tag:blogger.com,1999:blog-655962722302095847.post2069747637981073757..comments2024-03-27T20:20:54.505+01:00Comments on Epiphany: Clonazepam Dosage and Effectiveness in AutismPeter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger83125tag:blogger.com,1999:blog-655962722302095847.post-78028255290205148302024-02-15T18:51:20.939+01:002024-02-15T18:51:20.939+01:00That is great news.
Amantadine blocks the effects...That is great news.<br /><br />Amantadine blocks the effects of glutamate and so may help with hyperactivity and irritability. You normally start with a low dose of 25mg and then every 5 days increase by 25mg. You observe the effect and stop increasing the dose when the effect is see. A typical dose is 100mg and it is best to stay at that dose or a lower one.<br /><br />This is another therapy that will work well for some and not benefit others. It does have clinical trials to support its use.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-62979678899101528262024-02-15T18:31:36.481+01:002024-02-15T18:31:36.481+01:00Hi Peter we had success with clonazepan it work we...Hi Peter we had success with clonazepan it work well on my son mood and hyperactivity now i would like to try amantadine do yuo think 100 mg a day is ok this is the dose that dr o'hara use i read that yuo use 0.7 my son <br />Has 14 years old.Diegohttps://www.blogger.com/profile/09095923106613437663noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-76707253208724254722024-01-23T14:53:05.604+01:002024-01-23T14:53:05.604+01:00According to the producer one drop of your drug co...According to the producer one drop of your drug contains 0.1 mg. I think you would need 0.03 to 0.04 mg. So you would need another bottle and make a weaker solution using water. If you add one drop of clonazapam to 9 drops of water you will have 0.01mg per drop. <br /><br />You will need a syringe to measure things.<br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-912006472298302962024-01-23T14:14:04.586+01:002024-01-23T14:14:04.586+01:00Hi Peter if I take rivotril 2.5 mg /ml according t...Hi Peter if I take rivotril 2.5 mg /ml according to my calculations 1ml is 25 drops so one drop will be 0.04 mg can I and is this right? Can I try this dose for him who is 14 years old and weighs 59 kg?Diegohttps://www.blogger.com/profile/09095923106613437663noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-24483151608379414662022-10-04T20:05:35.130+02:002022-10-04T20:05:35.130+02:00Dr Nk,
Note that lower carb diets are sometimes he...Dr Nk,<br />Note that lower carb diets are sometimes helpful for epilepsy. Sometimes it doesn't have to be the full keto (no carb) version, so perhaps reducing sugars and starches in the diet will help (try searching for "Modified Atkins Diet").<br />Note: I am not a doctor, and don't know if there are any studies with this particular kind of epilepsy, so this is just a suggestion / idea for research.<br /><br />Aspie2Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-32873577370968632042022-05-19T04:28:34.134+02:002022-05-19T04:28:34.134+02:00Hi Peter, kindly accept my gratitude and thanks. I...Hi Peter, kindly accept my gratitude and thanks. I finally see a ray of hope in this dark Dungun of autism. Your blogs have given so much that it simply cannot be expressed in words. I live in Toronto let me if I could be of any help. My son's story some other time.<br /><br />Regards<br />PeeraniAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-14381928138563184222022-05-18T15:39:07.831+02:002022-05-18T15:39:07.831+02:00Hello, we give him 15gr twice a day, and after 2 h...Hello, we give him 15gr twice a day, and after 2 hours Allergoval 4 capsules a day divided into 2 doses, my boy is 18 years old and 95 kg, now you can see how you dose it ....BUGA DRAGOSnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-41559936539936135252022-05-17T14:23:37.885+02:002022-05-17T14:23:37.885+02:00Hello Dragos,
I'm happy to read that you'v...Hello Dragos,<br />I'm happy to read that you've found a working solution. May I ask if you are using the recommended doses of Enterosgel or a bit more? I want to give it a try for my 5.5 year old son. The package says for kids 1-6 years old, the recommended dose is 5 g x 3 times a day. Are you giving 15-20 g in total a day or it's just a single dose?<br /><br />Thanks in advance,<br />OktayAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-41219075081215790272022-05-09T10:59:04.156+02:002022-05-09T10:59:04.156+02:00Peter, Denis has had bowel problems since he was a...Peter, Denis has had bowel problems since he was a year old, then he had soft and frequent stools, practically everything he ate did not have time to digest, now we face constipation and food selection, but since we use allergoval (cromolyn) and enterosgel, constipation is gone. This gel is a miracle for us, I think it detoxifies aluminum from the MMR vaccine, or other toxins.I think a major problem is the damaged intestine, and the enterosgel comes and repairs.<br />Galavit we couldn't buy the problem anymore (Putin), but thanks to the Australian for the article, Enterosgel I think is much better than what they are trying to make now, thanks to the Russians for making it.BUGA DRAGOSnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-35489648711557600622022-05-09T10:14:32.282+02:002022-05-09T10:14:32.282+02:00Hi Dragos, that is very interesting. There is a n...Hi Dragos, that is very interesting. There is a new drug (AB 2004) in the research that also targets harmful substances that are produced by gut bacteria, so the idea makes good sense.