tag:blogger.com,1999:blog-655962722302095847.post2629294860928305699..comments2024-03-27T20:20:54.505+01:00Comments on Epiphany: Sustained Release NAC for Autism and SchizophreniaPeter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger16125tag:blogger.com,1999:blog-655962722302095847.post-72276455782792327292018-11-12T21:09:15.236+01:002018-11-12T21:09:15.236+01:00Thank you to everyone who made an effort to answer...Thank you to everyone who made an effort to answer this non-topic question! Lots of differents angles to work from. <br /><br />While our efforts here are focused on the health of our small (and not-so-small-anymore) family members, there are often some older ones too that you care of almost as much.<br />Warm hugs to you all. <br />:)<br /><br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-81546731166687576532018-11-12T06:54:44.850+01:002018-11-12T06:54:44.850+01:00I had stiffness in my fingers and numbness in my a...I had stiffness in my fingers and numbness in my arms during night and sometimes in daytime too. No Diabetes, no carpal tunnel syndrome and no RA. Doctors concluded it was Degenerative arthritis. After watching a YouTube video I took 150 mg pyridoxine for 6 months and those symptoms were gone and now I am symptom free for the past one year.salempeacockhttps://www.blogger.com/profile/15527897267296882556noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-5519514306930524372018-11-11T16:26:07.966+01:002018-11-11T16:26:07.966+01:00Ling, it all depends on the type/cause of the neur...Ling, it all depends on the type/cause of the neuropathy. Start with that and then find the relevant therapies, a great deal is known.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-68403177252998614972018-11-11T09:19:35.872+01:002018-11-11T09:19:35.872+01:00My daughter has been taking mb12 shots like many a...My daughter has been taking mb12 shots like many asd kids. A friend of mine had a serious car accident that left her with an injured nerv in the shoulder, and neuropathy from the neck to the fingers. Her regular therapy included ALA and she hated the effects and was better off without them. They also recommended b12 injections and I have her a vial of mb12 for its superior bioavailability. It helped her tremendously, to the point that the pain would resurface whenever she skipped an injection. It was given as 0.04ml with a small angle subcutaneously - to form a ‘depot’ to dissolve in a few days - every 3 days. Tatjanahttps://www.blogger.com/profile/00856934973958247860noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-84054295386036638122018-11-10T23:24:47.829+01:002018-11-10T23:24:47.829+01:00Ling, there are different types of neuropathy and ...Ling, there are different types of neuropathy and in the case of diabetic neuropathy what counts as evidence based therapy depends where you live.<br /><br />In addition to ALA my father in law is treated in the government hospital in a hyperbaric chamber, which he says does indeed provide relief.<br /><br />Improved glucose control will help, as may increasing insulin sensitivity. Many supplements mentioned in this blog improve insulin sensitivity, ALA does this, as does beetroot juice, cinnamon, broccoli powder and berberine.<br /><br />If it was me, and I/V ALA was not an option, I would take a higher dose of ALA. Perhaps use ALA Sustain (same producer as NAC Sustain) 3 times a day.<br /><br />The prescription ALA is a hard tablet, which is likely more potent than gelatine capsule supplements.<br /><br />Take care because in the case of diabetic neuropathy all the above supplements will mean significantly less insulin will be needed. So blood sugar needs to be monitored carefully. <br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-59961598419248185802018-11-10T18:56:46.493+01:002018-11-10T18:56:46.493+01:00Peter, do you have any other suggestions for neuro...Peter, do you have any other suggestions for neuropathy? Looks like an old, loved one in my family has similar problems. I remembered you mentioning ALA so I bought a bottle of R-LA which works somewhat. <br /><br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-65878652981771477182018-11-09T10:02:58.027+01:002018-11-09T10:02:58.027+01:00Leigh-Roy, that is very interesting. Oral NAC has ...Leigh-Roy, that is very interesting. Oral NAC has just a 10% bioavailablity and then only a tiny part of that can cross into the brain.<br /><br />My father-in-law is treated 20 times a year with an intravenous infusion of ALA (very similar to NAC) and oral ALA the rest of the year. His doctor tells him that the infusion is 100x more effective than the tablet.<br /><br />He has diabetic neuropathy and, where we live, ALA is the standard mainstream medical treatment. In North America you would not find this in a big hospital setting.<br /><br />Hopefully a potent oral NAC will get commercialized.<br /><br />For now I will use the most potent form I can buy which is NAC Sustain. I think because it is a hard tablet, you still have most of the 600mg of NAC active, rather than degraded/oxidized. Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-56418626041781087392018-11-09T03:39:26.902+01:002018-11-09T03:39:26.902+01:00Hi Peter
