tag:blogger.com,1999:blog-655962722302095847.post1068263718714345301..comments2024-03-28T22:33:35.806+01:00Comments on Epiphany: P-Cresol, like Propionic acid – a cause of Transitory Autism for some and a further burden for others Peter Lloyd-Thomashttp://www.blogger.com/profile/10173383229834614994noreply@blogger.comBlogger31125tag:blogger.com,1999:blog-655962722302095847.post-33852844504483827652024-01-13T18:47:23.449+01:002024-01-13T18:47:23.449+01:00I guess there is another mtor inhibitor you can ge...I guess there is another mtor inhibitor you can get without a prescription. It is part of the rhubarb family. It also effects proprionic acid. <br /><br />https://pubmed.ncbi.nlm.nih.gov/35687217/Unknownhttps://www.blogger.com/profile/04570315027088928366noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-68420365532116621142023-07-25T06:36:23.693+02:002023-07-25T06:36:23.693+02:00Furthermore, Emodin helps with the BBB and decreas...Furthermore, Emodin helps with the BBB and decreases edema in the brain after a stroke.<br /><br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048947/Unknownhttps://www.blogger.com/profile/04570315027088928366noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-82382456801338981352023-07-24T10:35:07.130+02:002023-07-24T10:35:07.130+02:00P-cresol and brain inflammation. Probably explains...P-cresol and brain inflammation. Probably explains why the vancomycin study worked but failed after stopping vancomycin. Same garden same weeds.<br /><br />https://www.mdpi.com/1422-0067/23/19/11013<br /><br />-Stephen Unknownhttps://www.blogger.com/profile/04570315027088928366noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-63713374404656536822023-06-30T14:36:01.685+02:002023-06-30T14:36:01.685+02:00Even more interesting is how Emodin decreases ROS....Even more interesting is how Emodin decreases ROS.<br /><br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215870/<br />Unknownhttps://www.blogger.com/profile/04570315027088928366noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-77655712365195265872023-06-29T21:27:13.190+02:002023-06-29T21:27:13.190+02:00Interesting, StephenInteresting, StephenPeter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-9381347568083144652023-06-29T16:22:22.422+02:002023-06-29T16:22:22.422+02:00Emodin might decrease the levels of p-cresol by mo...Emodin might decrease the levels of p-cresol by modulating the gut bacteria that produce it. <br /><br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951226/<br /><br />Also, it appears it is urinated it out. So bumetanide could probably help with this. <br /><br />https://pubmed.ncbi.nlm.nih.gov/25010144/<br /><br />-StephenStephennoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-57872364131188070472022-11-26T05:48:27.564+01:002022-11-26T05:48:27.564+01:00NiceNiceSafia Jilanihttps://www.blogger.com/profile/17165257606577817427noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-78765896545722068952022-05-24T09:53:52.326+02:002022-05-24T09:53:52.326+02:00What this is suggesting is that gut dysbiosis may ...What this is suggesting is that gut dysbiosis may aggravate autism by producing harmful substances, not limited to p-cresol and propionic acid. There is a two way communication gut to brain and brain to gut.<br /><br />With regard to gut to brain communication you can optimize the situation by eating a varied healthy diet rich in fruit, vegetables, berries, fish, fiber etc. You need to avoid any foods you are allergic to or have intolerance. Some people may need medication like cromolyn sodium. People with very poor diet may need interventions like FMT, to get the right balance of bacteria growing inside them and have normal GI function.<br /><br />There is also brain to gut communication and people with activated microglia in the brain might be sending pro-inflammatory signals to the gut leading to IBS/IBD.<br /><br />Most peoples autism has multiple dimensions, whereas research models have just one and are a simplification.<br /><br />You daughter has some GI issues and she responds to L-carnitine. The two may or may not be connected. The more you can improve GI function the better off she will be, but most likely this will not be sufficient. You will have to look at brain specific therapies.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-61573458534413765862022-05-24T02:48:14.857+02:002022-05-24T02:48:14.857+02:00This is fascinating, thank you for sharing. I can&...This is fascinating, thank you for sharing. I can't say how thankful I am that this blog exists. It's been so helpful for me.<br /><br />My daughter is 4 and is yet to receive an autism diagnosis, but she I would say partially fits the description of mild autism. Our main concern is speech delay and echolalia which also makes it difficult (alongside her steel will) to encourage her to do anything other than what she wants to do (i.e. use utensils, dress/undress herself, signal when she needs to use the restroom, etc.).