Thursday, 5 December 2019

Cleveland Clinic Training Video - Psychopharmacology and Autism Spectrum Disorder

Today we look at the progressive end of mainstream medicine’s current take on treating autism, a 45 minute training for doctors treating children with autism, produced by the Cleveland Clinic.

Click on the above link and then on the begin activity box, to start the video.  They even have a quiz at the end.

In the pipeline is a relatively simple post all about dietary autism and a complicated one that tries to apply/simplify genetic models of autism. Sigma-1 receptor agonists will get examined; there is a very interesting Russian one called Afobazole, which I was surprised to see is currently sold on Amazon and eBay.  There are many Sigma-1 receptor agonists (Memantine, Donepezil, Sertraline, Haloperidol, Fluvoxamine etc) but they all have other effects that you likely do not want. Afobazole has a different set of other effects (MT1, MT3, NGF, BNDF, GABAergic etc), but most importantly is reported to be well tolerated and non-addictive.  Afobazole was very recently shown to alleviate cognitive rigidity in an experimental model of ASD.

You might get prescribed Memantine, Donepezil, Sertraline, Haloperidol or Fluvoxamine at the Cleveland Clinic, but there is zero chance of being prescribed Afobazole.

Afobazole also looks potentially interesting for Parkinson's, schizophrenia and anywhere there is ER-stress (Endoplasmic Reticulum stress).  More about ER stress in that future post.


  1. Hello Peter and Community,

    Hope everyone is doing well.

    I just saw an interesting paper I wanted to share and add to our collective knowledge. The paper can be found at:;year=2020;volume=15;issue=6;spage=1140;epage=1149;aulast=Mehan

    The reason I wanted to share it is just in case anyone is dealing with a known mitochondrial issue - maybe this can be helpful.

    It identifies Forskolin as a potential therapeutic, and this is a very easy ingredient to access.

    I hope this is helpful everyone!


    1. AJ, in this paper they made the rats autistic by injecting propionic acid into their spinal fluid. This is an established model of autism.

      This is a reversible model of autism. You can give the rat the antioxidant NAC and the go back to being happy NT rats.

      These researchers injected the rats with Forskolin.

      "Results from this study indicate that FSK exhibits anti-oxidant effects through reductions in ROS and providing its potential against oxidative damage induced by PPA."

      So I think they just showed that the PPA model of autism can be reversed using antioxidants other than NAC.

      NAC can be taken orally or directly into a vein (the latter being much more potent).

      Forskolin has many effects, it even increases thyroid hormone production and IGF-1 levels. So it might make slightly hyperative NT rats.

      "Forskolin is a natural diterpenoid with a wide biological effect. The mechanism of action of forskolin is based on the activation of the adenylyl cyclase enzyme, which results in the synthesis of cAMP. Forskolin increases the level of intracellular cAMP, which is a transmitter of intracellular signals that regulates and affects the activity of many enzymes in the cell [83,84]. This is particularly important in disease entities with reduced levels of this transmitter, such as asthma, cardiovascular disorders and obesity, among others. The Indian nettle C. forskohlii is the natural source of forskolin. Beneficial effects of forskolin have been reported in preclinical and clinical studies on the treatment cystic fibrosis, cardiovascular disease, obesity, allergies, asthma, COPD, diabetes, cancer, thyroid disorders, IOP in glaucoma, and liver fibrosis. Forskolin can interact with the cAMP pathway. More clinical and pre-clinical studies need to be performed to support forskolin efficacy since both the plant extract and forskolin exhibit low toxicity."

  2. looking forward to your take on dietary autism
    Greetings to all

    1. Tanya, the dietary autism post comes out next week, in case anyone gets bored over Christmas. There is actually quite a lot of substance to incorporate.

  3. I tried afobazole, went through a box or two, but didn't really notice anything. I wonder if I would have to take it more long-term to notice benefits. It was definitely authentic though everything else I got from that source was legit. I find the Russian/Latvian medicine Mebicar/Adaptol to be my favorite anxiolytic though, it boasts a super wide dose/safety margin. Doses range from 300mg-10g daily. Just yesterday I finally got a hold of some NACET (NAC Ethyl Ester). Too soon to say for sure but I could swear I feel much better, more 'stable', lucid, alert, calm. Taken orally, it is delivered right inside the cell quite effectively, very little is found in outside the cell in plasma. Has ~60% bioavalability rate vs ~5-10% NAC has.

    Check out this study on NACET (pop it in Sci-Hub if you need full study) -

    1. Dragon, thanks for the comments. NACET is very interesting because it is in-effect a lipophilic (it dissolves in fat not water) pro-drug of NAC. Being lipophilic, it can cross the cell membrane and enter cells, where it converts to NAC.

      Ideally, everyone would be using NACET.

      Mebicar is another interesting drug from the Former Soviet Union, this time from Latvia, like Mildronate. Mebicar is non-addictive and non-sedating.

      It is suggested for anxiety, often accompanied by symptoms of autonomic dysfunction, and for ADHD. The nearest Western drug for these symptoms is Propranolol.


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