tag:blogger.com,1999:blog-655962722302095847.post1882634470169804219..comments2024-03-19T08:26:10.761+01:00Comments on Epiphany: “Type 3” Diabetes in Alzheimer’s, but maybe also in some AutismPeter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger23125tag:blogger.com,1999:blog-655962722302095847.post-4535476334891976642023-03-15T14:46:56.469+01:002023-03-15T14:46:56.469+01:00Peter, my son is 8, with intellectual disability/s...Peter, my son is 8, with intellectual disability/severe autism. His dad has Type 1 diabetes; his paternal aunt also has both Type 1 diabetes and a severely autistic child. His dad’s four other siblings do not have diabetes, and they have typically developing children. Do you think there is a link to severe autism/intellectual disability and Type 1 diabetes? In terms of increasing cognition, would sytrinol or verapamil be appropriate, or a different type of statin? My son currently takes leucovorin 75 mg/day, which has helped his speech. I’ve tried to get several doctors to prescribe Bumetanide but they won’t, so my next step is finding a MAPS doctor in the US. In the meantime I would like to try anything that could possibly boost my son’s intellectual functioning. Thank you Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-89876886320866037862019-05-23T22:54:09.573+02:002019-05-23T22:54:09.573+02:00Suzic
Taking vitamin D, omega 3 and excluding glu...Suzic<br /><br />Taking vitamin D, omega 3 and excluding gluten from the diet are also strategies that have been shown to reduce progression of Type 1 DM.<br /><br />https://www.ncbi.nlm.nih.gov/pubmed/29424911/<br /><br />https://www.ncbi.nlm.nih.gov/pubmed/22729336/<br /><br />https://www.frontiersin.org/articles/10.3389/fendo.2019.00101/full<br /><br />Best wishes<br />MashhoodMashhoodhttps://www.blogger.com/profile/04970664210850018220noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-5237760636207587072019-05-23T10:49:39.953+02:002019-05-23T10:49:39.953+02:00Suzic, there definitely are links between insulin ...Suzic, there definitely are links between insulin and autism, I suggest you read up about IGF1.<br /><br />More importantly you may have a chance to prevent your son's progression into becoming fully insulin dependent. I have written about this several times in this blog, but there is a very recent paper which I suggest you read, print out and take to your doctor.<br /><br />In short, as long as your son has beta cells alive in his pancreas he can make insulin. In Type 1 diabetes these beta cells die. In your son many are still alive. A cheap safe calcium channel drug has been shown to block the process b which the beta cells die. That means if given in time you can save the beta cells and that would be great news.<br /><br />You would have to act now and not wait till he is fully dependent on insulin injections. Then it would be too late.<br /><br />Verapamil and beta cell function in adults with recent-onset type 1 diabetes<br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092963/<br /><br />Pancreatic beta cell loss is a key factor in the pathogenesis of type 1 diabetes (T1D), but therapies to halt this process are lacking. We previously reported that the approved anti-hypertensive calcium channel blocker verapamil, by decreasing the expression of thioredoxin-interacting protein, promotes the survival of insulin-producing beta cells and reverses diabetes in mouse models1. To translate these findings into humans, we have conducted a randomized, double-blind, placebo-controlled Phase 2 clinical trial (NCT02372253) to assess the efficacy and safety of oral verapamil added for 12 months to a standard insulin regimen in adult subjects with recent-onset T1D. Verapamil treatment was well tolerated and associated with improved mixed meal-stimulated C-peptide area under the curve as a measure of endogenous beta cell function at 3 and 12 months compared to placebo (pre-specified primary endpoint) as well as with a lower increase in insulin requirements, fewer hypoglycemic events and on target glycemic control (secondary endpoints). Thus, addition of once daily oral verapamil may provide a safe and effective novel approach, to promote endogenous beta cell function and reduce insulin requirements and hypoglycemic episodes in adult individuals with recent-onset T1D.