.190+01:002020-03-20T21:10:16.190+01:00Peter, do you have any thoughts or wishes about mi...Peter, do you have any thoughts or wishes about migrating the blog from blogspot to some other platform? Requirements?<br />I can't promise anything yet, but I want to know if it's worth the effort to look into it.<br /><br />/Ling Anonymousnoreply@blogger.com