tag:blogger.com,1999:blog-655962722302095847.post2562184880884078075..comments2024-03-27T20:20:54.505+01:00Comments on Epiphany: Variable Expression of GABRA5 and Activation of α5 - a Modifier of Cognitive Function in Autism?Peter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger70125tag:blogger.com,1999:blog-655962722302095847.post-30739226265928539682023-08-02T22:48:26.300+02:002023-08-02T22:48:26.300+02:00Just in case anyone wanted to try Ozempic to help ...Just in case anyone wanted to try Ozempic to help treat autism. Glp1 helps with weight loss and is neuroprotective. <br /><br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405420/<br />Stephennoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-54643442147351085352018-12-14T12:47:39.554+01:002018-12-14T12:47:39.554+01:00To those who are looking to target gaba alpha5 as ...To those who are looking to target gaba alpha5 as discussed in Peters article:<br /><br />Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane<br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754839/<br /><br />Graph from study here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754839/figure/Fig5/?report=objectonly<br /><br />As you can see is that sulforaphane completely normalizes gaba a5 expression in a model of hyperammonia and nearly normalizes gaba a1 expression.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-39975578248307310822017-11-19T01:32:09.724+01:002017-11-19T01:32:09.724+01:00If he likes Michael Jackson, maybe you should intr...If he likes Michael Jackson, maybe you should introduce him to Weird Al Yankovic. To get my kids out the door in the morning and eat their breakfast, I blast "Eat It" by Weird Al on our Amazon Tap. That and "The Final Countdown" by Europe does the job these days.Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-49318500601850787742017-11-18T14:03:01.760+01:002017-11-18T14:03:01.760+01:00Reuteri atcc6475, decent at colonizing after all?
...Reuteri atcc6475, decent at colonizing after all?<br /><br />https://www.biogaia.com/pressrelease/lactobacillus-reuteri-reduced-bone-loss-in-older-women/<br /><br />http://mb.cision.com/Main/3271/2393934/753456.pdf<br />Lactobacillus reuteri reduced bone loss in older women<br /><br />However this is a press release, im not sure if this study is funded by biogaia (yes its all about money after all...), if anyone can find the actual study, please forward the link on here.<br /><br />Because the effect on bone are apparantly there that is not to say its effect on the brain can be just as pronounced, time will tell, in the meanwhile im expecting clostridicum butyricum to arrive again, had better success with it compared to reuteri, I will keep you peeps updated.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-48518460560422369702017-11-18T10:49:12.327+01:002017-11-18T10:49:12.327+01:00Hi Petra,
There are indeed lots of cordyceps vend...Hi Petra,<br /><br />There are indeed lots of cordyceps vendors out there and the controversy regarding the quality seems to come from the type of extracts and how they are artificially grown (wild cordyceps costs more than gold per kilogram by the way, this is not a joke).<br /><br />If you look over on reddit/r/nootropics you can find alot of information of people discussing the quality and the vendors being involved and explaining their extraction processes and such.<br /><br />My pick was realmushrooms due to extensive reading on there.<br /><br />Are you taking it early in the day or before bed? before bed it can definatly cause sleep problems, it is best taken in the early morning and my second dose I take at like 3pm.<br /><br />Im not sure wether I need more LTP or not petra, I have problems with overthinking and this prevents me living in the present (inositol and cordyceps help me with this).<br />What I found striking is that a few days ago someone posted (not sure if it was Peter or a reader) about in some forms of autism people are unable to forget certain things, I really recognize myself in this, it is as if some memories are unable to be erased and I feel as if this forms a 'block'.<br /><br />ASD is very weird, high BDNF seems to be common alot, but also some cases of low BDNF.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-7230498103219537642017-11-17T18:44:42.842+01:002017-11-17T18:44:42.842+01:00Hi Aspie,I use fresh freeze dried grown on rice co...Hi Aspie,I use fresh freeze dried grown on rice cordyceps sinesis 500mg fron Terra Nova UK brand product, one I could really quickly get hold of in Greece.<br />Knee joint pains disappeared, back pain diminished, I can control my body movement much better, which started to deteriorate after summer.<br />Behaviourally it's complicated to explain. For example, I usually have an early long deep sleep. With cordyceps I find myself waking up in the early hours a couple of times finding myself overthinking. This is not annoying because I soon after go back to seep again, as if things are being resolved on their own, if this sounds understandable.