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-48882614498508732742019-05-23T00:07:33.986+02:002019-05-23T00:07:33.986+02:00Interesting. My 13 year old has Autism, ADHD and s...Interesting. My 13 year old has Autism, ADHD and since last year Type 1 diabetes. He does not seem to need much insulin though. Recently we have seen peak in challenging behaviour and are trying to see if it is diabetes linked. suzichttps://www.blogger.com/profile/11824474611035700271noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-8166474339704369392016-04-23T20:35:02.017+02:002016-04-23T20:35:02.017+02:00I would try experimenting, maybe two days with and...I would try experimenting, maybe two days with and then two days without. We see the same result, with the effect fading. Using higher and higher doses is not a good idea.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-83937615290778991612016-04-23T06:42:39.445+02:002016-04-23T06:42:39.445+02:00So the effect has waned quite a bit ... After the ...So the effect has waned quite a bit ... After the initial excitement with all of his babbling ... It has tapered off almost back to where we were originally ... Would you suggest increasing sytrinol to two pills a day ? Or perhaps every other day? Or move on try something else:( so discouraged. Unknownhttps://www.blogger.com/profile/07290276102260430780noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-67434680923907467042016-04-07T11:27:23.179+02:002016-04-07T11:27:23.179+02:00I think the only way is to buy some and try it. As...I think the only way is to buy some and try it. As you can see in the comment above from the mother whose son is now saying "Momma" on day 3 of her trial, the effect can be profound. For us Sytrinol is helpful, but not profound. It is safe and not so expensive and if it does not help, you can always give what is left to a friend/relative with elevated cholesterol.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-77934374170546211462016-04-07T04:42:25.930+02:002016-04-07T04:42:25.930+02:00Thanks Peter. You said that some seem to respond ...Thanks Peter. You said that some seem to respond to sytrinol better than others, i wonder if you know what the profile would be (behaviorally, etc) of the responders -- or non responders? You are always very helpful!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-14659168795402555832016-04-06T22:17:25.164+02:002016-04-06T22:17:25.164+02:00Sytrinol contains two citrus flavonoids tangeretin...Sytrinol contains two citrus flavonoids tangeretin and nobiletin, both have interesting effects: anti-obesity, cholesterol lowering etc. Tangeretin is an agonist of peroxisome proliferator-activated receptors (PPARγ), nobiletin is not an agonist but does effect PPARγ signalling.<br /><br />PPARγ agonist drugs like Pioglitazone (brand name Actos) are prescription drugs used to treat type 2 diabetes. They have been trialled in autism with positive results. But these drugs also have multiple modes of action, which cause side effects. Actos is a big seller in the US, but was withdrawn from some countries because of the side effects.<br /><br />I wanted a safe PPARγ agonist for long term use. Sytrinol looks the best choice.<br /><br />Some NSAIDs like Ibuprofen are also PPARγ agonists, but they have other effects like inhibiting COX-1 and COX-2. The inhibition of COX-1 can cause damage to the mucus lining of the stomach, leading to the known GI side effects of NSAIDs.<br /><br />NSAIDs do seem to benefit many people with autism, and there are multiple possible reasons for this. Inhibiting COX-2 may be the major reason, but being a PPARγ agonist may also play a role. It may even vary from person to person.<br /><br />People who find NSAIDs helpful, but can only tolerate them for the short term, might want to trial Sytrinol to see if it is effective. They might also want to trial Montelukast (Singulair) a leukotriene receptor antagonist, which might also be effective and is usually well tolerated in children.<br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-79837357614049836852016-04-06T19:14:55.159+02:002016-04-06T19:14:55.159+02:00you had mentioned Sytrinol in earlier posts as hav...you had mentioned Sytrinol in earlier posts as having some of the benefits of NSAIDs such as Ibuprofen or Aleve without some of the longer term side effects. Is this benefit you are mentioning in this post for the same issues? Can you elaborate? thank you. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-18955639920843560142016-04-06T10:24:30.935+02:002016-04-06T10:24:30.935+02:00Great news, let us all know the longer term effect...Great news, let us all know the longer term effect.