tag:blogger.com,1999:blog-655962722302095847.post2991620623439691563..comments2024-03-29T08:14:42.258+01:00Comments on Epiphany: Matching Pathology with Behaviours in AutismPeter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger11125tag:blogger.com,1999:blog-655962722302095847.post-49742790470464121682015-07-01T08:48:54.387+02:002015-07-01T08:48:54.387+02:00Very interesting. Low dose clonazepam looks extrem...Very interesting. Low dose clonazepam looks extremely safe.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-81991784072605050502015-07-01T02:03:55.412+02:002015-07-01T02:03:55.412+02:00He is on a low dose of 20mg a day, given at breakf...He is on a low dose of 20mg a day, given at breakfast time. After 1 hour you can clearly see the beneficial effect it's having.<br /><br />I've read that it interacts with both verapamil and bumetanide, so those drugs are out for us now.<br /><br />However, I did come across something quite fascinating. After perusing social anxiety boards, I discovered that a number of people (non-autistics) are combining propranolol and low dose clonazepam to good effect.<br />NinaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-6152904322768682502015-06-30T14:09:07.765+02:002015-06-30T14:09:07.765+02:00Nina, that is great news. What dose of propranolo...Nina, that is great news. What dose of propranolol are you using?<br /><br />It is interesting that it is also used to treat migraines and cluster headaches.<br /><br />Note that it does interact with Verapamil.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-56565264921643302262015-06-30T13:57:06.771+02:002015-06-30T13:57:06.771+02:00I went ahead with a trial of propranolol for my so...I went ahead with a trial of propranolol for my son's anxiety and for us it's been very positive. Because anxiety was such a big problem before, being able to treat it has lead to several other improvements.<br /><br />Interestingly, I think non selective beta blockers may be having a stabilising effect on potassium levels, which would be a good thing too.<br />NinaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-32654335211733914012015-06-09T13:59:52.613+02:002015-06-09T13:59:52.613+02:00That's very interesting, thank you. I have bee...That's very interesting, thank you. I have been giving 2 x GABA a day and things have been worse. I will reassess my approach. Baclofen is definitely worth a try for anxiety, and I will look into bumetanide again once things have settled down.<br />NinaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-59359902805471030782015-06-09T05:59:20.386+02:002015-06-09T05:59:20.386+02:00Thank you. I am convinced that dysfunctional GABA ...Thank you. I am convinced that dysfunctional GABA is the main cause of my son's type of autism. And this is exacerbated by high histamine levels and allergies. I have a fairly forward thinking paediatrician and he prescribed GABA twice a day, but I'm guessing just adding more GABA when it is already dysfunctional won't make any difference.<br /><br />I will look into Baclofen. If I can find something that will actually help him that would be amazing, and I might start to see his true self. I will also try ibuprofen in advance of stressful situations and see if that helps. <br />NinaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-90355468964409474332015-06-08T14:48:06.925+02:002015-06-08T14:48:06.925+02:00Propranolol is used by some people to treat anxiet...Propranolol is used by some people to treat anxiety in autism.<br /><br />I had several exchanges recently with a UK pediatrician who is treating people with Asperger's for anxiety using Baclofen. The majority of kids responded to the treatment. Baclofen acts on GABAb. We know that GABA is dysfunctional in autism and so this might be the root problem in your child causing the anxiety. So you might want to consider Baclofen as an alternative to the propranolol.<br /><br />If drugs stop working I suggest you read this post:-<br /><br />http://epiphanyasd.blogspot.com/2015/06/primary-and-secondary-dysfunctions-in.html<br /><br />I would also suggest you try Ibuprofen in advance of a stressful event and see if it prevents the meltdown happening. If it helps then this would help identify what is happening.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-63652624811736185692015-06-08T14:20:07.431+02:002015-06-08T14:20:07.431+02:00Hi Peter
My 8yo with classic early onset autism su...Hi Peter<br />My 8yo with classic early onset autism suffers from terrible anxiety at times, and this leads to meltdowns. I have tried natural ways of boosting serotonin in the brain with little effect. I have been trying to implement your polypill step by step but the anxiety is getting in the way. I tried NAC and saw an immediate improvement - more affection, outgoing, willing to try new things but after a few days the effect disappeared. I supplemented with B vitamins but it didn't seem to have much effect. I tried bumetanide but stopped after one week as he was having panic attacks. I need to sort out the cause of the anxiety and panic attacks before I can try NAC and bumetanide again. <br />I am hoping that verapamil could be helpful as he has year round dust mite allergies and food allergies. Another drug I have considered is propranolol. What are your thoughts with beta blockers for autism? Thanks.<br />NinaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-39335249491533232812014-01-17T10:19:41.475+01:002014-01-17T10:19:41.475+01:00agreed,
for me, I will see bumetanide is also tre...agreed, <br />for me, I will see bumetanide is also treating one of the 'cores' of the diseases. [this also quoted in the sci web.]<br />These treatment may not cure the disease, but lead to improvement in multiple-areas.<br />like treatment of neuro-inflammation, I will see it as also treating the 'core'.<br /><br />others, will be symptoms management.<br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-25844005914531465082014-01-17T06:27:39.995+01:002014-01-17T06:27:39.995+01:00I am not convinced that the "core" of on...I am not convinced that the "core" of one child's autism is the same as the "core" of the others. This would explain why bumetanide and STX209 are not effective in all cases. Perhaps by lowering our expectations, we may actually achieve more, i.e. step by step improvements rather than "cure".Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-10737012049624908822014-01-17T02:22:33.307+01:002014-01-17T02:22:33.307+01:00Dear Peter,
I agree that what you described. But ...Dear Peter,<br /><br />I agree that what you described. But many parents are expecting a treatment for the ‘core’. For example, in case of bumetanide, lowing intracellular Cl level in brain leads to more aware of the environment, this will lead to improvement in many areas in a portion of subjects. STX209 has also been reported to treatment the ‘core’ of Fragile X successfully in a small portion of subjects. -Yi <br />Anonymousnoreply@blogger.com