tag:blogger.com,1999:blog-655962722302095847.post1922549211718619377..comments2024-03-29T10:24:53.156+01:00Comments on Epiphany: Buy Arbaclofen for Autism? Perhaps try Pantogam Aktiv?Peter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger38125tag:blogger.com,1999:blog-655962722302095847.post-75531590991604299932021-08-29T16:25:23.532+02:002021-08-29T16:25:23.532+02:00Thank you very much Peter, I wanted to buy arbaclo...Thank you very much Peter, I wanted to buy arbaclofen but it's not possible here, I'll try with baclofen or pantogam, just to check if he's one responder.GKnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-78683740436597674262021-08-29T13:48:13.300+02:002021-08-29T13:48:13.300+02:00GK, some people have reported that the benefit of ...GK, some people have reported that the benefit of Pantogam fades and so it is not good to take long term, but in Russia it is used long term. Since you live in Spain you may be able to buy Baclofen, which works well for some Aspies. The two drugd work via GABAb receptors.<br /><br />I do not think you have a problem combining with bumetanide.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-40712179692739658902021-08-29T10:43:03.248+02:002021-08-29T10:43:03.248+02:00Dear Peter,
I have a son with Asperger syndrome an...Dear Peter,<br />I have a son with Asperger syndrome and ADHD, we live in Spain. He's 8 years old and we started bumetanide 6 months ago. With this medication he has less oppositional behavior and our quality of life is better. I ordered pantogam activ and I'd like to try it but I'm doubting if continuos with the bumetanide, as well.<br />I'd appreciate your opinion.GKnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-55553324823261156672020-04-21T15:07:01.154+02:002020-04-21T15:07:01.154+02:00Please which success did you gain on pantogamPlease which success did you gain on pantogamAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-82917075100659260382020-01-28T08:55:26.888+01:002020-01-28T08:55:26.888+01:00Hi, how much of pantogam did you give to your chil...Hi, how much of pantogam did you give to your child on daily basis, there is no instruction for dosage for autism specifically, did you use liquid form? We had also success with it, but I gave my kid just for 3 months, as instruction, I see here I could administer pantogam for longer 6 months maybe?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-73569277346167404592019-07-30T07:40:02.206+02:002019-07-30T07:40:02.206+02:00This comment has been removed by the author.Denisahttps://www.blogger.com/profile/14964354258191179489noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-5966601420116659612019-07-30T07:39:11.478+02:002019-07-30T07:39:11.478+02:00This comment has been removed by the author.Denisahttps://www.blogger.com/profile/14964354258191179489noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-78679575363796193172019-03-07T18:59:49.875+01:002019-03-07T18:59:49.875+01:00Good to know that Pantogam was so effective.Good to know that Pantogam was so effective.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-44060013113352059142019-03-07T15:20:52.332+01:002019-03-07T15:20:52.332+01:00Thank you for your article! My child was diagnosed...Thank you for your article! My child was diagnosed with very mild form of autism (speech delay was one of the symptoms) and suspicion of ADHD. She was prescribed Pantogam (by a Russian doctor, as we are originally from Russia but live in the US). I can tell you that I started seeing results after three weeks. Prior to Pantogam she was unable to concentrate on anything, I could not read books to her, she didn't want to talk (or I'd rather say she could not speak). Three weeks later I noted that she started talking more, her attention span got so much better! Even teachers at pre-K noticed that. Her fine motor skills improved in just 1 month! Prior to that she couldn't even hold pencil properly, not speaking about drawing, coloring, etc. She took Pantogam for 5 months. I can tell with certainty that there were significant improvements both in speech, fine motor skills, behavior, understanding of various concepts. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-5279251928261652832018-11-18T22:02:50.628+01:002018-11-18T22:02:50.628+01:00Ehmmmm.... thoughts on this? Kinda puts me off tbh...Ehmmmm.... thoughts on this? Kinda puts me off tbh:<br /><br />Acute encephalopathy with hepatic steatosis induced by pantothenic acid antagonist, calcium hopantenate, in dogs<br />https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0676.1991.tb00506.x<br /><br />Note the study also talks about side effect in a human, not just dogs.<br /><br />Also for thos wondering, calcium hopantenate = pantogam!, its the same. And I find it shocking that its a vitamin b5 antagonists.<br />Which makes me think Peter you are overlooking a dramatic thing, namely, vitamin b5 is strongly implicated in not just the TCA cycle, but also ACETYLCHOLINE synthesis, this makes me think that pantogam is 'sedative/calming' by inducing a choline deficiency. This would also explain the possible benefits it can have in high functioning autism, by point blank shooting choline out of the system cognition is gone and similar to how a hangover or sleep deprivation can have antidepressant effect by low choline in the brain, HELLO delerium.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-26674401801149947892018-11-18T20:46:48.389+01:002018-11-18T20:46:48.389+01:00Mebicar
