tag:blogger.com,1999:blog-655962722302095847.post1602156109266974319..comments2024-03-28T22:33:35.806+01:00Comments on Epiphany: Nystatin in autism - a potent Potassium Channel Kv1.3 blocker (anti-inflammatory) or an antifungal/candida treatment?Peter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger25125tag:blogger.com,1999:blog-655962722302095847.post-79868301040639945192023-04-23T23:34:08.656+02:002023-04-23T23:34:08.656+02:00I want to say that we used rifaximin courses accor...I want to say that we used rifaximin courses according to the Nemechek protocol for 1.5 years monthly for 10 days. My daughter is 12 years old, she is non-verbal and only rifaximin helped us to keep the behavior, less stimming and vocalizations.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-14361090413626764572023-04-23T09:57:24.196+02:002023-04-23T09:57:24.196+02:00Gut dysbiosis can have all kinds of symptoms all o...Gut dysbiosis can have all kinds of symptoms all over the body. I suspect the cardiologist's daughter would respond well to Rifaximin.<br /><br />FMT clearly benefits some people, but it has no effect on others.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-38990730881475470782023-04-23T05:46:33.057+02:002023-04-23T05:46:33.057+02:00Peter,
I have found a Cardiologist in Hyderabad w...Peter,<br /><br />I have found a Cardiologist in Hyderabad who is actually doing FMT for autism. It seems to have helped his own daughter, so he is running a small clinic for others too, almost as charity service. We have decided to give it a try - at least 3 to 5 infusions and see what happens.<br /><br />Interesting thing is that the doctor mentions that whenever he sees any flares in his daughter, he does a few sessions of FMT for her daughter, which he says help her. He mentioned a particular syndrome (I could not gather the name) where the eyes become swollen and yellow. He said that the standard therapy for it is just steroids, but FMT resolves it in his daughter's case. I wonder what you think about this - is it crazy to think that you can use the gut to say, treat an ear infection?<br /><br />Website for those interested: https://gsrt.co.in/resplice-reconnect-center/<br /><br />Anveshdeathmetal124https://www.blogger.com/profile/01648315648704509821noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-81689892981118107472022-04-19T07:16:57.403+02:002022-04-19T07:16:57.403+02:00Anvesh, you likely have gut dysbiosis as well as c...Anvesh, you likely have gut dysbiosis as well as candida and this has been linked to ADHD in some people.<br /><br />Once you treat the candida, try and improve diet. This may well solve the problem.<br /><br />If you cannot improve diet and hence develop a balanced gut microbiome then you might think about FMT. FMT should not be needed, use behavioral strategies to get him to eat better. Not easy, but it is possible.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-59945396245286960802022-04-18T19:05:59.692+02:002022-04-18T19:05:59.692+02:00Peter,
We got the stool test report from the CSAP...Peter,<br /><br />We got the stool test report from the CSAP lab for my (almost) 5 yr old son Vik who is mild/moderate ASD. It was ordered by a MAPs doctor. The stool culture noted several different types of candida and our doctor remarked that this is the most yeast she has seen for any of her patients. She prescribed Nystatin, but I could not procure here in India, where I am now, so we started with Diflucan.<br /><br />Screenshot of the report here: https://imgur.com/a/0C1HhdV<br /><br />My son does not really have any major GI issues.. he has rarely had any diarrhea or constipation. He used to be a very good eater before he turned 4 and he now eats about half (volume and variety) of what he used to eat a year ago. Our pediatrician dismisses that as just a behavioral thing accompanying autism. <br /><br />He also used to be a quiet and fairly self-contented guy a year ago, but he has started becoming more "hyper" (jumping from sofas, clenching teeth often, screaming and running back and forth, squeezing sister's feet hard and forcefully tickling and even, pushing people). This has gotten worse over last year and you can see that he is almost compelled to do these things.<br /><br /><br />My question to you is:<br /><br />1) Do you think the candida alone can cause these behaviors?<br />2) I have found that a couple of hospitals in Bangalore have experience in FMT for C.Difficle. Would it be too early to give FMT a try?