<br />I think I cannot tolerate more than 500mg every other day, it's nootropic.<br />Aspie let me ask you something I may not have quite well understood, are you looking for something to increase long term potentiation?petra petrahttps://www.blogger.com/profile/04739468164075216419noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-1561063228588963282017-11-17T09:49:13.779+01:002017-11-17T09:49:13.779+01:00By the way peanutoil (pretty sure also peanutbutte...By the way peanutoil (pretty sure also peanutbutter?) is one of the best sources of Arachidic acid (closely related to arachidonic acid but not the same)<br /><br />https://en.wikipedia.org/wiki/Arachidic_acid<br /><br />"ts name derives from the Latin arachis—peanut. It can be formed by the hydrogenation of arachidonic acid."Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-90260410957209032162017-11-17T09:45:39.324+01:002017-11-17T09:45:39.324+01:00Funny that you mention peanutbutter tyler, its the...Funny that you mention peanutbutter tyler, its the food I used to have a strong addiction for it, along with orangejuice, especially when I was socially isolated.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-35508033295417790722017-11-17T05:59:31.145+01:002017-11-17T05:59:31.145+01:00An interesting study on nuts suggests that differe...An interesting study on nuts suggests that different types of nuts have different effects on brainwave activity:<br /><br />Press Release:<br /><br />https://www.sciencedaily.com/releases/2017/11/171115091809.htm<br /><br />Paper:<br /><br />http://www.fasebj.org/content/31/1_Supplement/636.24<br /><br />The general finding was that delta wave power was increased by peanuts (generally high in autism) and gamma wave power was increased by pistachios (low most of the time in autism and thought to be a marker for properly functioning parvalbumin interneurons).<br /><br />Now I just need to get my son to switch from constantly raiding our jars of peanut butter and eat pistachio butter instead.Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-60486151928949565632017-11-16T18:00:42.147+01:002017-11-16T18:00:42.147+01:00Aspie, thanks for the report and for the reminder ...Aspie, thanks for the report and for the reminder - I had stopped a few things when my son’s flare intensified and will add it back in. I was giving in the evening because I had read reports of people commenting on how it helped their sleep. I am glad you are having such s positive response - very encouraging:)Tanyahttps://www.blogger.com/profile/01489962611979985947noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-91387023003029255142017-11-16T16:51:48.482+01:002017-11-16T16:51:48.482+01:00Thanks Petra, I will check his levels soon. I did ...Thanks Petra, I will check his levels soon. I did add a low dose in after your post. His levels have been low in the past. I never realized how much I was confusing just stimulatory behavior due to boredom with real OCD until this recent flare up with my son. I have never seen anything like this from him, and that includes after the first strep infection that resulted in the PANDAS diagnosis when he was 4. Things have gotten a little better since giving frequent antimicrobial dosing and the other supports for infections flares, like treating the "cytokine storm"..Tanyahttps://www.blogger.com/profile/01489962611979985947noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-79202427048572338682017-11-16T16:33:54.645+01:002017-11-16T16:33:54.645+01:00Thankyou Petra, what benefits your son, and Jane´s...Thankyou Petra, what benefits your son, and Jane´s son, will benefit my son.He presents the same obsessions, in his case, as he is only 11, the fear or bad thoughts are to potencial dangers that could happen to him or our family, death in particular and all the details.From some time,he is obsessed with Micahel Jakson and the circumstances of his death.As he adores his music he knows all about him and read that the wrong pill given by his doctor had to do with it, he thinks that the same could happen to him, as he also takes pills.He can´t even watch the lego thriller tribute to MJakson because he has nightmares! I will not risk Uridine for the moment.<br />ValentinaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-87026866604371478982017-11-16T16:04:46.761+01:002017-11-16T16:04:46.761+01:00And thanks you Aspie for the link, I hope that Lys...And thanks you Aspie for the link, I hope that Lysine helps with my son neuronal hyperexcitability, along with glucosamine.ValentinaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-19382985015723813262017-11-16T16:01:19.950+01:002017-11-16T16:01:19.950+01:00Tyler,I am expecting lysine by first days of decem...Tyler,I am expecting lysine by first days of december, along with glucosamine, I expect to wean off valproate and use them instead.Since i give fish oil and citrulline, I could lower valproate to 250 mg a day and all seems really ok.<br />ValentinaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-89198869269681735872017-11-16T15:04:17.042+01:002017-11-16T15:04:17.042+01:00Hi Petra,