Mebicar (mebicarum) is an anxiolytic medi...Mebicar<br /><br />Mebicar (mebicarum) is an anxiolytic medication produced by Latvian pharmaceutical company Olainfarm and sold in Latvia and Russia under the brand name Adaptol.[2] Mebicar is not approved for use in the United States.<br /><br />Mebicar has an effect on the structure of limbic-reticular activity, particularly on hypothalamus emotional zone, as well as on all 4 basic neuromediator systems – γ aminobutyric acid (GABA), choline, serotonin and adrenergic activity. Mebicar decreases the brain noradrenaline level, exerts no effect on the dopaminergic systems, increases the brain serotonin level, and does not elicit cholinolytic action.[3]<br /><br />Mebicar purportedly has anti-anxiety (anxiolytic) properties.[3][4][5][6][7] It is also used to aid smoking cessation.[2] In addition, mebicar may be useful in the treatment of ADHD symptoms.[8] In contrast with typical anxiolytic medications such as benzodiazepines, mebicar is non-habit forming, non-sedating and does not impair motor function.[4][2]<br /><br /><br />Tofisopam (pde4 and pde10 manipulation)<br /><br />Tofisopam[1] (Emandaxin, Grandaxin, Sériel) is an anxiolytic that is marketed in several European countries.[2] Chemically, it is a 2,3-benzodiazepine. Unlike other anxiolytic benzodiazepines (which are generally 1,4- or 1,5-substituted) however, tofisopam does not have anticonvulsant, sedative,[3] skeletal muscle relaxant, motor skill-impairing or amnestic[4] properties. While it may not be an anticonvulsant in and of itself, it has been shown to enhance the anticonvulsant action of classical 1,4-benzodiazepines (such as diazepam) and muscimol, but not sodium valproate, carbamazepine, phenobarbital, or phenytoin.[5][6] Tofisopam is indicated for the treatment of anxiety and alcohol withdrawal, and is prescribed in a dosage of 50–300 mg per day divided into three doses. Peak plasma levels are attained two hours after an oral dose. Tofisopam is not reported as causing dependence to the same extent as other benzodiazepines, but is still recommended to be prescribed for a maximum of 12 weeks.<br /><br />Tofisopam is not approved for sale in the United States or Canada. However, Vela Pharmaceuticals of New Jersey is developing the D-enantiomer (dextofisopam) as a treatment for irritable bowel syndrome,[7] with moderate efficacy demonstrated in clinical trials so far.[8]<br /><br />Tofisopam is also claimed to be a PDE10A inhibitor, which may provide an alternative mechanism of action for its various therapeutic effects, and this action has been proposed to make tofisopam potentially useful as a treatment for schizophrenia.[9]<br /><br />Tofisopam has been shown to act as an inhibitor of the liver enzyme CYP3A4,[10] and this could cause dangerous drug interactions with other medications metabolised by this enzyme,[11][12] although the clinical significance of these findings remains unclear.<br /><br />Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-47725926111687853832018-11-18T20:44:11.849+01:002018-11-18T20:44:11.849+01:00Peter have you seen Tenoten before?
Elevated plas...Peter have you seen Tenoten before?<br /><br />Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders.<br />https://www.ncbi.nlm.nih.gov/pubmed/28099628<br /><br />Clinical Trial of Efficacy and Safety of Tenoten for Children in the Treatment of Specific Developmental Disorders of Scholastic Skills in Children<br />https://clinicaltrials.gov/ct2/show/NCT03159104<br /><br />Tenoten in the therapy of patients with moderate cognitive impairment.<br />https://www.ncbi.nlm.nih.gov/pubmed/20027370<br /><br />"Tenoten is a new anxiolytic and antidepressant based on antibodies to brain-specific protein S-100B. Experimental studies demonstrated the effect of tenoten on mechanisms of neuronal plasticity and manifestations of higher nervous activity. Tenoten is clinically comparable with amitryptiline, sertraline, and phenazepam, but does not produce potent sedative relaxation effect typical of these drugs. The study demonstrated considerable improvement of the control over brain frontal compartment effector functions. Tenoten is recommended not only at the stage of moderate cognitive impairment, but also in manifest cerebrovascular pathologies characterized by pronounced impairment of the regulatory functions of the frontal compartments of the brain."<br /><br /><br />Tenoten again:<br /><br />https://topbrainboosters.com/tenoten/<br /><br /><br /><br />"Tenoten is a novel homeopathic anxiolytic with mild nootropic and antidepressant activity. The active ingredient is antibodies to brain-specific protein S100 that is expressed and secreted by astrocytes and microglial cells.<br /><br />Tenoten acts as anxiolytic by interacting with GABA-A receptors and the opening of a chloride ion-selective channels. The drug modulates synaptic plasticity and increases brain resistance to hypoxia. It also improves cerebral blood flow, thus having some impact on cognition.<br /><br />The studies of the impact of S100 protein and its antibodies on the nervous system began in the 1960’s. During these researches, it was found that the low dosages of S100 antibodies can be used for the treatment of certain dependencies. And in 2001 the new drug was released – ProProTen 100.<br /><br />Proproten marketed as a remedy for hangover relief, and the treatment for alcohol dependence. One of the claimed effects is reducing the urge to drink alcohol. "Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-3256422221206575922018-11-18T20:39:15.421+01:002018-11-18T20:39:15.421+01:00Hi,