<br /><br />I had not considered autism to be a possibility until recently when her deficits became more apparent after a "regression" which was less of a regression and more of a plateau. L-carnitine is helping a lot in the short time we've been using it (indicating mitochondrial involvement).<br /><br />Reading this post, I'm realizing that her gut issues could be more involved than I thought. She has dealt with chronic constipation since she was very young, which we eventually identified was related to a cow's milk sensitivity. However, even though her exposure to dairy is minimal, she still deals with mild constipation and I wouldn't consider her regular. I wonder if it could be contributing to her symptoms, especially given it's more common among females with autism.<br /><br />I have found that Lactobacillus rhamnosus GG helps a lot with her constipation but doesn't make her completely regular. I've purchased some inulin to see how she responds.<br /><br />To be clear: this is suggesting gut dysbiosis could be increasing P-cresol / propionic acid could be a contributor to transitory autism -- in that, if the issue is addressed, the symptoms could be ameliorated? Or that a normal decrease in P-cresol over time could explain transitory autism? Also, could it be possible that something like L-carnitine could be working further downstream to counteract effects of P-cresol / propionic acid on the mitochondria?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-91093855214426095772021-02-05T15:31:27.560+01:002021-02-05T15:31:27.560+01:00Julie, the posts below look at dietary autism and ...Julie, the posts below look at dietary autism and SIBO.<br /><br />https://epiphanyasd.blogspot.com/2019/12/dietary-autism-therapy-it-clearly-works.html<br /><br />https://epiphanyasd.blogspot.com/2020/05/psychobiotics-ps128-for-autism.html<br /><br />The wonder therapy for some people is Rifaximin. It is a prescription drug normally given to adults, but it is the standard therapy for SIBO. You could try asking your GP.<br /><br />If you are in the UK, you may be able to obtain it from a legitimate online pharmacy, if you complain about traveller’s diarrhea in an adult. Just google “buy rifamixin uk” and you will see several options.<br /><br />You just take one course of Rifamixin and see if behaviours improve. You do not need to take it all the time.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-42639921224702882812021-02-05T12:34:17.292+01:002021-02-05T12:34:17.292+01:00Dear Peter, I can't thank you enough for your ...Dear Peter, I can't thank you enough for your generosity in taking the time to share your knowledge. My son is 11 and is ASD. Just as a background, our approach all these years has been mainly a balanced, very nutritious diet (Weston A Price) limiting gluten/refined carbs, and complementary therapies such as homeopathy and osteopathy. They helped very much in our case and he has been mainstreamed for many years. He still has challenges, particularly socially. I have been researching gut related issues for years (SIBO etc..) as although he has regular BMs (well formed), he must have gut fermentation issues as eating a high glycemic meal causes behaviour changes (the usual silliness commonly associated by lay people with yeast, giggling, etc.). He develops breath that smells of alcohol and does behave like someone who is tipsy. We tried inulin in the past (while trying the Nemechek protocol) for 3 months and ended up stopping because he became slightly rude and antagonistic. I have read many of your articles/searched the site, but if you could please kindly point me to another of your posts about this or if you know anything that could help us help our son and steer in that direction, it would be amazing. GP was absolutely of no help of course. Thank you so much. Juliehttps://www.blogger.com/profile/03828932022277070637noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-13104394475446843072020-07-21T20:00:50.359+02:002020-07-21T20:00:50.359+02:00Valentina,
The balance of carbs and fats in the di...Valentina,<br />The balance of carbs and fats in the diet can affect constipation. (many/most?) carbs absorb water in the gut so eating more carbs can cause constipation until the gut adapts and produces more water. (Maybe takes a few days / a week or two) Obviously dehydration can cause problems here as well. Conversely, eating more fat and fewer carbs can produce diarrhea because of the excess water produced by the gut (again, until it adapts to the changed diet).<br />Aspie2Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-32192883192445419012020-07-08T16:06:32.646+02:002020-07-08T16:06:32.646+02:00considering that you don’t write all that much abo...considering that you don’t write all that much about stem cells and that I have spent a long time researching them, here are my conclusions on them for all readers here: 1. there are several types of stem cells. they all have different ways they act in the body. your best pick is to throw a coin since nobody in the world could tell you what will work for your child. from many hundreds if not thousands of experiences it seems that alternating cord blood with cord tissue is the best. both in the us and in europe there is a lot of availability of cord tissue therapy and very little of cord blood. however, i believe everybody should try it, especially considering that it doesn’t cost the world. 