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-9016490387297202352016-04-06T08:22:43.522+02:002016-04-06T08:22:43.522+02:00Day 3 of sytrinol! babbling like crazy. Said MOMMA...Day 3 of sytrinol! babbling like crazy. Said MOMMA. so clearly. numerous times. A little wired at bed time though... went to be two hours later than normal... but he was so proud of all the noises he was making! Thank you Peter!Unknownhttps://www.blogger.com/profile/07290276102260430780noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-17220446279850961422016-04-04T20:11:58.031+02:002016-04-04T20:11:58.031+02:00Zinc helped my daughter's pica when she was ve...Zinc helped my daughter's pica when she was very young. RGhttps://www.blogger.com/profile/07458829468580940361noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-41745035434056655032016-04-04T15:41:06.886+02:002016-04-04T15:41:06.886+02:00There is quite a lot written about using behaviora...There is quite a lot written about using behavioral strategies to reduce pica. You can download some resources here:<br /><br />https://www.autismspeaks.org/science/resources-programs/autism-treatment-network/atn-air-p-pica-guides?utm_source=social-media&utm_medium=text-link&utm_campaign=espeaks<br /><br /><br /><br />There probably is a biological cause/trigger to pica and this most likely varies from person to person.<br /><br />I think the behavioral approach is the best one to follow in this case.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-82473863171174035002016-04-04T15:30:36.250+02:002016-04-04T15:30:36.250+02:00Thanks Peter.My son doesn't take high dose B12...Thanks Peter.My son doesn't take high dose B12. Any other ideas on how to curb the Pica ?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-30949944319787036792016-04-04T09:32:09.283+02:002016-04-04T09:32:09.283+02:00Sytrinol seems to help some people much more than ...Sytrinol seems to help some people much more than others, I would start with 150 mg a day. See if you get a good effect and see if it continues.<br /><br />Pica, putting objects in your mouth, is common in autism. It can also be caused by some supplements, such as high dose vitamin B12. <br /><br />If he has GI issues you might well want to read the guest post on Verapamil. In addition to behavioral effects, it seems to make some people's GI problems disappear. <br /><br />http://epiphanyasd.blogspot.com/2016/03/verapamil-use-in-autism-request-for.html<br /><br />You may find that NAC capsules may cause more problems than mixing the NAC up in food/drink.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-57182410675632536082016-04-04T07:33:00.195+02:002016-04-04T07:33:00.195+02:00Peter... what kind of dosing do you expect for max...Peter... what kind of dosing do you expect for maximum benefit of sytrinol? Also, my son is a chewer... everything in his mouth... his stomach is very sensitive so high dose NAC has been tough... any ideas there for something that might help? TIA! Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-28505287254620620082016-03-29T16:59:59.449+02:002016-03-29T16:59:59.449+02:00Debbie, if was classic autism he would not be arti...Debbie, if was classic autism he would not be articulate and would not be able to give consent to anything. All the autism terminology has been corrupted through over-use and over-diagnosis.<br /><br />The terminology does matter, because if he has normal IQ, Baclofen is likely to help. If has reduced cognitive functioning, then Bumetanide is a good place to start.<br /><br />Oxidative stress affects most people with a autism/asperger's and so NAC is well worth trying.<br /><br />Baclofen and Bumetanide are prescription drugs, NAC is a supplement. If NAC works, you will notice in a couple of days.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-31225171872494069862016-03-29T16:29:58.347+02:002016-03-29T16:29:58.347+02:00Thank you for your prompt reply.