<br /><br />https://www.axialtx.com/newsfeed/nature-medicine-publishes-full-results-from-axial-therapeutics%E2%80%99-phase-1b%2F2a-clinical-trial-in-autism-spectrum-disorder-(asd)<br /><br /><br />For other readers, here is a link to the Enterosgel product.<br /><br />https://enterosgel.eu/?l=en&m=co-je-to-enterosgel<br /><br />Does Stefan have intestinal problems? <br /><br />In the drug trial I mentioned above they target people with autism + intestinal problems + anxiety. Their therapy is supposed to cure the anxiety, but only for those with GI problems.<br /><br />Are you still wanting to use Galavit? or is it no longer needed?<br /><br />Enterosgel looks well worth a try for those with autism + autoimmune issues.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-15634185753272473272022-05-08T21:11:09.090+02:002022-05-08T21:11:09.090+02:00
Hi Peter, I think I found a magic formula for my ...<br />Hi Peter, I think I found a magic formula for my son Denis-Stefan, I would like to make it known to help these children with this autoimmune encephalitis. The formula is: cromolyn sodium (allergoval) 4-6 capsules a day, and surprise is enterosgel 15 -20mg 2-3 times a day (in 20 minutes after administration he started to draw and look at magazines, the agitation disappeared, he is very calm, he watches TV and he seems to understand what is being discussed, no you still need verapamil, you stay out for hours, it is a permanent improvement every day, your sleep has improved, you sleep very well, in the morning you are lazy in bed like we adults do, you are no longer alone in the room) 2.5 mg prozac in the morning , and in the evening at bedtime 10 mg bacoflen.<br />The allergy on the face is gone, she has a clean complexion now, 80% improvement is from this intestinal absorbent, it worked wonders for usBUGA DRAGOSnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-89765229029331753642022-05-08T18:57:06.022+02:002022-05-08T18:57:06.022+02:00I suggest you lower the dose by 20%I suggest you lower the dose by 20%Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-30818821651159625702022-05-08T18:15:32.254+02:002022-05-08T18:15:32.254+02:00Yea we notice more adamant, aggressive Yea we notice more adamant, aggressive Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-64911137607046685422022-05-08T06:32:55.265+02:002022-05-08T06:32:55.265+02:00More responsive. No increased aggressiion or negat...More responsive. No increased aggressiion or negative behaviours<br /><br />But late to sleep is obvious Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-5968727155737989852022-05-07T20:48:05.656+02:002022-05-07T20:48:05.656+02:00What are the positive effects that you are seeing?...What are the positive effects that you are seeing?<br />Is there any aggression or other negative behaviors?<br /><br /><br /><br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-17788629376061914982022-05-07T20:41:28.121+02:002022-05-07T20:41:28.121+02:00Hi Peter
clonazepam 25mcg
seems to work for son...Hi Peter <br />clonazepam 25mcg <br /> seems to work for son but he just don't want to sleep. But not hyper <br /><br />Do you think dose is too low or highAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-21937574361471233322020-12-21T12:11:44.326+01:002020-12-21T12:11:44.326+01:00Aggression has always been a problem with my son a...Aggression has always been a problem with my son and BCAA therapy may help with respect to autism as I believe most of the aggression is due to excess dopaminergic signaling in both the dorsal striatum and ventral striatum (brain areas). The same area of the brain that dies off in Parkinson's disease supplies the dopamine to these other areas in well-regulated loops. You could have a situation via improper brain development where you have excessive dopamine sensitivity of D1 or D2 like receptors which Risperidone blocks, or else just too much dopamine via these loops called the mesolimbic dopamine loop and the nigrostriatal loop. There are three main pathways in what is called the basal ganglia of which the striatum is part of which affects motor, cognitive, and limbic (mood and reward) output and acts like a pedal and a break for behaviors and those are the direct, indirect, and hyperdirect pathways. The direct pathway is like the gas and the indirect pathway is like the brake and the hyperdirect pathway is like the emergency brake. Dopamine stimulates D1 receptors which drive the direct pathway (the gas) as well as D2 receptors which inhibit the indirect pathway (the brake). So dopamine causes you to hit the gas on the car and take off the break at the same time and too much dopaminergic signaling will cause the car to always be driving really fast with no way to stop (which can mean not being able to calm down).<br /><br />So to deal with excess dopamine, I have used BCAA therapy as well as a few other readers on this blog with some anecdotal success. You can search the forum for my posts for the exact methodology of it all if you wish. It is a cheap therapy which may help with some of the worst of the aggression if excess dopamine is the problem. Risperidone by the way goes after the D2 receptor and eventually leads to tolerance and an imbalance in the basal ganglia pathways leading to tardive dyskinesia as well as problems with D3 receptor stimulation in a part of the hypothalamus that regulates the release of prolactin which will grow breasts.