Would love to hear your thoughts on this...Hi Peter<br /><br />Would love to hear your thoughts on this:<br />https://www.ncbi.nlm.nih.gov/pubmed/29680280Leigh-Royhttps://www.blogger.com/profile/04656199524061403821noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-15539375054542801662017-09-23T08:29:49.682+02:002017-09-23T08:29:49.682+02:00I would try all the drugs with some sound basis, t...I would try all the drugs with some sound basis, that includes Bumetanide. You cannot be sure what the precise benefit will be because we are all a little different. The important thing is to go one by one through them.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-85522188813414523112017-09-22T23:17:58.705+02:002017-09-22T23:17:58.705+02:00What about Bumetanide for sensory hypersensitivity...What about Bumetanide for sensory hypersensitivity?<br /><br />"The effect of bumetanide treatment on the sensory behaviours of a young girl with Asperger syndrome."<br />https://www.ncbi.nlm.nih.gov/pubmed/24488662<br /><br />In my child Bumetanide reduced sensory issues. <br />My own hypersensitivity resolved fully on NAC 600-1200 mg daily. It was of different kind than hyperacusis though.<br /><br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-28979862654303184012017-09-22T09:47:36.828+02:002017-09-22T09:47:36.828+02:00Since you have peripheral neuropathy, you might al...Since you have peripheral neuropathy, you might also try Alpha Lipoic Acid (ALA). ALA is very similar to NAC, but it is the choice used to treat peripheral neuropathy in countries with German or Russian based medicine.<br /><br />I think NAC sustain is the best form of NAC. We use 3 spread throughout the day.<br /><br />For sound sensitivity make a trial of potassium. You can read about hypokalemic sensory overload in this blog. This is a channelopathy.<br /><br />Many people with Asperger's, but not all, seem respond well to Baclofen.<br /><br />If you have allergy and headaches you might respond to Verapamil, which would treat a channelopathy. There is no diagnostic test.<br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-39169352093711375182017-09-22T05:13:07.174+02:002017-09-22T05:13:07.174+02:00Do you think it would be safe to take three of the...Do you think it would be safe to take three of these a day, each one 8 hours from each other, in order to ensure it stays in the blood constantly? Or would just two times a day be fine? I have Aspergers, some schizophrenia-like symptoms, and depersonalization disorder. I have confirmed heavy metal toxicity, immune abnormalities (heightened WBC frequently, low immunoglobulin subclass 2, etc) and medical symptoms that include peripheral neuropathy, chronic fatigue, and migraine. Anonymoushttps://www.blogger.com/profile/03744525984456991280noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-83410151390882179252015-05-06T09:18:52.225+02:002015-05-06T09:18:52.225+02:00I read that valproate is used for photosensitive e...I read that valproate is used for photosensitive epilepsy.<br /><br />I do not have any experience with epilepsy, however many of the drugs that affect autism also affect epilepsy. Even my latest interest in something called PPAR gamma, turns out to be a target drug for epilepsy.<br /><br />Bumetanide and micro-dose clonazepam both seem to have the same effect in autism (making GABA shift from excitatory to inhibitory) but the mechanism seems to be different. So one might work better for some people than for others; or you could use both.<br /><br />Clearly if the neurotransmitter GABA is working in "reverse" many other problems might then occur, including triggering seizures.<br /><br />So while nobody can tell you for sure what will work, all the drugs you mention should have an effect. Just as how Autism is not a biological diagnosis, neither is any kind of seizure diagnosis a precise diagnosis. Science and medicine do not yet have the required understanding/tools and so you are left with trial and error, or do nothing. Some people have very poorly controlled epilepsy and some seizure activity can have very serious consequences. So caution is necessary.<br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-32745824293079663752015-05-06T09:03:07.065+02:002015-05-06T09:03:07.065+02:00We use Verapamil 40 mg three times a day in the al...We use Verapamil 40 mg three times a day in the allergy season. In some countries there is a 120mg sustained release version, which might well work better.<br /><br />I have not looked at Andrographis, but it does look interesting and even shows an effect in Ulcerative Colitis. If it helps control the asthma, it might well be a good long term choice. Since it is widely sold, just look for any people talking about side effects.<br /><br />My son's asthma has disappeared as a side effect of his autism pills. He has not needed his Ventolin (Salbutamol) inhaler for many months, he just has a tiny dose of Flixotide (fluticasone). He also no longer gets colds, whereas his brother and classmates all do.<br /><br />It looks like you have adjusted your son's immune system, as we have also done.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-37780964754423888772015-05-06T02:10:34.227+02:002015-05-06T02:10:34.227+02:00Hello Peter, do you know what kind of antiepilepti...Hello Peter, do you know what kind of antiepileptic is used for photosenstive epilepsy?my son has epileptiform discharges in the occipital lobe, i was wondering if clonazepam and valproate would be better than bumetanide and valproate.I had told you that I realized something was wrong with my son when he watched fast and colorful cartoons when he was 2. he couldnt process images properly until now, but I dont give up.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-46715772591233308142015-05-05T21:19:15.482+02:002015-05-05T21:19:15.482+02:00We are doing bumetanide 3 times per day. My son is...We are doing bumetanide 3 times per day. My son is an asthma/allergies kid and we also see a spike in anxiety/irrability in the spring/summer. We just started adding Verapamil which seems to be helping with this. I’m wondering are you giving your son the time released Verapamil?<br /><br />I’m also wondering what your thoughts are about Andrographis. My son used to suffer horrible colds and asthma and now when cold symptoms start to develop we dose up on this and the cold never develops. It got me thinking about what other uses it might have and discovered this. Do you think it could be helpful taken long term?<br /><br />http://jpet.aspetjournals.org/content/308/3/975.full<br /><br />Thanks for your insights!Suenoreply@blogger.com