His desruptive n...Thank you for your prompt reply. <br />His desruptive noises are from the time he wakes till he goes to sleep! - not only in school. <br />I think he has classic autism, not aspergers. I have come to the conclusion that what has been missing in his life is ABA therapy. He did have some back when he was first diagnosed at age 2.5 years. He had ABA for about 2 years. We saw wonderful gains. But he 'tricked' us to believe that it would be better for him to have a different variety of interventions as he is so high functioning. i.e. he is very articulate, completely verbal etc BUT he really is autistic to the core. We really have tried so many things and have not made much of a dent. <br />I am understandabley very frustrated. <br />We have tried homeopathy, supplements, and were even going to be participating in the drug study you mention above on Piogliatizone, but he did not give his consent and they did not allow it. He was 9 at the time!!<br /><br />What do you suggest if we were to try one or two of your recommendations? and how long will it take to see any results? <br /><br />Anonymoushttps://www.blogger.com/profile/15995598250269300434noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-70954240809346997292016-03-29T15:27:53.393+02:002016-03-29T15:27:53.393+02:00This could be a kind of verbal stereotypy, or it c...This could be a kind of verbal stereotypy, or it could be a behavioral response. Does it only happen in school?<br /><br />If it is stereotypy it well worth trying NAC 600mg three or four times a day. You will know in a day or two if it works.<br /><br />It could be his way of dealing with anxiety, which is a big issue in Asperger's but not really in most classic autism. Anxiety in Asperger's seems to respond extremely well (70+% response rate) to Baclofen. It seems that 5-15 mg three times a day is what works. Baclofen seems to resolve many issues in Asperger's, so well worth trialing. Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-7154393845259382522016-03-29T02:09:01.824+02:002016-03-29T02:09:01.824+02:00my high functioning son (11), makes very annoying ...my high functioning son (11), makes very annoying "crazy" noises. Very disruptive to his peer/teachers. they are a combination of the movies he has watched, books read, computer games. I have read through your blog but not come across this issue. Anonymoushttps://www.blogger.com/profile/15995598250269300434noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-17438875538529860832016-03-27T07:12:46.757+02:002016-03-27T07:12:46.757+02:00From my understanding, the inducing of magnesium d...From my understanding, the inducing of magnesium deprivation is done to induce seizures which are then studied and this is a very common albeit probably standard method of doing so. Magnesium helps modulate NMDA receptor activity and depriving the receptors of magnesium causes them to be oversensitive to activity and if you do that throughout the brain or a whole brain region you get a cascade of uninhibited activity which can lead to seizures.Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-51461530687099592962016-03-26T03:32:05.241+01:002016-03-26T03:32:05.241+01:00I know - magnesium does not solve everything - but...I know - magnesium does not solve everything - but just wanted to point out a couple connections. Also, I think it is interesting that you point out the link between autism and Alzheimer's, because just for fun in my spare time, I have been trying to find links between the two, (I realize people have done this before) and the TAU group of Israel has stated that there is a genetic link between the two, both having issues/mutations in the ADNP gene, which affects neuroprotection. Reading your post, it was coincidental that you posted about Diabetes type 3 and autism because I was just looking at that a few days ago - insulin thought not to be produced only in the pancreas but also in the brain. Up until a few days ago I had never heard of that concept before. I was wondering at the time how calcification or aluminum toxicity in the brain (both mg issues) and a lack of ionic magnesium specifically (the health benefits possibly being totally different for ionic magnesium) might contribute to Diabetes 3, and yes I agree that an individual with autism might be suffering from some degree of Diabetes 3 for sure. Magnesium is supposed to be crucial for both production and use of insulin, so it is no coincidence that black people have low magnesium, low insulin, and high rates of regressive type autism. Just out of interest, I had never heard of PPARgamma but I did find one study where PPARgamma was being tested - I found it interesting that, in order to create neurological vulnerability that would be responsive to PPARgamma, the researchers made the experimental mice magnesium deficient. Tootiehttps://www.blogger.com/profile/03249516637029480332noreply@blogger.com