Tuesday, 22 March 2016

GABA, bumetanide, ketogenic diet, channelopathies, histamine … and all other things autism

A Guest Post by UK Charity Treating Autism

If you are a reader of this blog and interested in all things autism, especially those things regularly discussed here, you may want to find yourself in London on the weekend of 18-19 June, attending a conference organised by a UK charity Treating Autism. The location is Brunel University campus - a stone’s throw from Heathrow airport, or a fun tube ride from Eurostar St Pancras station.

If you can only attend one day make sure it is Sunday 19th, as this day will feature presentations on most promising treatment approaches in autism including the one on bumetanide for autism titled ‘Reducing symptoms of autism by addressing dysfunctional GABA: A chloride concentration story’ by none other than Dr Lemonnier himself.

Prof Dr Athanasios Evangeliou of Papageorgiou Hospital Thessaloniki will be giving not one but two presentations: ‘Autism, epilepsy and metabolic disorders’ (am) and ‘Alternative” treatments for Autism in mainstream clinical settings’ (pm). He will be discussing many different things, amongst them the merits of screening evaluations and identification of metabolic biomarkers in autism with therapeutic relevance, such as for example biotin, B complex vitamins, branched chain amino acids and ketogenic diet. (To jog your memory a little see here and here.)

John Rodakis of NofOne Research Foundation will be flying over from the States to update us on the latest sulforaphane and suramin autism trials, Dr Coutinho from Oxford Uni will reveal their latest findings on maternal autoantibodies in autism, and there will be a very special presentation by a very special reader and a regular contributor to comment section of this blog – as I am not saying more J you will have to find out by clicking on this link

Hope to see you there!!

(A big Thanks to Peter for allowing me to share this!)


  1. Such good news! And congrats on the presentation!


  2. Good luck AW. BTW, any chance the presentations will be uploaded to YouTube or some similar video sharing site?

    1. Unfortunately that is highly unlikely, too many hoops with that...

      On the plus side the conference has just been approved as a Continuous Professional Development activity (UK medical accreditation, also valid for EU docs) so who knows it might even get some doctors interested enough to actually attend. Might!

  3. Congrarulations to all researchers of the conference, especially to Prof. Dr. Evangeliou for offering autism treatment options and to Agnieszka, a regular reader of Peter's blog, I have the opportunity to follow her interesting comments. Needless to say I would very much like to attend.

  4. Peter this is off topic but I think I remember you covering the TRN (Thalamic Reticular Nucleus) in a previous post as well as potassium channels in another so here is a new paper that came out today that discusses a genetic mutation leading to potassium channel dysfunction in the TRN which can lead to many of the symptoms of autism (at least in mice).

    One thing I think you will be especially interested in is that the mice they bred that lacked a gene necessary for normal TRN function were rescued by a potassium current poster called "1-ethyl-benzimidazolinone" which I am gonna guess is one of those research drugs and not something you would ever give to a human being (I have not looked it up yet).

    On another note, while reading a lot on polyamines recently, I recall that potassium currents can be modulated by polyamines (spermine being the strongest modulator).

  5. Thank you for all kind words. I think we are all learning here so valuable medicine and that I may share some of this at the Conference it is thanks to Peter’s blog.

    Recently I’ve got much support for the idea of autism treatment from the Chair Professor where I work and she even wanted to teach me some gene sequencing techniques in her lab when she heard about calcium channels genetics in ASD. Now the question is how to get such interest also in some more suitable places than tropical medicine institute…


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