I use cdp-choline (250mg) which convert...Hi Petra,<br /><br />I use cdp-choline (250mg) which converts into choline and uridine basically, I wonder why I respond better to cdp-choline than pure UMP (uridine monophosphate).<br />I have got UMP from nootropicsdepot (they test all their products and got a good reputation and consistency), have taken 250mg sublingual in the past a couple of times but it seemed to make me irritable (maybe the dose was too high?), Ive seen posts on reddit about people taking doses as low as 15-30mg.<br /><br />Uridine upregulates dopamine receptors by the way, and oddly enough it is elevated in most cases of autism.<br />Really strange that cdp-choline works better for me than UMP, might have to try UMP in the future again but a very low dose as I still got the small bottle.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-56104740886463485302017-11-16T13:21:22.887+01:002017-11-16T13:21:22.887+01:00Forgot to add, I am still on cordyceps & inosi...Forgot to add, I am still on cordyceps & inositol, they seemed to have reduced my irritability from a scale of 10/10 to 1/10 and I seem more open, I especially notice people reacting different to me (in a positive way).<br />Visiting the doctor this afternoon and going to ask for a new bloodtest to see if my b12 and urea have come down. I will also get vitamin d3 tested, see how much it has dropped in about 2 months.<br />It was around 100 on a scale of 30-130 last time.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-29302090769095671432017-11-16T13:17:31.916+01:002017-11-16T13:17:31.916+01:00Thanks for that Tyler,
I have used it in the past,...Thanks for that Tyler,<br />I have used it in the past, but I was on a lot of other supplements then aswell so it is hard to figure out what is doing what, I only noticed the last 2 days that I used it how effective it is.<br />And as you mentioned it is very cheap especially if you get the powder in bulk, great cost/efficiency ratio this supplement if you ask me, along with taurine.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-27233925033875800502017-11-16T11:27:55.129+01:002017-11-16T11:27:55.129+01:00Valentina, I used Uridine 300mg/capsule from Doubl...Valentina, I used Uridine 300mg/capsule from Double Wood supplements up to 900mg/day. As far as I can remember, it didn't bring any adverse effect and seemed well tolerated.<br />I think it made my son to move a little bit out of his stagnation but I can't say much.<br />When I take 300mg I don't really feel a dopamine rush.<br />For the general population it is supposed to give benefits, for your son's dopamine issues you would have to risk.petra petrahttps://www.blogger.com/profile/04739468164075216419noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-7440662085467202102017-11-16T10:21:26.173+01:002017-11-16T10:21:26.173+01:00Maria, here is the title of the article:
"Vit...Maria, here is the title of the article:<br />"Vitamin D Deficiency in Obsessive–Compulsive Disorder Patients with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infecti: A Case Control Study"https://www.ncbi.nlm.nih.gov/pubmed/28360763 -petra petrahttps://www.blogger.com/profile/04739468164075216419noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-20948559072329172202017-11-16T10:05:51.827+01:002017-11-16T10:05:51.827+01:00I give my son L-Lysine to help boost GABAergic act...I give my son L-Lysine to help boost GABAergic activity basically for the reasons you mention. The idea I got from reading drug user forums (I don't use illicit drugs myself, but people have a lot of creative ideas in dealing with addiction that are too taboo to find on a site like WebMD.com) and one idea that came up with evidence to back it up was to use L-Lysine as a benzo booster (these were primarily people trying to handle their addiction to benzos that their doctor/psychiatrist prescribed them). So the idea they had was to reduce their benzo dosage by boosting its efficacy using L-Lysine. I want to boost GABA signaling in my son, but not with large doses of benzos which are addictive, build up tolerance rapibly, and have lots of negative side effects including permanently reduced cognition (yet doctors in the USA still routinely prescribe these in high doses for anxiety and other maladies in spite of the evidence of long-term damage in doing so). You can find my comments on L-Lysine a year or so back on this blog by searching for them.<br /><br />L-Lysine is also cheap and even though you can get plenty of it via diet (it is also non-essential) I didn't see it as an intervention with any discernable health risk. Good GABAergic interventions in autism are far and few between not only for the reasons mentioned above, but because of the wide variety of GABAergic interneurons in the brain that do many different things and have varying concentrations in different parts of the brain.Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-87854280710385314292017-11-16T00:30:30.234+01:002017-11-16T00:30:30.234+01:00Hi Aspie,
Thanks for your insights as always!
