Monday, 27 January 2014

Fibromyalgia, Autism and President Putin


I introduced Fibromyalgia in my last post; it is an neurological condition that can cause some very strange symptoms, in addition to pain and fatigue.  I imagine that there are various different underlying causes and so, like autism, it is really a family of disorders with overlapping symptoms.
Surprisingly, at least one type of Fibromyalgia would appear to have similar causes to classic autism, but its onset is after the brain has fully developed.  As with autism, the approved medical treatments are all for the symptoms, rather than the underlying condition.  The underlying condition seems to be a neuro-endocrine inflammatory disorder, sometimes with channelopathies.

One very interesting finding is that exercise consistently helps with the symptoms of Fibromyalgia.  I was reading a paper just last week that showed that exercise (jogging) reduced autistic behaviors.  It has already been well established that exercise is almost as effective as drugs at treating people with depression.

Here are some links:-


So what is the wonderful power behind jogging or swimming, you might be wondering?  Exercise and even passively experiencing a roller-coaster, or motor bike ride, releases certain hormones in your brain, which causes a cascade of changes to many other hormones and neurotransmitters.  Depression, fibromyalgia and indeed autism all include some central hormone dysfunction; shaking up the homeostasis by exercise seems to do good.

I did look, a long time ago, for studies that showed precisely which hormones are affected.  The problem is that hormone levels in the blood do not tell you the hormone levels in the brain; if they did, then there would be a lot of demand for neuro-endocrinologists.    The problem is the blood brain barrier  (BBB).
You can of course measure hormone levels in the spinal fluid, but I do not suppose many people would volunteer for such clinical trials.  As a result, any intervention in brain hormone levels is likely to be a hit and miss affair.  People have tried to do it, but unless you can measure the result scientifically, it will remain voodoo science.
Some expert autism physicians continue to maintain classic autism is not treatable; that would suggest to me, they have never tried.  You can very easily change brain homeostasis, but it might be for better or might be for worse - but you can certainly change it.  Even if you make it worse, you know that you have been able to change it; then it is just a matter of rethinking and trying again.  As a patient, you naturally expect the specialist to get it right with 90+% certainty.  Without being able to measure hormone levels in the brain, it is rather like target shooting, while wearing a blindfold.  Maybe there are some safe interventions that will work in everyone.  I prefer to limit this blog to things I can prove scientifically, so I will keep the rest for my polypill.

For the risk averse amongst you, I suggest you rely on exercise.  Unless you are completely unfit, it seems that exercise can only do good.  You will never know which hormone levels changed, or what neurotransmitter did what, but then you do not need to know.

President Putin
Monty, aged 10 with ASD, has an elder brother Ted, aged 13.  Ted loves history and is also learning Russian; he very much wants to go to visit Moscow and also Putin’s home town of St Petersburg.  Given the choice, he would undoubtedly go to Izhevsk , a city in the western Urals, home of the Kalashnikov factory and museum.

Ted was very impressed to hear Putin telling journalists in Sochi that he swims 1,000 metres every day.  Even the journalists were surprised, “every day?”; “yes, every day”.
So I told Ted, who does have some of the stranger symptoms of fibromyalgia, that I listed in my previous post, if Putin can swim 1,000 metres, then you can swim 500 metres every day.

Today was the first day of the new regime.


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