<br />Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-77215507747041026072020-12-21T00:29:05.429+01:002020-12-21T00:29:05.429+01:00Thank you for the answer. The tics appeared during...Thank you for the answer. The tics appeared during Rispolept treatment. The problem is that in my country few is known about autism and adhd. All the information parents have to struggle alone to find. Great thanks to internet and persons like you, that share information with us.Anonymoushttps://www.blogger.com/profile/09321631573505447050noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-63474257473894341302020-12-20T10:32:36.167+01:002020-12-20T10:32:36.167+01:00Rispolept/Risperidone increases the amount of dopa...Rispolept/Risperidone increases the amount of dopamine (by the serotonin 5-HT2A blocking effect in the presynaptic receptor) and may causes tics and other features of what is called tardive dyskinesia. This is a very common side effect. It is reported to affect 25+% within a year.<br /><br />Tardive dyskinesia can be difficult to make go away. Do not take Rispolept/Risperidone ever again. It can become permanent.<br /><br />If you already have tics, like in Tourette syndrome, Risperidone can actually make them go away.<br /><br />Low dose Rivotril is cognitive enhancing, it will not reduce aggression. At this very low dose it is non addictive and so you take it for as long as it provides the cognitive effect (i.e. for years and years).<br /><br />For aggression you have to find the underlying reason, and then treat that. There are very many possible causes and very many associated therapies.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-75034464704500107422020-12-19T22:43:26.139+01:002020-12-19T22:43:26.139+01:00Hello, tell me please, how long can I give low dos...Hello, tell me please, how long can I give low dose Rivotril? My son is 11 and is very aggressive. Rispolept didn't help, now he has tics.Anonymoushttps://www.blogger.com/profile/09321631573505447050noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-10995296546763185692020-11-25T09:40:25.402+01:002020-11-25T09:40:25.402+01:00Nk treating your son's epilepsy effectively is...Nk treating your son's epilepsy effectively is very important and for this you need a good neurologist.<br /><br />You also asked in another comment about fish oil and cbd oil in epilepsy and autism. Some people do find certain types of fish oil helpful in autism. Fish oil contains EPA and DHA, and the effect will vary between how much EPA and how much DHA is contained. You could read about the use of EPA/DHA in attention deficit hyperactivity disorder (ADHD). High EPA fish oil increases NAA (N-acetylaspartate) which should be helpful, so I would try high EPA fish oil. <br /><br />I would ask your neurologist about CBD oil. <br /><br />If you want to treat your son's autism the best place to start is a trial of bumetanide. Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-15826061363626278692020-11-24T21:19:33.020+01:002020-11-24T21:19:33.020+01:00Hello, my son is 4 years old asd, with silent epi...Hello, my son is 4 years old asd, with silent epilepsy , during sleep, 17kg, he is on topiramate 25+0+15mg, lacosamide 3.5+0+3.5mg<br />But he is getting hyper, laughing spells, alot of verbal stimming , also fits are not under control, kindly guide me, can i start revotril drops with these medications for my sonDr. Nkhttps://www.blogger.com/profile/17301357291458657439noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-40336575579768357632020-08-26T14:13:36.567+02:002020-08-26T14:13:36.567+02:00Well spotted ! Another benefit of making more eNOS...Well spotted ! Another benefit of making more eNOS.<br /><br />Agmatine inhibits matrix metalloproteinase-9 via endothelial nitric oxide synthase in cerebral endothelial cells<br />https://www.researchgate.net/publication/6249707_Agmatine_inhibits_matrix_metalloproteinase-9_via_endothelial_nitric_oxide_synthase_in_cerebral_endothelial_cells<br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-59314256320621244812020-08-26T10:58:42.071+02:002020-08-26T10:58:42.071+02:00An MMP9 inhibitor is already in the polypill in th...An MMP9 inhibitor is already in the polypill in the form of Agmatine. https://pubmed.ncbi.nlm.nih.gov/17588309/Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-28462160366803392852020-08-14T03:32:24.919+02:002020-08-14T03:32:24.919+02:00As someone that has been tormented by sensory issu...As someone that has been tormented by sensory issues and low levels of serotonin klonopin gave me a beautiful and authentic take on life that was only available in glimpses when i was taking no meds. Before taking this medication i was going thru life trying to control every sensory possible and this need to control sensory ruined alot of relationships on my life as I could not process regular emotions necessary to decelope meaningful relationships without having an overload or shutdown. Its worth noting that b4 i had tmj from my constant stress response to stimuli, klonopin gave me the option to observe my situation from afar and cope with stress in healthy manners.Anonymoushttps://www.blogger.com/profile/04473153600727188570noreply@blogger.com