2. if you have gains, they will appear anytime from day one until 6-8 months after. they can really come on quite suddenly after several months when you think nothing happened. there is no telling what the gains would be 3. all stem cell therapies lead to immune suppression which leads to pans like issues and herpes virus reactivation. best is to do some antiviral antibacterial antifungal prophylaxis the first 2 weeks after receiving cells. 4. Duke, which has done so much with stem cells so far in autism, has derived some strange conclusions which are not at all what the community of parents who have used them have noticed. I have naturally read a lot of papers on stem cells and also, due to events surrounding my daughters cord blood, I have talked personally to most of the top researchers in stem cells in the world including dr Kurtzberg. If you have around 2-3 thousands euro/dollars, I would give a commercially available stem cell product like Corecyte, Predictive in the US or stem cell therapy in private clinics in Poland a try.tpeshttps://www.blogger.com/profile/01788229993969295249noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-38396774747065112192020-07-07T22:06:06.872+02:002020-07-07T22:06:06.872+02:00Hello Peter, I hope you and your family are doing ...Hello Peter, I hope you and your family are doing well. My son's GI problem is mostly diarrhea, and other days of constipation but he has been better with verapamil though I believe his gut problems have not been resolved, I committed several mistakes with his food trying to make him healthy meals, when he was 1.8 years I gave him a barley tortillas and he couldn't sleep for days because of the stomach ache, he had many nights like that before he started taking verapamil, he also received antibiotics and paracetamol from a young age. I'd give him yakult almost every day, but I never saw a difference. I came across a study about agave inulin and they found out that only agave inulin makes a certain bacteria that helps diminish inflammation to be more scarce so chicory inulin or other type of might be better. I found also an article about a study with Rifaximin, and it reminded me about your post on Psychobiotics, the effect is very similar to the probiotic PS-128 on social stress, I don't know if the study comes from a reliable source, but I've been thinking about it, and I wanted to ask you what do you think, is there a possibility it could be used low dose long term? or maybe intermittently? I haven't even tried it but it seems very interesting.<br /><br />This is the study on Rifaximin: https://link.springer.com/article/10.1007/s13311-018-0627-2Lisa https://www.blogger.com/profile/00797983091361495962noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-90757563343632611172020-07-07T20:41:19.322+02:002020-07-07T20:41:19.322+02:00Fasting makes your body produce stem cells and sen...Fasting makes your body produce stem cells and send them places to repair stuff. which means (and they really do) that stem cells help in autism. Peter, Enrique B from the Autism research coalition is taking his kids for Embrel tomorrow, will let you know how that went. tpeshttps://www.blogger.com/profile/01788229993969295249noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-32719698216194057902020-07-04T09:45:03.721+02:002020-07-04T09:45:03.721+02:00Ling, fasting has come up several times before in ...Ling, fasting has come up several times before in this blog. Your body have evolved to expect periods of plenty and periods of famine. Fasting does trigger beneficial processes and, assuming you are not anorexic to start with, it is clearly a good thing.<br /><br />Modern diet, for many people, involves constant snacking.<br /><br />I think fasting would be hard to apply as an autism therapy for children, but it is important to avoid such children becoming obese, as they often are. Living in the US increases your risk of obesity - food is cheap and portions are huge.Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-61896523032056031812020-07-04T05:32:48.336+02:002020-07-04T05:32:48.336+02:00Thanks Peter will check on the P-Cresol lab test.I...Thanks Peter will check on the P-Cresol lab test.If it an issue, he will feel better, but like you have suggested before, the critical time was to recognize this earlier. He def. had gut issues as a youngster and obviously he cognitively would have been better if this were caught earlier. It is about marginal improvement at this stage, which is better than no improvement, not return to full potential. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-7633695350297899112020-07-03T23:13:49.210+02:002020-07-03T23:13:49.210+02:00Peter, what about Ramadan as autism treatment? I&#...Peter, what about Ramadan as autism treatment? I'm partly kidding here, but it looks like there are good health reasons to this custom:<br />https://www.sciencedirect.com/science/article/pii/S1874391920300130<br /><br />/LingAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-30048951615492691222020-07-03T11:33:11.999+02:002020-07-03T11:33:11.999+02:00Even though much mass media still says there is no...Even though much mass media still says there is no evidence to show any benefit from Hydroxychloroquine, here is yet another research paper showing a substantial reduction in mortality.<br /><br /><br />Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis<br /><br />https://www.sciencedirect.com/science/article/pii/S1477893920302817<br /><br />Background<br /><br />In our institute in Marseille, France, we initiated early and massive screening for coronavirus disease 2019 (COVID-19). Hospitalization and early treatment with hydroxychloroquine and azithromycin (HCQ-AZ) was proposed for the positive cases.<br /><br />Methods<br /><br />We retrospectively report the clinical management of 3,737 screened patients, including 3,119 (83.5%) treated with HCQ-AZ (200 mg of oral HCQ, three times daily for ten days and 500 mg of oral AZ on day 1 followed by 250 mg daily for the next four days, respectively) for at least three days and 618 (16.5%) patients treated with other regimen (“others”). Outcomes were death, transfer to the intensive care unit (ICU), ≥10 days of hospitalization and viral shedding.<br /><br />Results<br /><br />The patients’ mean age was 45 (sd 17) years, 45% were male, and the case fatality rate was 0.9%. We performed 2,065 low-dose computed tomography (CT) scans highlighting lung lesions in 592 of the 991 (59.7%) patients with minimal clinical symptoms (NEWS score = 0). A discrepancy between spontaneous dyspnoea, hypoxemia and lung lesions was observed. Clinical factors (age, comorbidities, NEWS-2 score), biological factors (lymphocytopenia; eosinopenia; decrease in blood zinc; and increase in D-dimers, lactate dehydrogenase, creatinine phosphokinase, and C-reactive protein) and moderate and severe lesions detected in low-dose CT scans were associated with poor clinical outcome. Treatment with HCQ-AZ was associated with a decreased risk of transfer to ICU or death (Hazard ratio (HR) 0.18 0.11–0.27), decreased risk of hospitalization ≥10 days (odds ratios 95% CI 0.38 0.27–0.54) and shorter duration of viral shedding (time to negative PCR: HR 1.29 1.17–1.42). QTc prolongation (>60 ms) was observed in 25 patients (0.67%) leading to the cessation of treatment in 12 cases including 3 cases with QTc> 500 ms. No cases of torsade de pointe or sudden death were observed.<br /><br />Conclusion<br /><br />Although this is a retrospective analysis, results suggest that early diagnosis, early isolation and early treatment of COVID-19 patients, with at least 3 days of HCQ-AZ lead to a significantly better clinical outcome and a faster viral load reduction than other treatments.<br /><br /> Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-63488908236419698792020-07-03T10:14:11.826+02:002020-07-03T10:14:11.826+02:00Mary, measuring P-Cresol in urine is a standard la...Mary, measuring P-Cresol in urine is a standard lab test. If you are worried about it, you can do the test. If P-Cresol was elevated in a 21 year old, you would expect an improvement after correcting it.<br /><br />Using inulin would be simpler/safer than a microbiome transplant. The research showed that P-Cresol disturbed the microbiome and transplanting a "normal" microbiome solved the problem.<br /><br />In humans you would need to be sure of what you are are transplanting and I expect this will mean this remains a rare procedure. I think you would want the microbiome of a healthy neurotypical person who eats a varied Mediterranean-type diet; not someone who eats KFC, Mc Donalds and processed pizza. Peter Lloyd-Thomashttps://www.blogger.com/profile/10173383229834614994noreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-67682921661608000462020-07-03T09:56:10.070+02:002020-07-03T09:56:10.070+02:00Interesting. That is almost exactly the regimen I ...Interesting. That is almost exactly the regimen I have for my mother as a preventative measure (keep the immune system responsive but excess runaway inflammation at bay).Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-12091560927051992782020-07-03T09:54:00.080+02:002020-07-03T09:54:00.080+02:00In other words, in the USA we employed the reverse...In other words, in the USA we employed the reverse rational policy of trying to prevent rapidly building herd immunity among the very low-risk groups (children and young adults), while exposing the elderly in nursing homes to infected COVID-19 patients direct from the hospital, as well as infecting them with zero testing of staff who are often on prison work-release programs in some states and giving them zero PPE gear nor requiring it. Plus, while people can see what is going on with respect to PPE use in your local supermarket, due to social distancing rules, relatives could not check on the staff in nursing homes to see if they are even using good hygiene guidelines or else if those in the nursing home are being abused.