<br /><br />Regards,<br />AnveshAnveshnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-84623350867475131052021-03-27T17:50:33.965+01:002021-03-27T17:50:33.965+01:00Hi Peter, we had opposite reaction to Nystatin and...Hi Peter, we had opposite reaction to Nystatin and spike in seizures like episodes . At some point we had borderline autoimmune marker (Neuronal (V-G) K+ channel Ab) but it was tested in rather stable period. We have quite a few underlying genetic issues among which are two calcium channelopaties. We have as well immune susceptibility to candida and fungal infections as well . Trying to figure out why was negative response to Nystatin in our case. Martynahttps://www.blogger.com/profile/13221791262907895018noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-33833332150670728682019-01-30T10:08:42.795+01:002019-01-30T10:08:42.795+01:00Nystatin when taken by mouth should not enter the ...Nystatin when taken by mouth should not enter the bloodstream in healthy people; it should not pass through the gut and therefore should not be able to block ion channels outside the gut.<br /><br />Does nystatin enter the blood stream in some people with autism? That could easily be measured by a lab, but nobody has done this.<br /><br />So there is no Kv1.3 blocking dose for oral nystatin.<br /><br /> Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-79497643614271412722019-01-30T07:41:37.985+01:002019-01-30T07:41:37.985+01:00Hi all, for potassium blocking effect is the nysta...Hi all, for potassium blocking effect is the nystatin dosing schedule different then for yeast? Aidreynoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-90930209504786690312018-09-27T11:26:36.274+02:002018-09-27T11:26:36.274+02:00Peter it is just general yeast... and candida on m...Peter it is just general yeast... and candida on my tongue, nystatin seems to target both.<br />On top of that nystatin seems to have a mood effect on some and actually hits serotonin receptors in the brain.<br />Ketoconazole sounds like chemical castration something im not looking forward to.<br /><br />https://www.ncbi.nlm.nih.gov/pubmed/15219865<br /><br />I'll discuss it with my regular doctor, the ketoconazole script was provided by the dermatologist.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-35858816981171593522018-09-27T10:56:19.237+02:002018-09-27T10:56:19.237+02:00Aspie1983, Nystatin also can have side effects, th...Aspie1983, Nystatin also can have side effects, though I have never used it. It is best to discuss your concerns with your doctor.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-31416705482295406592018-09-27T10:22:26.451+02:002018-09-27T10:22:26.451+02:00I have yeast on my skin (confirmed by a dermatolog...I have yeast on my skin (confirmed by a dermatologist today) and have candida on my tongue.<br /><br />Peter, they gave me a script for topical ketoconazole, but after reading the side effects I do not want to use that. Do you think that topical/oral nystatin could be effective?<br /><br />I have absolutely no experience at all with antifungals, so going to need some help people.<br /><br />As a side note, Im still using psilocybin microdoses once every 3/4 days and it has a dramatic effect on getting rid of my depression in a very different type of way than SSRI's did.Aspie1983https://www.blogger.com/profile/14186355234793738967noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-45095925430817280822017-10-21T22:06:46.611+02:002017-10-21T22:06:46.611+02:00Hi,
I found this article from 2017 that describes...Hi,<br /><br />I found this article from 2017 that describes how the Kv1.3 channel (relevant for chronic auto-immunity issues and blocked by Verapamil) and the KCa3.1 channel (relevant in acute immunity reactions) work together in T-cells. It reveals that the KCa3.1 channel can compensate for the other channel and also that it is the number of exposures to antigen that dictates whether Kv1.3 or KCa3.1 is the prevalent channel.<br /><br />"we demonstrate that Kv1.3 is the predominant functionally active channel in T cells subjected to repeated specific antigen exposure and that KCa3.1 compensates for loss of functional Kv1.3 as in the presence of Kv1.3 inhibitors."<br />"The mechanisms responsible for conversion from KCa3.1 to Kv1.3 dependency remain to be elucidated"<br /><br />Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions<br />https://www.nature.com/articles/ncomms14644<br /><br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-72587861573442249262017-08-29T22:01:42.561+02:002017-08-29T22:01:42.561+02:00Know any in the US??Know any in the US??Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-82605020216566810432017-08-29T09:40:42.777+02:002017-08-29T09:40:42.777+02:00Diflucan/Fluconazole therapy has been associated w...Diflucan/Fluconazole therapy has been associated with QT interval prolongation.<br /><br />The QT interval is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle.<br /><br />Inherited long QT syndrome is caused by mutations of at least 5 ion channel genes. Mutations of the cardiac sodium ion channel gene and 3 potassium channel genes have been identified to this time.<br /><br />So I think it is fair to think that Diflucan may be affecting one or more ion channels that are dysfunctional in your child. This is not surprising since channelopathies are part of autism. <br /><br />Calcium channels may also be involved, since Diflucan’s potency as an antifungal is actually increased when combined with a calcium channel blocker.<br /><br />N-type calcium channel autoimmunity to likely highly relevant to your son’s unusual type of autism.<br /><br />The detection of α3-AChR autoantibody further suggests neurological autoimmunity (autonomic neuropathy).<br /><br />I think you need to see a specialist at a leading children’s hospital to check the significance of the autoimmunity. There may be an underlying cause.<br />Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-19852641667328614712017-08-29T01:46:48.380+02:002017-08-29T01:46:48.380+02:00My son responds within hours to Diflucan. I can...My son responds within hours to Diflucan. I can't believe if it was truly yeast, that he would respond so quickly. The main major improvement is sleep. Solid 11-12 hours of sleep. Normally, he wakes in the middle of the night and goes to someone else's bed. Sometimes can be up for several hours. He is positive for N Type calcium channel binding antibody and Neuronal AChR, Ganglionic (Alpha-3). I have read and read about the calcium antibodies, but I can't make much sense of it and how it may be related to my son's autism. He is taking Bumetanide now. Interestingly, he has had positive serum for the calcium antibody for over a year, he has been taking Bumetanide for 1 month and this last panel came back with calcium antibody WNL. Still positive for the AChR. Any thoughts on what the calcium antibodies may have to do with autism and what the Diflucan may really be doing? Is there an off label effect happening? Thanks,Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-90755966508174629572017-03-07T22:45:05.485+01:002017-03-07T22:45:05.485+01:00Not so fast Peter! Acyclovir is known to inhibit I...Not so fast Peter! Acyclovir is known to inhibit IDO, and it is easy to imagine valacyclovir/valtrex having the same effect.<br /><br />And as IDO is so very closely involved in (messing up) tryptophan metabolism - read dysregulate serotonin/melatonin/niacin/quinolinic acid levels ... it is likely that tweaking IDO activity and lowering its levels would have positive effects in some.<br /><br />To illustrate:<br /><br />https://neuroendoimmune.wordpress.com/2014/03/04/is-oxidative-stress-stealing-your-serotonin/<br /><br />https://www.ncbi.nlm.nih.gov/pubmed/18665439<br /><br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925358/<br /><br />Last but not least<br />http://onlinelibrary.wiley.com/doi/10.1211/0022357056442/abstractNatnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-58834744692278723312017-03-07T10:13:31.251+01:002017-03-07T10:13:31.251+01:00Valtrex, which is used by DAN type doctors, is mea...Valtrex, which is used by DAN type doctors, is meant to treat the herpes virus. Apparently in some people it increased the level of glutathione, which means it has antioxidant properties. Viral infections would not be positive for anyone's health, but treating a non-existing virus may be unwise. As usual you have to draw the line yourself between fact and fiction. Some people with autism will have picked up a herpes virus and Valtrex should indeed help them.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-22763425063233020762017-03-06T23:07:35.585+01:002017-03-06T23:07:35.585+01:00Peter,