Not sure if your still reading this but do you...Hi,<br />Not sure if your still reading this but do you find it is still effective?<br /><br />Also @Peter, I have tried baclofen once, it was only 2 or 5mg, very very small dose but I had a drastic response to it, made me cry A LOT and overly emotional, also it seems to be heavy sedative and at the same time dramatically improve locomotion.<br />As you might have guessed im interested in pantogram... Also considering I have a disproportionally large frame (chest and armspan are insane). I checked my 23andme and I have some problem with IGFB1 or IGFB3 it was I believe, these are insulin growth factor binding hormones, without a doubt I have lots of them by the looks of my frame, which obviously makes me draw the following conclusion: paravalbumin/somastatin disbalance. Another clue for me to this this is: year long high prolactin and high tsh levels, as you might know somastatin is a PRL inhibiting factor and also a growth hormone inhibiting factor.<br /><br />Also from reading somastatin/paravalbumin plays a huge role in emotions through fear conditioning and such in the amygdala.<br /><br />While Im about to start donepezil (my psych is coming back from holiday tomorrow!), shitty thing is Ill have to wean off on gbe761 (ginkgo), Im doing so well on 2x 120mg daily, especially my anhedonia seems very much improved.<br /><br />All in all, russian drugs seem amazing.<br /><br />Bemitil also looks incredibly interesting to me: has an adenosine like structure and no doubt I will respond to it as I do with cordyceps/cordycepin.<br /><br />Metadoxine (ALDH/ADH inducer): changes dopamine in the striatum (aspergers have increased presynaptic dopamine receptors here), not sure what the outcome of it will be, but inositol (makes me feel very calm) also increases d2 and 5ht2a receptors in the striatum.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-73707307439681874912017-09-25T19:43:44.257+02:002017-09-25T19:43:44.257+02:00Did you try Baclofen, which is the closest Western...Did you try Baclofen, which is the closest Western drug to Pantogam? This seems to work well with many people with Asperger's.<br /><br />What dose of Pantogam do you use and how long to you use it for and then how long a pause do you make?<br /><br />Some people find it stops working after a while, maybe they take too much for long. Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-53965344087145927702017-09-25T17:30:16.747+02:002017-09-25T17:30:16.747+02:00Hello,
I stumled on this article while trying to ...Hello,<br /><br />I stumled on this article while trying to find some information on Pantogam in English.<br />First of all, thank you for the article, it's very interesting.<br /><br />Secondly, I also have a 7 yo son with high functioning autism and he has been taking Pantogam for five years (with breaks, as per instruction).<br /><br />It has been an absolute game changer for us: it helps with his mood, social and life skills, sleep, overall life quality.<br />Every time after we completed a course, we had a break through: he started talking, using the toilet on to playing with his sister and so on. So as a parent, I have a lot of experience with it and am happy to answer any questions you might have.Mmmmmhttps://www.blogger.com/profile/01036804749271608231noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-38425085409081151222017-04-02T19:30:47.904+02:002017-04-02T19:30:47.904+02:00S, you might want to consider the numerous other F...S, you might want to consider the numerous other Fragile-X trials that "failed". Most of these use readily available drugs targeting then same E/I imbalance as Arbaclofen.<br /><br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396424/table/t1-tacg-8-075/Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-84444042419717490052017-04-02T19:09:00.384+02:002017-04-02T19:09:00.384+02:00Arbaclofen is far more potent than baclofen. Panto...Arbaclofen is far more potent than baclofen. Pantogam is in effect the Russian equivalent of Baclofen, targeting GABAb receptors. From the people selling it:- <br /><br />"The general dose is 300-900mg (1-3 capsules) 15-20 minutes after meal 2-3 times per day (preferably in the morning and at day time). Maximum dose is 2400mg (8 capsules)."<br /><br />The whole idea of arbaclofen was to make a super-potent baclofen. So it must have been more potent than the standard dose of baclofen, probably many times more potent.<br /><br />So you might as well compare the standard dose of Pantogam to see how it compares with the standard dose of Baclofen.<br /><br />Incidentally you might want to consider why arbaclofen worked.