<br /><br />As a result, we destroyed the economy, have no herd immunity, unnecessarily killed thousands of elderly people who needed protection while some governors were obsessed about policing children playing in their backyard, and now we leave the surviving elderly playing Russian Roulette with COVID-19 in public society indefinitely because herd immunity was never achieved.<br /><br />Fortunately, the one silver lining of the mass nationwide protests and riots is it destroyed social distancing so young people can finally get infected and build up herd immunity to protect those at high-risk. There is now a "second-wave" hysteria building by dishonestly presenting statistics that are irrelevant to public health policy such as focusing on "cases" rather than "deaths", but I am not so sure police will enforce that too much now that they have been unreasonably asked to be assaulted by rioters without fear of arrest while at the same time arresting otherwise law-abiding people who don't obey the edicts of their mayors and governors.Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-30068875352813143962020-07-03T09:53:41.932+02:002020-07-03T09:53:41.932+02:00Well a very recent COVID-19 study here in the USA ...Well a very recent COVID-19 study here in the USA looking at a control group, Hydroxychloroquine only group, Azithromycin only group, and a Azithromycin plus Hydroxychloroquine group in mortality of hospitalized patients showed that the Hydroxychloroquine only group fared best with the Hydroxychloroquine plus Azithromycin group being second best and the Azithromycin only group being third best and the control group being last in terms of improved mortality. Of course if you pay attention to some news outlets, they try and point out severe heart damage from Hydroxychloroquine which in this particular study found zero heart damage in any of the patients.<br /><br />But considering there is a 0.04% mortality rate for those under age 70, you don't have much to worry about unless you are in a high-risk group. Of course cases in the United States are not surprisingly increasing a bunch in the last month due to relaxation of lockdown rules as well as 5% of the population admitting to being part of protests/riots in the last month, but deaths per day keep steadily going down in spite of the dramatic rise in cases. Why is this the case? Well simply put it is my opinion that early in the pandemic, many states actually had deadly policies that dramatically increased the death rate by forcing people to stay indoors with their loved ones, thereby increasing viral load, while at the same time egregiously putting elderly COVID-19 patients in nursing homes under the premise of getting them out of the hospital so that they would not infect others there. Whatever the intent was, it amazingly caused a huge spike in deaths in this group where you had greater than 50% of COVID-19 deaths coming from nursing homes (nationally I think the rate is 40% even though the nursing home deaths vary dramatically from state to state depending on the policies). The survivors of COVID-19 nursing home outbreaks now have immunity so many in the high-risk group either died or are largely immune while the young have been stuck at home playing video games and do not have immunity.<br /><br />That being said, since all of the highest risk people have been infected already due to very poor public health policy which employed with worst possible strategy, all of the younger low-risk people getting infected will not die of COVID-19 in sufficient numbers because they are by definition "low-risk". A handful of low-risk patients might feel they need to check themselves into a hospital, but very very few of them will actually die of COVID-19, even though there is a strong financial incentive for hospitals to label COVID-19 deaths from those who had COVID-19 when they died, rather than dying of COVID-19.Tylernoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-54907756718118129882020-07-03T06:33:30.551+02:002020-07-03T06:33:30.551+02:00Peter, do you believe that if Cresol was a problem...Peter, do you believe that if Cresol was a problem, and reducing Cresol would help to build dendrites in a 21 year old? How do you know the microbial transplant has the good bacteria that particular person needs? Thanks, Mary<br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-655962722302095847.post-44016195082924048292020-07-02T18:46:34.739+02:002020-07-02T18:46:34.739+02:00Peter, I try to include more fiber, fruit and vege...Peter, I try to include more fiber, fruit and vegetables but it is difficult to follow a strict diet for life. Besides try to avoid soluble fiber that feeds bacterial overgrowth.<br />ValentinaAnonymousnoreply@blogger.com