I ...Hi Aspie,<br /><br />Thanks for your insights as always!<br /><br />I actually have some Clostridium Butyrate in one of the probiotics I'm giving my daughter right now during her antibiotic / anti-yeast protocol. <br /><br />I'm hoping that we get rid of the bad bugs / yeast, replace with good bugs (including C butyrate)and S. boulardii, and also supplement with some sodium butyrate.<br /><br />I am thinking about using piperine with the sodium butyrate to increase bioavailability.<br /><br />Any thoughts (Aspie or others)?<br /><br />AJ Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-81802025687700126082017-11-15T22:37:06.208+01:002017-11-15T22:37:06.208+01:00Tanya,
Was it you that was giving your son the ly...Tanya,<br /><br />Was it you that was giving your son the lysine?<br /><br />I started lysine myself since yesterday, took 1000mg on an empty stomach last night and noticed I started yawning alot and it felt like it helped me give better sleep, now today I took 1000mg between lunch and dinner and noticed the anti-anxiety effects (seems to help with overthinking), now tonight I took another 1000mg and started yawning again, seems like a good sleep aid to me.<br />Considering I have had tons of sleep issues in the past (and to be honest my sleep is still not optimal but greatly improved) this is very nice.<br />I wonder what its mechanism would be, it lowers serotonin levels but this study also suggest anticonvulsant like activity:<br /><br />L-lysine is a barbiturate-like anticonvulsant and modulator of the benzodiazepine receptor.<br />https://www.ncbi.nlm.nih.gov/pubmed/8587651<br /><br />"The convulsant benzodiazepine Ro5-3663 dose-dependently inhibited the enhancement of [3H]FTZ binding by L-lysine. This article shows the basic amino acid L-lysine to have a central nervous system depressant characteristics with an anti-PTZ seizure activity and an enhancement of [3H]FTZ binding similar to that of barbiturates but different from GABA."<br /><br />It feels as a 'natural' sleep remedy in that it does simply knock me out, but gradually makes me sleepier (I have used temazepam and zolpidem in the past and these just knock me out), lysine works very different on me, even compared to 5htp (supplement).<br />I feel as it just makes me relaxed, allowing me to surrender to go sleep so to speak.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-35521449804940103222017-11-15T15:39:22.592+01:002017-11-15T15:39:22.592+01:00Roger, that is a mammoth book.
If you want to hea...Roger, that is a mammoth book.<br /><br />If you want to hear Uta Frith, who comes up in all books on autism. There is a podcast below.<br /><br />I think she feels a little guilty for promoting this ever widening Autistic Spectrum and understands that the "original" autism is now getting overlooked, in favour of the new fashionable quirky autism. <br /><br />https://www.tes.com/news/school-news/breaking-views/listen-what-every-teacher-needs-know-about-autism-professor-utaPeter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-25185207508692158862017-11-15T11:59:16.634+01:002017-11-15T11:59:16.634+01:00No problem AJ,
I got sodium butyrate here at home...No problem AJ,<br /><br />I got sodium butyrate here at home, I find it activating by the way (600mg on empty stomach), apparantly the oxytocin like effect comes with chronic dosing.<br /><br />However a problem with sodium butyrate seems to be bioavailability in humans, clostridicum butyrate might be a better option by introducing this probiotic endogenous production of butyrate enhances.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-12061439035230439352017-11-15T09:14:17.938+01:002017-11-15T09:14:17.938+01:00I believe Peter had a lengthy discussion about Uri...I believe Peter had a lengthy discussion about Uridine a year or so ago that mostly delved into whether lowering or raising uric acid levels is beneficial for autism. I don't think Uridine is risky and whether it is good or bad for your son will just require trying it or not. My guess is it would be neutral, especially with regards to dopamine because it does not increase extracellular dopamine in the brain, rather it only increases intracellular dopamine released across synapses. My guess here is that its exact effects on dopamine receptors are very receptor specific but I have nothing to back that up.<br /><br />I used to supplement inosine in my son which raises uric acid levels.Tylernoreply@blogger.com