<br /><br />GABAB-mediated rescue of altered excitatory–inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction<br /><br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410621/<br /><br />It is likely that your son has reduced NMDAR signaling.<br /><br />There are plenty of ways other than Baclofen to treat this. You need to upregulate NMDA receptors.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-71174697819029778452017-04-02T18:29:32.491+02:002017-04-02T18:29:32.491+02:00Also, to answer your first question - when the tri...Also, to answer your first question - when the trial was discontinued, we were given Baclofen to wean him off of Arbaclofen, and while we still noticed great difficulties during the process, we came to the conclusion that the Baclofen was 'better than nothing' regarding his regular meds (sertraline and B vitamins compounded)that he also had to stop while in the first phase of the trial. I have obtained some of the Russian Pantogam Aktiv but have not tried it yet. The dosage is hard for me to calculate as we weren't told the amount of Arbaclofen he was on during the trial, and of course the overall anxiety of treatment without enough medical knowledge regarding chemical compounds and the effects on the brain. If we knew the exact dose he was given during the trial I would be less trepidacious as I am dying to try it, but am afraid to as we saw first hand how one higher dose effected him. Anyone with advice or encouraging words about this dilemma would be greatly appreciated.Shttps://www.blogger.com/profile/13882311866379698063noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-9007254178217022882016-10-28T20:43:35.146+02:002016-10-28T20:43:35.146+02:00Just to note Phenibut and Gabapentin have to be ca...Just to note Phenibut and Gabapentin have to be careful cycled up and down, big withdrawl issues for both if you're not careful.<br /><br />Phenibut is consistently rated one of the most impactful "nootropics" in the community.Emhttps://www.blogger.com/profile/02924636442485818957noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-54053503690859505292016-09-20T14:21:00.996+02:002016-09-20T14:21:00.996+02:00That is interesting. What kind of autism does he ...That is interesting. What kind of autism does he have? Is it more like Asperger's, since you say he is able to work.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-59955346084200811122016-09-20T12:58:04.127+02:002016-09-20T12:58:04.127+02:00My son was involved in the autism R Baclofen studi...My son was involved in the autism R Baclofen studies. He experienced extreme improvement with his life limiting social anxiety issues. He crashed hard when the study was discontinued and returned to being a shut in. We saw more gradual improvement with straight Baclofen, but now he is able to work, shop, and socialize in public. He takes 20 Mg 4 every 6 hours. The only downside is that he begins to experience withdrawal symptoms if a dose is only a few hours late.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-23206825439377482852016-09-08T18:44:33.596+02:002016-09-08T18:44:33.596+02:00Intranasal ketamine is currently being trialled in...Intranasal ketamine is currently being trialled in autism. If you use the "search this blog" function in this blog you can see what I previously wrote about it. Look at the top right of the page.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-19665165999408983142016-09-08T15:22:00.352+02:002016-09-08T15:22:00.352+02:00Has anyone looked into or know of using ketamine i...Has anyone looked into or know of using ketamine infusions to decrease glutamate for ASD? Perhaps even in combination with Baclofen?Initia Novahttp://myinitianova.comnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-1577866871189951792016-07-20T14:00:22.464+02:002016-07-20T14:00:22.464+02:00There is also CGP7930, Gaba b receptor agonist, a ...There is also CGP7930, Gaba b receptor agonist, a positive allosteric modulator, being tested with promising results for its anxiolytic, antidepressant effect and also possibly effective for tinnitus and addiction. It doesn't have the adverse side effects of baclofen. Maybe helpful for Asperger's anxiety?Anonymoushttps://www.blogger.com/profile/16138974464162606874noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-86383774311439092072016-07-19T22:59:07.049+02:002016-07-19T22:59:07.049+02:00He improved dramatically. Cognitively,it removed a...He improved dramatically. Cognitively,it removed a great deal of anxiety thought by some to be the major stumbling block to learning difficulties regarding those with FXS. Once, we accidently changed his dose while in the trial to a higher dose. This brought on extreme aggravation, but once I located the error, I was able to calm him by explaining the dosage error and the time it would take for it to diminish. It was completely understood. I am highly aware of the placeobo effect- even the difficulties from a truthfully unbiased parent- which is one of the reasons it was not approved. However, considering it is now of interest again, this time by another pharmaceutical company, gives me doubts to the real reason it wasn't approved in Seaside's trial.Shttps://www.blogger.com/profile/13882311866379698063noreply@blogger.com