Like nystatin antivirals are also widely us...Peter,<br />Like nystatin antivirals are also widely used for ASD and many parents vouch for their effectiveness. Have you done any research? Do antivirals act on anything else apart from virus?salempeacockhttps://www.blogger.com/profile/15527897267296882556noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-54161761708929105472016-12-04T07:19:19.590+01:002016-12-04T07:19:19.590+01:00Fluconazole is known to lower the level of potassi...Fluconazole is known to lower the level of potassium in your blood, which would likely affect potassium channels. <br /><br />With many DAN interventions they have found something that affects a minority and then assume it affects everyone. I think some people likely do have odd behavioural reactions to a candida infection, like after using some steroid oral inhalers. This does not mean everyone has a problem and then some people's lives get taken over by thinking candida is driving their type of autism.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-54669907541576597742016-12-04T05:27:14.440+01:002016-12-04T05:27:14.440+01:00Hi Peter, another paper this fall linked Candida t...Hi Peter, another paper this fall linked Candida tropicana species with Crohn's disease. https://www.sciencedaily.com/releases/2016/09/160920151435.htm. I am wondering if you have found any papers on if Fluconazole (Diflucan) also affects potassium channels - it is a more systemic anti-candida agent and also it is used in autism treatment by DAN doctors - I would imagine it would have a better effect than Nystatin due to this systemic effect, however have not tied it yet. I also could not find how it affects potassium channels but maybe I am not searching correctly. <br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-22328952801300895482016-05-15T15:49:19.715+02:002016-05-15T15:49:19.715+02:00Thank you Peter for your adviceThank you Peter for your adviceAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-5502780827337489882016-05-14T12:33:10.140+02:002016-05-14T12:33:10.140+02:00I would suggest you read about Agnieszka's stu...I would suggest you read about Agnieszka's study on verapamil, the link is at the top of the blog on the right side opposite the date. I think your child very well may be a responder and I am sure if you contact her via the email in her guest post she will answer your questions and hopefully enroll in her case series.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-66898505307485964262016-05-14T09:33:55.996+02:002016-05-14T09:33:55.996+02:00My 6 year old daughter with severe autism non verb...My 6 year old daughter with severe autism non verbal-has associated auto-immune/inflammatory conditions this include abnormal GI conditions. Nystatin one of best interventions first day she was given spoke a four word sentence not been repeated unfortunately words very few come and go never retained.<br />Been to well recognised gastrologist in Europe, who insists she has no yeast ,but chronic Hpylori low white blood count.gave ketotofin and later treated hpylori miracle drug ketotofin pain in tummy stopped aggresion sib stopped unfortunately reaction to ketotofin xyzal now given not as effective always bad reaction to calcium supplements,reacts to zinc,and probably magnesium and potassium.Nalcrom great,eye drop,loratadine all helping ,More gains NAC,Australian sprouts thanks to Agnieszka and yourself .what do you think would be helpful.I am terming her classic.Little success with natural supplements great success with pharmaceuticals<br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-6385534964220833912015-08-07T19:10:20.817+02:002015-08-07T19:10:20.817+02:00Yes, I am suggesting that Nystatin may be helping ...Yes, I am suggesting that Nystatin may be helping some people with autism for reasons unconnected with Candida.<br /><br />The reason why steroid inhalers are safe is that the steroid does not enter the bloodstream. <br /><br />The drug producer does say that:-<br /><br />•Localized infections with Candida albicans have occurred in the mouth and pharynx in some patients receiving QVAR. Advise rinsing of mouth after use. If oropharyngeal candidiasis develops, QVAR may need to be temporarily interrupted under close medical supervision <br /><br />They refer to the candida as being localized.<br /><br />Maybe try a different steroid inhaler? We use Flixotide.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-55520049411388231852015-08-07T18:38:05.125+02:002015-08-07T18:38:05.125+02:00Hi Peter,
I wanted to ask about Nyastatin for a wh...Hi Peter,<br />I wanted to ask about Nyastatin for a while. I just found this post on your blog, the reason is my son got diagnosed after we started him on QVAR and flovent (steroid inhalers for asthma) and his stimming went through the roof, the doc told us candida is a side effect and I should wash his mouth, always wondering if the candida increased increaed in his gut.<br />In the post above, it seems like Verpamil would affect behavior in a similar way as Nyastatin - true?<br />Thanks<br />BKAnonymousnoreply@blogger.com